Adenoma Characteristics at First Colonoscopy as Predictors of Adenoma Recurrence and Characteristics at Follow-Up

All patients with colorectal adenomas may not require identical follow-up. We aimed to determine if adenoma characteristics at initial colonoscopy could predict adenoma recurrence or characteristics at follow-up. The number of adenomas and the size, type, and degree of atypia in 479 patients in a polyp prevention trial were evaluated as predictors of the same characteristics at follow-up using odds ratios (ORs) with 95% confidence intervals (CIs). Multiple logistic regression analysis was performed to determine if several baseline characteristics were simultaneously associated with outcome

Bayesian earthquake dating and seismic hazard assessment using chlorine-36 measurements (BED v1)

Over the past twenty years, analyzing the abundance of the isotope chlorine-36 (36Cl) has emerged as a popular tool for geologic dating. In particular, it has been observed that 36Cl measurements along a fault plane can be used to study the timings of past ground displacements during earthquakes, which in turn can be used to improve existing seismic hazard assessment. This approach requires accurate simulations of 36Cl accumulation for a set of fault-scarp rock samples, which are 5 progressively exhumed during earthquakes, in order to infer displacement histories from 36Cl measurements. While the physical models underlying such simulations have continuously been improved, the inverse problem of recovering displacement histories from 36Cl measurements is still mostly solved on an ad-hoc basis. The current work resolves this situation by providing a MATLAB implementation of a fast, automatic, and flexible Bayesian Markov-chain Monte Carlo algorithm for the inverse problem, and provides a validation of the 36Cl approach to inference of earthquakes from the demise of the Last Glacial 10 Maximum until present. To demonstrate its performance, we apply our algorithm to a synthetic case to verify identifiability, and to the Fiamignano and Frattura faults in the Italian Apennines in order to infer their earthquake displacement histories and to provide seismic hazard assessments. The results suggest high variability in slip rates for both faults, and large displacements on the Fiamignano fault at times when the Colosseum and other ancient buildings in Rome were damaged

Course-based Science Research Promotes Learning in Diverse Students at Diverse Institutions

Course-based research experiences (CREs) are powerful strategies for spreading learning and improving persistence for all students, both science majors and nonscience majors. Here we address the crucial components of CREs (context, discovery, ownership, iteration, communication, presentation) found across a broad range of such courses at a variety of academic institutions. We also address how the design of a CRE should vary according to the background of student participants; no single CRE format is perfect. We provide a framework for implementing CREs across multiple institutional types and several disciplines throughout the typical four years of undergraduate work, designed to a variety of student backgrounds. Our experiences implementing CREs also provide guidance on overcoming barriers to their implementation

Hemodialyzer mass transfer-area coefficients for urea increase at high dialysate flow rates

Hemodialyzer mass transfer-area coefficients for urea increase at high dialysate flow rates. The dialyzer mass transfer-area coefficient (KoA) for urea is an important determinant of urea removal during hemodialysis and is considered to be constant for a given dialyzer. We determined urea clearance for 22 different models of commercial hollow fiber dialyzers (N = ~5/model, total N = 107) in vitro at 37°C for three countercurrent blood (Qb) and dialysate (Qd) flow rate combinations. A standard bicarbonate dialysis solution was used in both the blood and dialysate flow pathways, and clearances were calculated from urea concentrations in the input and output flows on both the blood and dialysate sides. Urea KoA values, calculated from the mean of the blood and dialysate side clearances, varied between 520 and 1230ml/min depending on the dialyzer model, but the effect of blood and dialysate flow rate on urea KoA was similar for each. Urea KoA did not change (690 ± 160 vs. 680 ± 140 ml/min, P = NS) when Qb increased from 306 ± 7 to 459 ± 10ml/min at a nominal Qd of 500ml/min. When Qd increased from 504 ± 6 to 819 ± 8ml/min at a nominal Qb of 450ml/min, however, urea KoA increased (P < 0.001) by 14 ± 7% (range 3 to 33%, depending on the dialyzer model) to 780 ± 150ml/min. These data demonstrate that increasing nominal Qd from 500 to 800ml/min alters the mass transfer characteristics of hollow fiber hemodialyzers and results in a larger increase in urea clearance than predicted assuming a constant KoA

CSO Bolocam 1.1 mm continuum mapping of the Braid Nebula star formation region in Cygnus OB7

We present a 1.1 mm map of the Braid Nebula star formation region in Cygnus OB7 taken using Bolocam on the Caltech Submillimeter Observatory. Within the 1 deg2 covered by the map, we have detected 55 cold dust clumps all of which are new detections. A number of these clumps are coincident with IRAS point sources although the majority are not. Some of the previously studied optical/near-IR sources are detected at 1.1 mm. We estimate total dust/gas masses for the 55 clumps together with peak visual extinctions. We conclude that over the whole region, approximately 20% of the clumps are associated with IRAS sources suggesting that these are protostellar objects. The remaining 80% are classed as starless clumps. In addition, both FU Orionis (FUor) like objects in the field, the Braid Star and HH 381 IRS, are associated with strong millimeter emission. This implies that FUor eruptions can occur at very early stages of pre-main-sequence life. Finally, we determine that the cumulative clump mass function for the region is very similar to that found in both the Perseus and Ï? Ophiuchus star-forming regions. © 2011. The American Astronomical Society. All rights reserved

Nucleon Charge Symmetry Breaking and Parity Violating Electron-Proton Scattering

The consequences of the charge symmetry breaking effects of the mass difference between the up and down quarks and electromagnetic effects for searches for strangeness form factors in parity violating electron scattering from the proton are investigated. The formalism necessary to identify and compute the relevant observables is developed by separating the Hamiltonian into charge symmetry conserving and breaking terms. Using a set of SU(6) non-relativistic quark models, the effects of the charge symmetry breaking Hamiltonian are considered for experimentally relevant alues of the momentum transfer and found to be less than about 1 percent. The charge symmetry breaking corrections to the Bjorken sum rule are also studied and shown to vanish in first-order perturbation theory.Comment: 35 pages, 9 figure