Cognitive-behaviour therapy for post-traumatic stress in schizophrenia: a randomised controlled trial

Background. There is limited evidence for effective interventions in the treatment of posttraumatic stress symptoms within individuals diagnosed with schizophrenia. Clinicians have concerns about using exposure treatments with this patient group. The current trial was designed to evaluate a 16-session cognitive restructuring programme, without direct exposure, for the treatment of posttraumatic stress symptoms specifically within individuals diagnosed with schizophrenia. Method. A multicentre randomized controlled single-blinded trial with assessments at 0 months, 6-months (post-treatment) and 12 months (follow-up) was conducted. Sixty-one participants diagnosed with schizophrenia and exhibiting posttraumatic stress symptoms were recruited. Those randomized to treatment were offered up to 16 sessions of cognitive behaviour therapy (CBT, including psychoeducation, breathing training and cognitive restructuring) over a 6-month period, with the control group offered routine clinical services. The main outcome was blind rating of posttraumatic stress symptoms using the Clinician Administered PTSD Scale for Schizophrenia (CAPS-S). Secondary outcomes were psychotic symptoms as measured by the Positive and Negative Symptom Scale (PANSS) and the Psychotic Symptom Rating Scale (PSYRATS). Results. Both the treatment and control groups experienced a significant decrease in posttraumatic stress symptoms over time but there was no effect of the addition of CBT on either the primary or secondary outcomes. Conclusions. The current trial did not demonstrate any effect in favour of CBT. Cognitive restructuring programmes may require further adaptation to promote emotional processing of traumatic memories within people diagnosed with a psychotic disorder

Political institutions and debt crises

This paper shows that political institutions matter in explaining defaults on external and domestic debt obligations. We explore a large number of political and macroeconomic variables using a non-parametric technique to predict safety from default. The advantage of this technique is that it is able to identify patterns in the data that are not captured in standard probit analysis. We find that political factors matter, and do so in different ways for democratic and non-democratic regimes, and for domestic and external debt. In democracies, a parliamentary system or sufficient checks and balances almost guarantee the absence of default on external debt when economic fundamentals or liquidity are sufficiently strong. In dictatorships, high stability and tenure play a similar role for default on domestic debt

Obesity Accelerates Acute Promyelocytic Leukemia in Mice and Reduces Sex Differences in Latency and Penetrance

Objective: Obesity has emerged as a prominent risk factor for multiple serious disease states, including a variety of cancers, and is increasingly recognized as a primary contributor to preventable cancer risk. However, few studies of leukemia have been conducted in animal models of obesity. This study sought to characterize the impact of obesity, diet, and sex in a murine model of acute promyelocytic leukemia (APL). Methods: Male and female C57BL/6J.mCG+/PR mice, genetically predisposed to sporadic APL development, and C57BL/6J (wild type) mice were placed on either a high-fat diet (HFD) or a low-fat diet (LFD) for up to 500 days. Results: Relative to LFD-fed mice, HFD-fed animals displayed increased disease penetrance and shortened disease latency as indicated by accelerated disease onset. In addition, a diet-responsive sex difference in APL penetrance and incidence was identified, with LFD-fed male animals displaying increased penetrance and shortened latency relative to female counterparts. In contrast, both HFD-fed male and female mice displayed 100% disease penetrance and insignificant differences in disease latency, indicating that the sexual dimorphism was reduced through HFD feeding. Conclusions: Obesity and obesogenic diet promote the development of APL in vivo, reducing sexual dimorphisms in disease latency and penetrance

Multicentric Castleman's disease: a case report

Castleman's disease is a clinicopathological entity associated with lymphoproliferation. We report a case of a 71 year old gentleman who was initially clinically suspected to have lymphoma (owing to clinical features at presentation), but was later histologically confirmed to have Castleman's disease. This case report underlines the importance of definitive histological diagnosis in patients with lympadenopathic presentation associated with systemic symptoms and the distinctiveness of multicentric Castleman's disease from malignant lymphoma. In this report we also attempt to provide new insight (through the review of medical literature) into the clinical features, pathogenesis, diagnosis and treatment of this rare and relatively benign disorder

Thermal expansion in small metal clusters and its impact on the electric polarizability

The thermal expansion coefficients of $\mathrm{Na}_{N}$ clusters with $8 \le N \le 40$ and $\mathrm{Al}_{7}$, $\mathrm{Al}_{13}^-$ and $\mathrm{Al}_{14}^-$ are obtained from {\it ab initio} Born-Oppenheimer LDA molecular dynamics. Thermal expansion of small metal clusters is considerably larger than that in the bulk and size-dependent. We demonstrate that the average static electric dipole polarizability of Na clusters depends linearly on the mean interatomic distance and only to a minor extent on the detailed ionic configuration when the overall shape of the electron density is enforced by electronic shell effects. The polarizability is thus a sensitive indicator for thermal expansion. We show that taking this effect into account brings theoretical and experimental polarizabilities into quantitative agreement.Comment: 4 pages, 2 figures, one table. Accepted for publication in Physical Review Letters. References 10 and 23 update

An orbital-free molecular dynamics study of melting in K_20, K_55, K_92, K_142, Rb_55 and Cs_55 clusters

The melting-like transition in potasium clusters K_N, with N=20, 55, 92 and 142, is studied by using an orbital-free density-functional constant-energy molecular dynamics simulation method, and compared to previous theoretical results on the melting-like transition in sodium clusters of the same sizes. Melting in potasium and sodium clusters proceeds in a similar way: a surface melting stage develops upon heating before the homogeneous melting temperature is reached. Premelting effects are nevertheless more important and more easily established in potasium clusters, and the transition regions spread over temperature intervals which are wider than in the case of sodium. For all the sizes considered, the percentage melting temperature reduction when passing from Na to K clusters is substantially larger than in the bulk. Once those two materials have been compared for a number of different cluster sizes, we study the melting-like transition in Rb_55 and Cs_55 clusters and make a comparison with the melting behavior of Na_55 and K_55. As the atomic number increases, the height of the specific heat peaks decreases, their width increases, and the melting temperature decreases as in bulk melting, but in a more pronounced way.Comment: LaTeX file. 6 pages with 17 pictures. Final version with minor change

Art work or money: Conflicts in the construction of a creative identity

The identity projects of novice creative practitioners must take account of the economy of art work. It has been suggested (McRobbie, 2002a) that in the contemporary cultural industries in the UK, a new understanding of the connection between creative work and money has replaced past 'anti-commercial' notions. This claim is investigated through a narrative-discursive analysis of interviews from a longitudinal study with current and recent Art and Design postgraduates. Their ongoing identity projects are shaped by established understandings of creative work and the prospects it offers for earning and employment, and also by more local discursive resources given by personal life contexts. An analysis of two interviews with a single speaker shows how these resources are taken up within her ongoing and distinctive identity project. Both old and new repertoires of art and money are in play in her talk. She must negotiate dilemmas and potentially troubled positionings in order to reconcile a creative identity with relationships and responsibilities towards others. Coherence is only achieved momentarily and is disrupted by new life circumstances. By investigating an identity project at the level of talk, the analysis shows the complexity of the speaker's work to construct and claim a creative identity

Hegemony through responsibilisation : getting working-class students into higher education in the United Kingdom

This article examines the role of the New Labour governments’ agenda for widening participation in higher education as a form of responsibilising discourse of working-class young people. Under the New Labour administrations of 1997—2010, a concerted attempt was made to attract working-class students into higher education through promotional initiatives such as the Aimhigher programme. Drawing from Raymond Williams’ discussion of hegemony and also from Nikolas Rose’s concept of the ‘enterprising self’, this article examines three explanatory/promotional documents from the Aimhigher programme aimed at working-class young people and their parents. The documents are analysed as materialisations of a powerfully hegemonic discourse of ‘responsibilisation’ towards participation in higher education. The article concludes with a discussion of the ways in which the widening access agenda has shifted since the coalition government came to power in 2010

Neutron polarizabilities investigated by quasi-free Compton scattering from the deuteron

Measuring Compton scattered photons and recoil neutrons in coincidence, quasi-free Compton scattering by the neutron has been investigated at MAMI (Mainz) at $theta^{lab}_\gamma=136^o$ in an energy range from 200 to 400 MeV. From the data a polarizability difference of $\alpha_n - \beta_n = 9.8 \pm 3.6(stat)^{+2.1}_{-1.1}(syst)\pm 2.2(model)$ in units of $10^{-4}fm^3$ has been determined. In combination with the polarizability sum $\alpha_n+\beta_n= 15.2\pm 0.5$ deduced from photo absorption data, the neutron electric and magnetic polarizabilities, $\alpha_n=12.5\pm 1.8(stat)^{+1.1}_{-0.6}(syst)\pm 1.1(model)$ and $\beta_n = 2.7\mp 1.8(stat)^{+0.6}_{-1.1}(syst)\mp 1.1(model)$, are obtained