27 research outputs found
Spectral estimates for resolvent differences of self-adjoint elliptic operators
The concept of quasi boundary triples and Weyl functions from extension theory of symmetric operators in Hilbert spaces is developed further and spectral estimates for resolvent differences of two self-adjoint extensions in terms of general operator ideals are proved. The abstract results are applied to self-adjoint realizations of second order elliptic differential operators on bounded and exterior domains, and partial differential operators with δ-potentials supported on hypersurfaces are studied
Teachers’ affective presentation of children’s books and young children’s display of affective engagement during classroom book reading
Highlights of the Sixteenth Annual Summer Meeting of the American Orthopaedic Foot and Ankle Society, Vail, Colorado, July 13–15, 2000
Image-guided Cryotherapy for Musculoskeletal Tumors
Background: This article represents a review about the use of image-guided cryotherapy in the treatment of musculoskeletal tumor lesions. Cryotherapy is able to induce a lethal effect on cancer cells through direct and indirect mechanisms. In this manuscript, we combined our experience with that of other authors who have published on this topic in order to provide indications on when to use cryotherapy in musculoskeletal oncology.
Discussion: Image-Guided percutaneous cryotherapy is a therapeutic method now widely accepted in the treatment of patients with musculoskeletal tumors. It can be used both for palliative treatments of metastatic bone lesions and for the curative treatment of benign bone tumors such as osteoid osteoma or osteoblastoma. In the treatment of bone metastases, cryotherapy plays a major role in alleviating or resolving disease-related pain but it has also been demonstrated that it can have a role in local disease control. In recent years, the use of cryotherapy have also expanded for the treatment of both benign and malignant soft tissue tumors.
Conclusion: Percutaneous cryotherapy can be considered a safe and effective technique in the treatment of benign and malignant musculoskeletal tumors. Cryotherapy can be considered the first option in benign tumor lesions such as osteoid osteoma and a valid alternative to radiofrequency ablation. In the treatment of painful bone metastases, it must be considered secondarily to other standard treatments (radiotherapy, bisphosphonate therapy and chemotherapy) where they are no longer effective in controlling the disease or when they cannot be repeated (for example radiotherapy)