The Luminosity Function of Young Star Clusters In "The Antennae" Galaxies (NGC 4038/4039)

The WFPC2 of the HST has been used to obtain high-resolution images of NGC 4038/4039 that go roughly 3 magnitudes deeper in V than previous observations made during Cycle 2 (-14 < M_V < -6). To first order the luminosity function (LF) is a power law, with exponent \alpha = -2.12 +/- 0.04. However, after decoupling the cluster and stellar LFs, which overlap in the range -9 < M_V < -6, we find an apparent bend in the young cluster LF at approximately M_V = -10.4. The LF has a power law exponent -2.6 +/- 0.2 in the brightward and -1.7 +/- 0.2 in the faintward. The bend corresponds to a mass ~ 10^5 M_{\odot}, only slightly lower than the characteristic mass of globular clusters in the Milky Way (~2x10^5 M_{\odot}). The star clusters of the Antennae appear slightly resolved, with median effective radii of 4 +/- 1 pc, similar to or perhaps slightly larger than those of globular clusters in our Galaxy. However, the radial extents of some of the very young clusters (ages < 10 Myr) are much larger than those of old globular clusters. A combination of the UBVI colors, \Halpha morphology, and GHRS spectra enables us to age-date the clusters in different regions of The Antennae. We find two groups of young star clusters with ages <~ 20Myr and ~100Myr, as well as an intermediate-age group (~500 Myr) and a handful of old globular clusters from the progenitor galaxies. Age estimates derived from GHRS spectroscopy yield 3 +/- 1 Myr for Knot K (just south of the nucleus of NGC 4038) and 7 +/- 1 Myr for Knot S in the Western Loop, in good agreement with ages derived from the UBVI colors. Effective gas-outflow velocities from Knots S and K are estimated to be about 25-30 km/s. However, the measured widths of the interstellar absorption lines suggest dispersion velocities of ~400 km/s along the lines of sight to Knots S and K.Comment: 56 pages, 4 tables and 23 figures, texts in AAS style, to be published in A

Fluxes in M-theory on 7-manifolds and G structures

We consider warp compactifications of M-theory on 7-manifolds in the presence of 4-form fluxes and investigate the constraints imposed by supersymmetry. As long as the 7-manifold supports only one Killing spinor we infer from the Killing spinor equations that non-trivial 4-form fluxes will necessarily curve the external 4-dimensional space. On the other hand, if the 7-manifold has at least two Killing spinors, there is a non-trivial Killing vector yielding a reduction of the 7-manifold to a 6-manifold and we confirm that 4-form fluxes can be incorporated if one includes non-trivial SU(3) structures.Comment: 13 pages, Latex; minor changes & add reference

Two phase I studies of BI 836880, a vascular endothelial growth factor/angiopoietin-2 inhibitor, administered once every 3 weeks or once weekly in patients with advanced solid tumors

BACKGROUND: BI 836880 is a humanized bispecific nanobody® that inhibits vascular endothelial growth factor and angiopoietin-2. Here, we report results from two phase I, nonrandomized, dose-escalation studies (NCT02674152 and NCT02689505; funded by Boehringer Ingelheim) evaluating BI 836880 in patients with confirmed locally advanced or metastatic solid tumors, refractory to standard therapy, or for which standard therapy was ineffective. PATIENTS AND METHODS: Patients aged ≥18 years, with an Eastern Cooperative Oncology Group performance status of 0-2 and adequate organ function received escalating intravenous doses of BI 836880 once every 3 weeks (Q3W; Study 1336.1) or once weekly (QW; Study 1336.6). Primary objectives were maximum tolerated dose (MTD) and recommended phase II dose of BI 836880, based on dose-limiting toxicities (DLTs) during the first cycle. RESULTS: Patients received one of five dosages of 40-1000 mg Q3W (29 patients) or 40-240 mg QW (24 patients). One DLT occurred with Q3W treatment [Grade (G) 3 pulmonary embolism (1000 mg)]. Five DLTs occurred in four patients treated QW [G2 proteinuria (120 mg); G3 hypertension (180 mg); G3 proteinuria and G3 hypertension (240 mg); and G4 respiratory distress (240 mg)]. All patients experienced adverse events, most commonly hypertension with Q3W treatment (89.7%; G3 41.4%), and asthenia with QW treatment (62.5%). Two patients treated Q3W (both 1000 mg) and three patients treated QW (120 mg, 2 patients; 180 mg, 1 patient) experienced partial response. CONCLUSIONS: The MTD of BI 836880 was 720 mg Q3W and 180 mg QW. BI 836880 was generally manageable and demonstrated preliminary efficacy. CLINICAL TRIAL REGISTRATION: ClinicalTrials.govNCT02674152; https://clinicaltrials.gov/ct2/show/NCT02674152 and NCT02689505; https://clinicaltrials.gov/ct2/show/NCT0268950

Combined transcriptomic-(1)H NMR metabonomic study reveals yhat monoethylhexyl phthalate stimulates adipogenesis and glyceroneogenesis in human adipocytes

Adipose tissue is a major storage site for lipophilic environmental contaminants. The environmental metabolic disruptor hypothesis postulates that some pollutants can promote obesity or metabolic disorders by activating nuclear receptors involved in the control of energetic homeostasis. In this context, monoethylhexyl phthalate (MEHP) is of particular concern since it was shown to activate the peroxisome proliferator-activated receptor γ (PPARγ) in 3T3-L1 murine preadipocytes. In the present work, we used an untargeted, combined transcriptomic-(1)H NMR-based metabonomic approach to describe the overall effect of MEHP on primary cultures of human subcutaneous adipocytes differentiated in vitro. MEHP stimulated rapidly and selectively the expression of genes involved in glyceroneogenesis, enhanced the expression of the cytosolic phosphoenolpyruvate carboxykinase, and reduced fatty acid release. These results demonstrate that MEHP increased glyceroneogenesis and fatty acid reesterification in human adipocytes. A longer treatment with MEHP induced the expression of genes involved in triglycerides uptake, synthesis, and storage; decreased intracellular lactate, glutamine, and other amino acids; increased aspartate and NAD, and resulted in a global increase in triglycerides. Altogether, these results indicate that MEHP promoted the differentiation of human preadipocytes to adipocytes. These mechanisms might contribute to the suspected obesogenic effect of MEHP

Background geometry of DLCQ M theory on a p-torus and holography

Via supergravity, we argue that the infinite Lorentz boost along the M theory circle a la Seiberg toward the DLCQ M theory compactified on a p-torus (p<5) implies the holographic description of the microscopic theory. This argument lets us identify the background geometries of DLCQ $M$ theory on a p-torus; for p=0 (p=1), the background geometry turns out to be eleven-dimensional (ten-dimensional) flat Minkowski space-time, respectively. Holography for these cases results from the localization of the light-cone momentum. For p = 2,3,4, the background geometries are the tensor products of an Anti de Sitter space and a sphere, which, according to the AdS/CFT correspondence, have the holographic conformal field theory description. These holographic descriptions are compatible to the microscopic theory of Seiberg based on $\tilde{M}$ theory on a spatial circle with the rescaled Planck length, giving an understanding of the validity of the AdS/CFT correspondence.Comment: 16 pages, Revtex, no figure

IMB-3: a large water Cherenkov detector for nucleon decay and neutrino interactions

The IMB experiment, a large water Cherenkov detector which began data collection in September 1982, has undergone several upgrades to improve light collection, on-line processing power, data throughput and buffering, calibration, and operating efficiency. The current device, known as IMB-3, enjoys a factor of four light collection advantage over its precursor. Since May 1986, it has been used to search for such diverse phenomena as nucleon decay, dark matter, neutrino oscillation, and magnetic monopoles, and to study stellar collapse and cosmic rays. Due to its large size and long exposure time IMB presents unique challenges. The design and operation of the IMB-3 detector are described in detail.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/31079/1/0000756.pd

Fermi Large Area Telescope Observations of Gamma-ray Pulsars PSR J1057-5226, J1709-4429, and J1952+3252

The Fermi Large Area Telescope (LAT) data have confirmed the pulsed emission from all six high-confidence gamma-ray pulsars previously known from the EGRET observations. We report results obtained from the analysis of 13 months of LAT data for three of these pulsars (PSR J1057-5226, PSR J1709-4429, and PSR J1952+3252) each of which had some unique feature among the EGRET pulsars. The excellent sensitivity of LAT allows more detailed analysis of the evolution of the pulse profile with energy and also of the variation of the spectral shape with phase. We measure the cutoff energy of the pulsed emission from these pulsars for the first time and provide a more complete picture of the emission mechanism. The results confirm some, but not all, of the features seen in the EGRET data.Comment: Accepted for publication in ApJ. 45 pages, 12 figures, 11 tables. Corresponding authors: O. Celik, F. Gargano, T. Reposeur, D.J. Thompso

Virulence Evolution of the Human Pathogen Neisseria meningitidis by Recombination in the Core and Accessory Genome

Joseph B, Schwarz RF, Linke B, et al. Virulence Evolution of the Human Pathogen Neisseria meningitidis by Recombination in the Core and Accessory Genome. PLoS ONE. 2011;6(4): e18441.Background: Neisseria meningitidis is a naturally transformable, facultative pathogen colonizing the human nasopharynx. Here, we analyze on a genome-wide level the impact of recombination on gene-complement diversity and virulence evolution in N. meningitidis. We combined comparative genome hybridization using microarrays (mCGH) and multilocus sequence typing (MLST) of 29 meningococcal isolates with computational comparison of a subset of seven meningococcal genome sequences. Principal Findings: We found that lateral gene transfer of minimal mobile elements as well as prophages are major forces shaping meningococcal population structure. Extensive gene content comparison revealed novel associations of virulence with genetic elements besides the recently discovered meningococcal disease associated (MDA) island. In particular, we identified an association of virulence with a recently described canonical genomic island termed IHT-E and a differential distribution of genes encoding RTX toxin-and two-partner secretion systems among hyperinvasive and non-hyperinvasive lineages. By computationally screening also the core genome for signs of recombination, we provided evidence that about 40% of the meningococcal core genes are affected by recombination primarily within metabolic genes as well as genes involved in DNA replication and repair. By comparison with the results of previous mCGH studies, our data indicated that genetic structuring as revealed by mCGH is stable over time and highly similar for isolates from different geographic origins. Conclusions: Recombination comprising lateral transfer of entire genes as well as homologous intragenic recombination has a profound impact on meningococcal population structure and genome composition. Our data support the hypothesis that meningococcal virulence is polygenic in nature and that differences in metabolism might contribute to virulence

Search for CP Violation in the Decay Z -> b (b bar) g

About three million hadronic decays of the Z collected by ALEPH in the years 1991-1994 are used to search for anomalous CP violation beyond the Standard Model in the decay Z -> b \bar{b} g. The study is performed by analyzing angular correlations between the two quarks and the gluon in three-jet events and by measuring the differential two-jet rate. No signal of CP violation is found. For the combinations of anomalous CP violating couplings, ${\hat{h}}_b = {\hat{h}}_{Ab}g_{Vb}-{\hat{h}}_{Vb}g_{Ab}$ and $h^{\ast}_b = \sqrt{\hat{h}_{Vb}^{2}+\hat{h}_{Ab}^{2}}$, limits of \hat{h}_b < 0.59$and$h^{\ast}_{b} < 3.02$ are given at 95\% CL.Comment: 8 pages, 1 postscript figure, uses here.sty, epsfig.st