366 research outputs found
Labor Market Signaling and Unemployment Duration: Evidence from Germany
The aim of the paper is to examine the consequences of displacement on unemployment duration. Due to ex-ante asymmetric information about the productivity of unemployed applicants, prospective employers use the type of displacement as a costless signal about the ability of the worker when making hiring decisions. While individual layoffs might be caused by workers low productivity, plant closures can be considered as exogenous. Consequently, individual layoffs might attach a negative productivity signal to the worker resulting in longer unemployment duration. To test this hypothesis we use administrative linked employer-employee data for Germany which not only contain daily information on unemployment duration but also allows us to control for the type of displacement. We show that workers displaced due to plant closures and downsizings find indeed significantly faster a new job. We also find the strengths of the signaling value to be proportional to the share of displaced workers
Intracellular Transport and Processing of the Marburg Virus Surface Protein in Vertebrate and Insect Cells
AbstractThe surface protein (GP) of Marburg virus (MBG) is synthesized as a 90-kDa precursor protein which is cotranslationally modified by the addition of high-mannose sugars (140 kDa). This step is followed by the conversion of the N-linked sugars to endoglycosidase H (endo H)-resistant species and the addition of O-linked oligosaccharides leading to a mature protein of 170â200 kDa approximately 30 min after pulse labeling. The mature form of GP is efficiently transported to the plasma membrane. GP synthesized using the T7 polymerase-driven vaccinia virus expression system was transported with essentially the same kinetics as the authentic GP. However, the protein that is shown to appear 30 min after pulse labeling at the plasma membrane was slightly smaller (160 kDa) than GP incorporated into the virions (170 kDa). Using a recombinant baculovirus, GP was expressed at high levels in insect cells. Three different species could be identified: a 90-kDa unglycosylated GP localized in the cytoplasm and two 140-kDa glycosylated proteins. Characterization of the glycosylated GPs revealed that processing of the oligosaccharides of GP was less efficient in insect cells than in mammalian cells. The majority of GP remained endo H sensitive containing high-mannose type N-linked glycans, whereas only a small fraction became endo H resistant carrying processed N-glycans and O-glycans. Tunicamycin treatment of the GP-expressing cells demonstrated that N-glycosylation is essential for the transport of the MBG surface protein
Klimaschutz im Verkehr â Paradigmenwechsel!: Klimaschutz im Verkehr â Paradigmenwechsel!
Anhand der aktuellen und prognostizierten
verkehrlichen Treibhausgasemissionen
wird einleitend die
Bedeutung des Verkehrsbereiches
fĂŒr einen wirksamen Klimaschutz
herausgestellt. AnschlieĂend wird
aus langfristigen TragfÀhigkeitsbetrachtungen
(ca. 1 â 2 t CO2-
Ăq./Person und Jahr) ein maximal
denkbares Nutzungsniveau fossiler
Energie fĂŒr Verkehr abgeleitet,
das deutlich unter den heutigen
VerbrÀuchen liegt. Die Diskussion
der sich daraus ergebenden
Implikationen fĂŒhrt zu folgender
Hauptschlussfolgerung: Es wird
zukĂŒnftig weniger Verkehr geben
(mĂŒssen), dies fĂŒhrt aber nicht zu
weniger MobilitÀt, eher im
Gegenteil. VerÀnderte Raumplanung,
NĂ€he, Nutzenmischung
usw. erlauben es, MobilitĂ€tsbedĂŒrfnisse
sauberer, leiser und
gesĂŒnder zu erfĂŒllen.The paper highlights the importance
of the factor âtrafficâ in any
effective climate protection
regime. Based on long-term
sustainability studies, a maximum
acceptable level of individual
annual CO2 emissions from fossil
fuels is determined. The figure
proposed is far below present-day
levels. Implications are discussed
and the following main conclusion
is derived: Future societies will
have to make do with considerably
less traffic: However, this will
not necessarily lead to less mobility.
On the contrary, different patterns
of land use, multi-functional
urban structures, new pricing
regimes, altered travel patterns
and technical improvements will
actually permit greater mobility
(e.g. among groups socially
excluded today) with less traffic
Stickoxide, Partikel und Kohlendioxid: Grenzwerte, Konflikte und Handlungsmöglichkeiten kommunaler Luftreinhaltung im Verkehrsbereich: Informationen und Empfehlungen fĂŒr Mitarbeiter deutscher Kommunen
Die ab dem 1.1.2010 geltenden erweiterten LuftqualitĂ€tsgrenzwerte stellen die Kom-munen vor allem in verkehrlich belasteten Gebieten vor Probleme. Zum einen haben die Kommunen sicherzustellen, dass die Immissionsgrenzwerte eingehalten werden, zum anderen stehen ihnen aber nur eine Reihe beschrĂ€nkt wirkungsvoller MaĂnahmen zur VerfĂŒgung. Wie können die (GroĂ-) StĂ€dte darauf reagieren?
ZunĂ€chst kann festgehalten werden, dass der Verkehrsbereich zukĂŒnftig den Schwerpunkt von MaĂnahmen zu Klimaschutz und Luftreinhaltung bilden muss. Die wesentlichen urbanen Problemfelder werden durch den Verkehr bestimmt; bei den relevanten Luftschadstoffen stellen Fahrzeuge mit Dieselmotoren die Hauptemittenten dar und zur Reduktion der CO2-Emissionen mĂŒssen alle Fahrzeuge deutlich mehr beitragen als bisher.
In der Vergangenheit war die Reduktion von Verkehrsemissionen vorrangig als Frage der Weiterentwicklung der Fahrzeugtechnik interpretiert worden. Da die technischen Weiterentwicklungen allein fĂŒr die Problemlösung nicht ausreichen, sind grundsĂ€tzliche Ănderungen von Verkehrsverhalten und Verkehrssystemen unumgĂ€nglich. Eine Verbesserung der Raumordnung, weniger Zersiedelung, eine multifunktionale Stadt der kurzen Wege und ein anderes MobilitĂ€tsverhalten der Bevölkerung weisen die höchsten Reduktionspotentiale auf, wirken aber vor allem langfristig.
Eine Ăbersicht mit denkbaren MaĂnahmengruppen zur Erreichung der LuftqualitĂ€ts-
und Klimaschutzziele wurde erarbeitet, die zur Entwicklung spezifischer Pakete von Kommunen genutzt werden kann
Rainfall estimates on a gridded network (REGEN) â a global land-based gridded dataset of daily precipitation from 1950 to 2016
We present a new global land-based daily precipitation dataset from 1950 using an interpolated network of in situ data called Rainfall Estimates on a Gridded Network â REGEN. We merged multiple archives of in situ data including two of the largest archives, the Global Historical Climatology Network â Daily (GHCN-Daily) hosted by National Centres of Environmental Information (NCEI), USA, and one hosted by the Global Precipitation Climatology Centre (GPCC) operated by Deutscher Wetterdienst (DWD). This resulted in an unprecedented station density compared to existing datasets. The station time series were quality-controlled using strict criteria and flagged values were removed. Remaining values were interpolated to create area-average estimates of daily precipitation for global land areas on a 1ââĂâ1â latitudeâlongitude resolution. Besides the daily precipitation amounts, fields of standard deviation, kriging error and number of stations are also provided. We also provide a quality mask based on these uncertainty measures. For those interested in a dataset with lower station network variability we also provide a related dataset based on a network of long-term stations which interpolates stations with a record length of at least 40 years. The REGEN datasets are expected to contribute to the advancement of hydrological science and practice by facilitating studies aiming to understand changes and variability in several aspects of daily precipitation distributions, extremes and measures of hydrological intensity. Here we document the development of the dataset and guidelines for best practices for users with regards to the two datasets.This research has been supported by the Australian Research Council (grant nos. DP160103439, CE110001028 and DE150100456) and the Spanish Ministry for Science and Innovation (grant no. RYC-2017-22964)Peer ReviewedPostprint (published version
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