2 research outputs found
A multi-scale approach to the physics of ion beam cancer therapy
We propose a multi-scale approach to understanding physics related to the
ion/proton-beam cancer therapy and calculation of the probability of the DNA
damage as a result of irradiation of patients with energetic (up to 430 MeV/u)
ions. This approach is inclusive with respect to different scales starting from
the long scale defined by the ion stopping followed by a smaller scale defined
by secondary electrons and radicals ending with the shortest scale defined by
interactions of secondaries with the DNA. We present calculations of the
probabilities of single and double strand breaks of the DNA and suggest a way
of further elaboration of such calculations.Comment: submitted to RADAM2008 proceedings. 8 pages,5 Figures, class files
for AIP include
Ion-beam therapy: from electron production in tissue like media to DNA damage estimations
Radiation damage induced by ion beams is traditionally treated at different
levels of theoretical approaches, for the different scales and mechanisms
involved.We present here details of a combined approach that, from a method at
a nanoscopic scale, attempts to merge with higher scales existing results, by
tuning the analytical method employed when extended to larger scale and so
yielding a consistent picture of the entire process. Results will show the
possibility to get a good agreement with macroscale methods and, on the other
hand, to produce a reliable electron energy spectra to be used for DNA damage
estimations.Comment: 7 pages,5 figures, class files for AIP include