Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

The Politics of ‘Transnational Organized Crime’: Discourse, Reflexivity and the Narration of ‘Threat’

Over the past decade the perceived 'threat' of transnational organised crime (TOC) to the security of western political economies has become a principal issue on the agendas of key international forums such as the United Nations, G7/8 elite industrial countries and the Council of Europe. The intense policy activity around this threat is indicative of a key trend in post-Cold War international relations, that is, the reorientation of western security, intelligence and defence agencies toward crime control. Risk assessments and research evidence provided by international relations departments in higher education institutions, especially in the USA, have been particularly influential in providing the rationale for this reorientation. It is argued here, however, that there is a danger of intellectuals being drawn into the legitimisation of policies the terms of which are defined for them rather than by them. This jeopardises the critical contribution which academic research can make to policy change and learning, in particular it precludes a more reflexive approach to 'evidence-based' government. The paper draws upon discourse analysis and the study of 'governmentality' to develop a more reflexive interrogation of the assumptions underpinning this policy-shift in post-Cold War international relations. This is exemplified through an analysis of the two principal competing discourses on the threat of TOC and these are distinguished in terms of their focus on 'criminologies of the other' and 'criminologies of the self'. The former narrates threats to security in terms of external, nationally and ethnically defined, pressures. The later perceive threats more in terms of the internal challenges now facing 'sovereign' governments struggling to command highly diverse, dynamic and complex social-political problems like organised crime. The ways in which these competing discourses constrain and enable alternative policy responses to TOC are examined

'Endemic to the species':Ordering the 'other' via organised crime

The United States has been the prime mover in the establishment of both the concept of organised crime and the use of the concept in its attempt to establish global hegemony, in which law enforcement became a little more than a front for a government-backed central casting agency, stereotyping both heroes and villains. This article offers an account of how the ?Other? has been used as prism for the construction of organised crime primarily in the United States and how this construction, as a franchise, has been exported on the international level and on heterogeneous criminal landscapes