Advantages and disadvantages of hormone replacement therapy

In the developed countries, more than 30% of female population is in the postmenopusal period of their life. Approximately one third of these present with severe clinical menopausal symptoms, such as hot flushes, sleeplessness, night sweats, and depression. Many women search medical help. By means of hormone replacement therapy (HRT), these problems can be either completely eliminated or alleviated in 90% of women. The suspected association between HRT and risk of carcinoma should be ignored, however. While estrogens in combination with progestogens exert a protective effec against ovarian and endometrial carcinomas, a possible correlation between HRT and breast cancer has not been fully explained yet. Nevertheless, some published reports have indicated a slightly increased risk of breast cancer after a prolonged use of HRT

Surgical treatment of endometrial carcinoma unresolved issues

V razvitem svetu je med ginekološkimi raki najpogostejši endometrijski karcinom. Zdravljenje izbora je kirurgija, ki jo pri obsežnejši bolezni dopolnjuje radioterapija in vedno pogosteje tudi kemoterapija. Obsežnost kirurškega posega je še vedno nedorečena, kar zahteva novejše doktrine. Pojavljajo se novi pristopi v zdravljenju, upoštevati pa moramo tudi specifičnost zdravljenja pri mlajših bolnicah.Endometrial carcinoma is the most common type of gynaecological cancer in the developed world. The selected treatment is surgery, complemented by radiotherapy in the event of a more advanced disease, and increasingly also by chemotherapy. The scope of a surgical treatment is still to be determined, which requires adoption of new doctrines. New approaches to treatment are being developed, but it is necessary to consider also the specificity of the treatment of younger patients

New ESMO/ESTRO/ESP guidelines in endometrial cancer

Smernice zdravljenja zgodnjega raka endometrija narekujejo kirurški pristop z adjuvantnim zdravljenjem. Dodatno zdravljenje je odvisno od kliničnih in pato-histoloških dejavnikov. Na osnovi teh bolnice uvrstimo v skupino z nizkim tveganjem, z nizkim srednjim tveganjem in skupino z visokim tveganjem. Molekularna klasifikacija omogoča natančnejšo opredelitev lastnosti karcinoma in napove tveganje za ponovitev bolezni