Editorial Board

Board of Editors Anne Blanche Adams Ilka Becker Cindy Cate A. Craig Eddy Scott Fisk Melissa Hartigan Staff Sean P. Goicoechea Thomas J. Harrington John J. Mudd Lisa M. Roberts Dennis E. Rogers Laura D. Vachowski Nicholas J. Weilhammer Angela Zeilinski Faculty Advisors J. Martin Burke Sally Weave

Quality circles to identify barriers, facilitating factors, and solutions for high-quality primary care for asylum seekers

Straßner C, Gewalt SC, Becker von Rose P, Lorenzen D, Szecsenyi J, Bozorgmehr K. Quality circles to identify barriers, facilitating factors, and solutions for high-quality primary care for asylum seekers. BJGP Open. 2017;1(3):BJGP-2017-0112

Comparison of the INRIM and PTB lattice-spacing standards

To base the kilogram definition on the atomic mass of the silicon 28 atom, the present relative uncertainty of the silicon 28 lattice parameter must lowered to 3E-9. To achieve this goal, a new experimental apparatus capable of a centimetre measurement-baseline has been made at the INRIM. The comparison between the determinations of the lattice parameter of crystals MO*4 of INRIM and WASO4.2a of PTB is intended to verify the measurement capabilities and to assess the limits of this experiment.Comment: 10 pages, 8 figures, submitted to Metrologi

Editorial Board

Editors-in Chief Matthew B. Hayhurst Heather M. Latino Articles Editors Gerry Fagan Lawrence F. Reger Research Editor Ashley S. Burleson Managing Editor Shane P. Coleman Staff Anne Blanche Adams Cynthia Lynn Cate Aimee Grmoljez M. Melissa Hartigan Solomon Neuhardt Ilka Becker A. Craig Eddy Deborah J. Livesay Editing Intern Kathleen A. Brandis Faculty Advisor Carl Tobia

A genome-wide association study of sodium levels and drug metabolism in an epilepsy cohort treated with carbamazepine and oxcarbazepine

open64siObjective: To ascertain the clinical and genetic factors contributing to carbamazepine- and oxcarbazepine-induced hyponatremia (COIH), and to carbamazepine (CBZ) metabolism, in a retrospectively collected, cross-sectional cohort of people with epilepsy. Methods: We collected data on serum sodium levels and antiepileptic drug levels in people with epilepsy attending a tertiary epilepsy center while on treatment with CBZ or OXC. We defined hyponatremia as Na+ ≤134 mEq/L. We estimated the CBZ metabolic ratio defined as the log transformation of the ratio of metabolite CBZ-diol to unchanged drug precursor substrate as measured in serum. Results: Clinical and genetic data relating to carbamazepine and oxcarbazepine trials were collected in 1141 patients. We did not observe any genome-wide significant associations with sodium level in a linear trend or hyponatremia as a dichotomous trait. Age, sex, number of comedications, phenytoin use, phenobarbital use, and sodium valproate use were significant predictors of CBZ metabolic ratio. No genome-wide significant associations with CBZ metabolic ratio were found. Significance: Although we did not detect a genetic predictor of hyponatremia or CBZ metabolism in our cohort, our findings suggest that the determinants of CBZ metabolism are multifactorial.openBerghuis B.; Stapleton C.; Sonsma A.C.M.; Hulst J.; de Haan G.-J.; Lindhout D.; Demurtas R.; Krause R.; Depondt C.; Kunz W.S.; Zara F.; Striano P.; Craig J.; Auce P.; Marson A.G.; Stefansson H.; O'Brien T.J.; Johnson M.R.; Sills G.J.; Wolking S.; Lerche H.; Sisodiya S.M.; Sander J.W.; Cavalleri G.L.; Koeleman B.P.C.; McCormack M.; Avbersek A.; Leu C.; Heggeli K.; Willis J.; Speed D.; Sargsyan N.; Chinthapalli K.; Borghei M.; Coppola A.; Gambardella A.; Becker F.; Rau S.; Hengsbach C.; Weber Y.G.; Delanty N.; Campbell E.; Gudmundsson L.J.; Ingason A.; Stefansson K.; Schneider R.; Balling R.; Francis B.; Jorgensen A.; Morris A.; Langley S.; Srivastava P.; Brodie M.; Todaro M.; Petrovski S.; Hutton J.; Zimprich F.; Krenn M.; Muhle H.; Martin Klein K.; Moller R.; Nikanorova M.; Weckhuysen S.; Rener-Primec Z.Berghuis, B.; Stapleton, C.; Sonsma, A. C. M.; Hulst, J.; de Haan, G. -J.; Lindhout, D.; Demurtas, R.; Krause, R.; Depondt, C.; Kunz, W. S.; Zara, F.; Striano, P.; Craig, J.; Auce, P.; Marson, A. G.; Stefansson, H.; O'Brien, T. J.; Johnson, M. R.; Sills, G. J.; Wolking, S.; Lerche, H.; Sisodiya, S. M.; Sander, J. W.; Cavalleri, G. L.; Koeleman, B. P. C.; Mccormack, M.; Avbersek, A.; Leu, C.; Heggeli, K.; Willis, J.; Speed, D.; Sargsyan, N.; Chinthapalli, K.; Borghei, M.; Coppola, A.; Gambardella, A.; Becker, F.; Rau, S.; Hengsbach, C.; Weber, Y. G.; Delanty, N.; Campbell, E.; Gudmundsson, L. J.; Ingason, A.; Stefansson, K.; Schneider, R.; Balling, R.; Francis, B.; Jorgensen, A.; Morris, A.; Langley, S.; Srivastava, P.; Brodie, M.; Todaro, M.; Petrovski, S.; Hutton, J.; Zimprich, F.; Krenn, M.; Muhle, H.; Martin Klein, K.; Moller, R.; Nikanorova, M.; Weckhuysen, S.; Rener-Primec, Z

Dictionnaire des Naturalismes, C. Becker et P.-J. Dufief

Conçu et dirigé par Colette Becker et par Pierre-Jean Dufief, le Dictionnaire des naturalismes est le fruit d’un long travail d’équipe: il réunit une soixantaine de chercheurs français et étrangers qui ont pu partager réflexions et compétences à l’intérieur d’une plate-forme numérique – gérée par Jean-Sébastien Macke – au fil de la réalisation des volumes. Cet ouvrage «encyclopédique et polyphonique» d’environ mille pages témoigne ainsi d’un projet ambitieux, mais nécessaire: comme il est rap..

Effects Of Stress On Electron Emission From Nanostructured Carbon Materials

The electron field emission from a graphite like amorphous carbon film was investigated. Threshold fields as low as 8 V/νm were observed at an assisting energy of 400eV. The field emission characteristics of the films were explained in terms of the high sp2 concentration, and the high intrinsic compressive stress modifying the electronic band structure of the film/graphitic nanostructures.21417101714McKenzie, D.R., Muller, D., Pailthope, B.A., (1991) Phys. Rev. Lett., 67, p. 773Schwan, J., Ulrich, S., Theel, T., Roth, H., Ehrhardt, H., Becker, P., Silva, S.R.P., (1997) J. Appl. Phys., 82, p. 6024Lifshitz, Y., Kasi, S.R., Rabalais, J.W., Eckstein, W., (1990) Phys. Rev. B, 41, p. 10468Robertson, J., (1993) Diamond Relat. Mater., 2, p. 984Lacerda, R.G., Hammer, P., Lepienski, C.M., Alvarez, F., Marques, F.C., (2001) J. Vac. Sci. Technol. A, 19, p. 971Bhattacharyya, S., Subramanyam, S.V., (1997) Appl. Phys. Lett., 71, p. 632Kilic, C., Mehrez, H., Ciraci, S., (1998) Phys. Rev. B, 58, p. 7872Uher, C., Hockey, R.L., Ben-Jacob, E., (1987) Phys. Rev. B, 35, p. 4483Satyanarayana, B.S., Hart, A., Milne, W.I., Robertson, J., (1997) Appl. Phys. Lett., 71, p. 1430Carey, J.D., Forrest, R.D., Silva, S.R.P., (2001) Appl. Phys. Lett., 78, p. 2339Illie, A., Ferrari, C., Yagi, T., Robertson, J., (2000) Appl. Phys. Lett., 76, p. 2627De Lima M.M., Jr., Lacerda, R.G., Vilcarromero, J., Marques, F.C., (1999) J. Appl. Phys., 86, p. 4936Hoffman, R.W., (1966) Physics of Thin Films, 3, pp. 211-273. , edited by G. Hass and R. E. Thun (Academic, New YorkCarey, J.D., Silva, S.R.P., (2001) Appl. Phys. Lett., 78, p. 347Hammer, P., Victoria, N.M., Alvarez, F., (2000) J. Vac. Sci. Technol. A, 18, p. 2277Lifshitz, Y., Lempert, G.D., Grossman, E., Avigal, L., Uzan-Saguy, C., Kalish, R., Khlik, J., Rabalais, J.W., (1995) Diamond Relat. Mater., 4, p. 318Fallon, P.J., Veerasamy, V.S., Davis, C.A., Robertson, J., Amaratunga, G.A.J., Milne, W.I., Koskinen, J., (1993) Phys. Rev. B, 48, p. 4777Ahuja, R., Auluck, S., Trygg, J., Wills, J.M., Eriksson, O., Johansson, B., (1995) Phys. Rev. B, 51, p. 4813Reynolds, W.N., Goggin, P.R., (1960) Philos. Mag., 5, p. 1049Lynch, R.W., Drickamer, H.G., (1966) J. Chem. Phys., 44, p. 181Chaumet, P.C., Dufour, J.P., (1998) J. Electrost., 43, p. 145Hryd, R., Charlier, A., McRae, E., (1997) Phys. Rev. B, 55, p. 682