Volatiles in glasses from the HSDP2 drill core

H2O, CO2, S, Cl, and F concentrations are reported for 556 glasses from the submarine section of the 1999 phase of HSDP drilling in Hilo, Hawaii, providing a high-resolution record of magmatic volatiles over ~200 kyr of a Hawaiian volcano's lifetime. Glasses range from undegassed to having lost significant volatiles at near-atmospheric pressure. Nearly all hyaloclastite glasses are degassed, compatible with formation from subaerial lavas that fragmented on entering the ocean and were transported by gravity flows down the volcano flank. Most pillows are undegassed, indicating submarine eruption. The shallowest pillows and most massive lavas are degassed, suggesting formation by subaerial flows that penetrated the shoreline and flowed some distance under water. Some pillow rim glasses have H2O and S contents indicating degassing but elevated CO2 contents that correlate with depth in the core; these tend to be more fractionated and could have formed by mixing of degassed, fractionated magmas with undegassed magmas during magma chamber overturn or by resorption of rising CO2-rich bubbles by degassed magmas. Intrusive glasses are undegassed and have CO2 contents similar to adjacent pillows, indicating intrusion shallow in the volcanic edifice. Cl correlates weakly with H2O and S, suggesting loss during low-pressure degassing, although most samples appear contaminated by seawater-derived components. F behaves as an involatile incompatible element. Fractionation trends were modeled using MELTS. Degassed glasses require fractionation at pH2O ≈ 5–10 bars. Undegassed low-SiO2 glasses require fractionation at pH2O ≈ 50 bars. Undegassed and partially degassed high-SiO2 glasses can be modeled by coupled crystallization and degassing. Eruption depths of undegassed pillows can be calculated from their volatile contents assuming vapor saturation. The amount of subsidence can be determined from the difference between this depth and the sample's depth in the core. Assuming subsidence at 2.5 mm/y, the amount of subsidence suggests ages of ~500 ka for samples from the lower 750 m of the core, consistent with radiometric ages. H2O contents of undegassed low-SiO2 HSDP2 glasses are systematically higher than those of high-SiO2 glasses, and their H2O/K2O and H2O/Ce ratios are higher than typical tholeiitic pillow rim glasses from Hawaiian volcanoes

Critical current density and ac harmonic voltage generation in YBa2Cu3O7−δYBa_2Cu_3O_{7-\delta} thin films by the screening technique

The temperature and field dependence of harmonics in voltage $V_n=V'_n-iV"_n$ using the screening technique have been measured for $\mathrm{Y}\mathrm{Ba}_{2}\mathrm{Cu}_3\mathrm{O}_{7-\delta}$ superconducting thin films. Using the Sun model we obtained the curves for the temperature-dependent critical current density $J_c(T)$. In addition, we applied the criterion proposed by Acosta et al. to compute $J_c(T)$. Also, we made used of the empirical law $J_c \propto (1-T/T_c)^n$ as an input in our calculations to reproduce experimental harmonic generation up to the fifth harmonic. We found that most models fit well the fundamental voltage but higher harmonics are poorly reproduced. Such behavior suggests the idea that higher harmonics contain information concerning complex processes like flux creep or thermally assisted flux flow.Comment: 2 pages, 2 figure

Knowledge graph prediction of unknown adverse drug reactions and validation in electronic health records

Unknown adverse reactions to drugs available on the market present a significant health risk and limit accurate judgement of the cost/benefit trade-off for medications. Machine learning has the potential to predict unknown adverse reactions from current knowledge. We constructed a knowledge graph containing four types of node: drugs, protein targets, indications and adverse reactions. Using this graph, we developed a machine learning algorithm based on a simple enrichment test and first demonstrated this method performs extremely well at classifying known causes of adverse reactions (AUC 0.92). A cross validation scheme in which 10% of drug-adverse reaction edges were systematically deleted per fold showed that the method correctly predicts 68% of the deleted edges on average. Next, a subset of adverse reactions that could be reliably detected in anonymised electronic health records from South London and Maudsley NHS Foundation Trust were used to validate predictions from the model that are not currently known in public databases. High-confidence predictions were validated in electronic records significantly more frequently than random models, and outperformed standard methods (logistic regression, decision trees and support vector machines). This approach has the potential to improve patient safety by predicting adverse reactions that were not observed during randomised trials

The Adiabatic Instability on Cosmology's Dark Side

We consider theories with a nontrivial coupling between the matter and dark energy sectors. We describe a small scale instability that can occur in such models when the coupling is strong compared to gravity, generalizing and correcting earlier treatments. The instability is characterized by a negative sound speed squared of an effective coupled dark matter/dark energy fluid. Our results are general, and applicable to a wide class of coupled models and provide a powerful, redshift-dependent tool, complementary to other constraints, with which to rule many of them out. A detailed analysis and applications to a range of models are presented in a longer companion paper.Comment: 4 pages, 1 figur

Megahertz serial crystallography

The new European X-ray Free-Electron Laser is the first X-ray free-electron laser capable of delivering X-ray pulses with a megahertz inter-pulse spacing, more than four orders of magnitude higher than previously possible. However, to date, it has been unclear whether it would indeed be possible to measure high-quality diffraction data at megahertz pulse repetition rates. Here, we show that high-quality structures can indeed be obtained using currently available operating conditions at the European XFEL. We present two complete data sets, one from the well-known model system lysozyme and the other from a so far unknown complex of a β-lactamase from K. pneumoniae involved in antibiotic resistance. This result opens up megahertz serial femtosecond crystallography (SFX) as a tool for reliable structure determination, substrate screening and the efficient measurement of the evolution and dynamics of molecular structures using megahertz repetition rate pulses available at this new class of X-ray laser source

Search for radial velocity variations in eight M-dwarfs with NIRSPEC/Keck II

Context. Radial velocity (RV) measurements from near-infrared spectra have become a potentially powerful tool to search for planets around cool stars and sub-stellar objects. As part of a large survey to characterize M-dwarfs using NIRSPEC at Keck II, we obtained spectra of eight late M-dwarfs (spectral types M5.0-M8.0) during two or more observing epochs per target. These spectra were taken with intermediate spectral resolving powers (R \sim 20,000) in the J-band. Aims. We search for relative radial velocity variability in these late M-dwarfs and test the NIRSPEC capability of detecting short period brown dwarf and massive planetary companions around low-mass stars in the J-band (\approx 1.25 micron). Additionally, we reanalyzed the data of the M8-type star vB10 (one of our targets) presented in Zapatero Osorio et al. (2009), which were obtained with the same instrumentation as our data. Methods. [...] Results. For the entire M-dwarf sample, we do not find any evidence of relative RV variations induced by a short period brown dwarf or massive planetary companion. The typical RV precision of the measurements is between 180 and 300 m/s, which is sufficient to detect hot Neptunes around M-dwarfs. Also, we find that the spurious RV shift in Zapatero et al. (2009) of the star VB10 was caused by asymmetries in the instrumental profile between different observing epochs, which were not taken into account in their analysis.Comment: A&A, 7 pages, 5 figure

Magnetization Relaxation via Quantum and Classical Vortex Motion in a Bose Glass Superconductor

I show that in Bose Glass superconductor with high $j_c$ and at low $T$ the magnetization relaxation (S), dominated by quantum tunneling, is $\propto{\sqrt j_c}$, which crosses over to the conventional classical rate $\propto T/j_c$ at higher $T$ and lower $j_c$, with the crossover $T^*\sim j_c^{3/2}$. I argue that due to interactions between flux lines there exist three relaxation regimes, depending on whether $BB_\phi$, corresponding to Strongly-pinned Bose Glass (SBG) with large $j_{c2}$, Mott Insulator (MI) with vanishing S, and Weakly-pinned Bose Glass (WBG) characterized by small $j_{c1}$. I discuss the effects of interactions on $j_c$ and focus attention on the recent experiment which is consistently described by the theory.Comment: 4 pages, self-unpacking uuencoded compressed postscript file with figures already inside text; to appear in Phys. Rev. Lett.(1995

CleanBGP: Verifying the consistency of BGP data

Copyright © 2008 IEEEBGP data contains artifacts introduced by the measurement infrastructure which can substantially affect analysis. This is especially important in operational systems where "crying wolf" will result in an operator ignoring alarms. In this paper, we investigate the causes of measurement artifacts in BGP data - cross-checking and using properties of the data to infer the presence of an artifact and minimize its impact. We have developed a prototype tool, CleanBGP, which detects and corrects the effects of artifacts in BGP data, which we believe should be used prior to the analysis of such data. CleanBGP provides the user with an understanding of the artifacts present, a mechanism to remove their effects, and consequently the limitations of results can be fully quantified.Ashley Flavel, Olaf Maennely, Belinda Chiera, Matthew Roughan and Nigel Bea

Collective Transport in Arrays of Quantum Dots

(WORDS: QUANTUM DOTS, COLLECTIVE TRANSPORT, PHYSICAL EXAMPLE OF KPZ) Collective charge transport is studied in one- and two-dimensional arrays of small normal-metal dots separated by tunnel barriers. At temperatures well below the charging energy of a dot, disorder leads to a threshold for conduction which grows linearly with the size of the array. For short-ranged interactions, one of the correlation length exponents near threshold is found from a novel argument based on interface growth. The dynamical exponent for the current above threshold is also predicted analytically, and the requirements for its experimental observation are described.Comment: 12 pages, 3 postscript files included, REVTEX v2, (also available by anonymous FTP from external.nj.nec.com, in directory /pub/alan/dotarrays [as separate files]) [replacement: FIX OF WRONG VERSION, BAD SHAR] March 17, 1993, NEC

Ground-based optical transmission spectrum of the hot Jupiter HAT-P-1b

Time-series spectrophotometric studies of exoplanets during transit using ground-based facilities are a promising approach to characterize their atmospheric compositions. We aim to investigate the transit spectrum of the hot Jupiter HAT-P-1b. We compare our results to those obtained at similar wavelengths by previous space-based observations. We observed two transits of HAT-P-1b with the Gemini Multi-Object Spectrograph (GMOS) instrument on the Gemini North telescope using two instrument modes covering the 320 - 800 nm and 520 - 950 nm wavelength ranges. We used time-series spectrophotometry to construct transit light curves in individual wavelength bins and measure the transit depths in each bin. We accounted for systematic effects. We addressed potential photometric variability due to magnetic spots in the planet's host star with long-term photometric monitoring. We find that the resulting transit spectrum is consistent with previous Hubble Space Telescope (HST) observations. We compare our observations to transit spectroscopy models that marginally favor a clear atmosphere. However, the observations are also consistent with a flat spectrum, indicating high-altitude clouds. We do not detect the Na resonance absorption line (589 nm), and our observations do not have sufficient precision to study the resonance line of K at 770 nm. We show that even a single Gemini/GMOS transit can provide constraining power on the properties of the atmosphere of HAT-P-1b to a level comparable to that of HST transit studies in the optical when the observing conditions and target and reference star combination are suitable. Our 520 - 950 nm observations reach a precision comparable to that of HST transit spectra in a similar wavelength range of the same hot Jupiter, HAT-P-1b. However, our GMOS transit between 320 - 800 nm suffers from strong systematic effects and yields larger uncertainties.Comment: A&A, accepted, 16 pages, 8 figures, 5 table