Bartın İli örneğinde yeşil alanların ulaşılabilirliğinin değerlendirilmesi üzerine bir araştırma

Tasarım çözümleri iyi ve kolay ulaşılabilen parklar kentsel yaşam kalitesinin önemli bir parçasıdır. Ulaşılabilirliği kolay olan parklar kent insanının fiziksel aktivitesinin artmasına katkı sağlamaktadır. Bu çalışmada Bartın ili parkları alansal büyüklük, ulaşılabilirlik ve eğim yönünden incelenmiştir. Çalışmada Coğrafi Bilgi Sistemleri (CBS)’den yararlanılmıştır. Çalışmada Bartın ilindeki toplam 93 adet park değerlendirilmiştir. Araştırma kapsamında ele alınan parklar alansal büyüklükleri bakımından sınıflandırıldığında, ilde, semt parkı (1 adet), mahalle parkı (2 adet) ve çocuk bahçesi (1 adet) olarak tanımlanabilecek 3 farklı park büyüklüğü olduğu belirlenmiştir. Alansal büyüklük açısından tanımsız olan 89 adet park ise standart altı parklar olarak değerlendirilmiştir. Ulaşılabilirlik sınırı içerisindeki eğim grupları beş sınıfta (%0-4, %4-5, %5-8, %8-12 ve %1

Statistical Analysis of the Impact of Employees' Demographic Characteristics on Organizational Climate Perception: The Case of Süreyya Paşa Chest Diseases Hospital

İşletme olarak hastaneler, her türlü sağlık hizmetinin üretildiği, karmaşık yapılı ve yüksek düzeyde uzmanlaşmayı gerektiren sağlık kurumlarıdır. Hastaneler hem emek hem de sermaye yoğun işletme özelliğine sahip sağlık kurumlardır. Sağlık sektöründe giderek artan bir rekabet ortamı oluşmaktadır. Böyle bir ortamda rakiplerden önde olabilmek için örgütsel iklim ve örgütsel bağlılık kadar bu iki kavramı etkileyen faktörler de son derece önemlidir. Bir örgütte çalışanların örgüt amaçlarını benimsemeleri, değer yargılarını kabul etmeleri, inanç ve kurallara uygun davranışlarda bulunmaları ve kendilerinden beklenen davranışları göstermelerinin anahtarı olarak “örgütsel iklim”; işletmelerin rekabet avantajı sağlayabilmeleri ve vasıflı iş görenleri bünyelerinde tutabilmeleri için ise “örgütsel bağlılık” vazgeçilmez olarak görülebilir. Bu çalışma sağlık çalışanlarının algıladıkları hizmetkâr liderlik anlayışı çerçevesinde örgütsel iklim ve örgütsel bağlılık arasında anlamlı bir ilişkinin var olup olmadığını belirlemek amacıyla yapılmıştır. Çalışma 30.10.2017 ile 30.12.2017 tarihleri arasında İstanbul İli Kamu Hastaneler Birliğine bağlı bir devlet hastanesinde aktif olarak çalışan 495 sağlık personelinden 254’üne uygulanmıştır. Örneklem, rastgele örneklem seçim tekniği olup katılım %52,93’dür. Çalışmada veri toplama aracı olarak; Robert Stringer tarafından geliştirilmiş, örgüt iklimi ölçeği; Meyer ve Allen tarafından geliştirilmiş örgütsel bağlılık ölçeği ve çalışanların sosyal-demografik niteliklerinden oluşan bir anket formu kullanılmıştır. Ölçek ve alt boyut puanları normal dağılım gösterdiğinden cinsiyet, medeni durum; yaş, öğrenim düzeyi, kadro durumu, kıdem, kamuda çalışma süresi, toplam aylık gelir değişkenlerine göre karşılaştırılmıştır. Gruplar arasındaki anlamlı farklılık için de ikili karşılaştırmalar yapılmıştır. Örgütsel iklim ölçeği ve alt boyut puanlarının hem cinsiyete hem de medeni duruma göre, aynı zamanda yaş gruplarına, öğrenim düzeyine, mesleki kıdemine, kamuda çalışma süresine göre anlamlı farklılık göstermediği belirlenmiştir.As an enterprise, hospitals are health institutions where all kinds of health services are produced, complex structured and requiring high_x000D_ level of specialization. Hospitals are both health-intensive and capital-intensive health institutions. There is an increasing competitive_x000D_ environment in the health sector. In this competitive environment, the factors affecting these two concepts are as important as the_x000D_ organizational climate and organizational commitment to be ahead of the competitors. "Organizational climate" is the key for people working in an organization to adopt organizational goals, accept value judgments, engage in relationships that conform to beliefs and_x000D_ norms, and demonstrate expected behavior. “Organizational commitment” can be seen as indispensable for enterprises to gain_x000D_ competitive advantage and to retain qualified employees. This study was conducted to determine whether there is a meaningful_x000D_ relationship between the perceived servant leadership understanding of healthcare personnel and organizational climate and_x000D_ organizational commitment. The study was applied to 254 out of 495 health personnel who were actively working in a public hospital_x000D_ affiliated with the Public Hospitals Association of Istanbul between 30.10.2017 and 30.12.2017. The sample was randomly selected and_x000D_ the participation rate was 52,93%. In the study, servant leadership scale was used as a data collection tool; Organizational climate scale_x000D_ developed by Robert Stringer; Organizational commitment scale developed by Meyer and Allen and a questionnaire consisting of_x000D_ organizational commitment scale and social-demographic characteristics of employees. As the scale and subscale scores showed normal_x000D_ distribution, gender, marital status; age, education level, staff status, seniority, working time in public sector, total monthly income were_x000D_ compared. Pairwise comparisons were also made for the significant difference between the groups. It was found that the organizational_x000D_ climate scale and sub-dimension scores did not differ significantly according to both gender and marital status, age groups, education_x000D_ level, professional seniority, and duration of work in the public sector.As an enterprise, hospitals are health institutions where all kinds of health services are produced, complex structured and requiring high level of specialization. Hospitals are both health-intensive and capital-intensive health institutions. There is an increasing competitive environment in the health sector. In this competitive environment, the factors affecting these two concepts are as important as the organizational climate and organizational commitment to be ahead of the competitors

Evaluation of financial performance of paper companies traded at BIST with TOPSIS method

Aim of study: It was aimed to rank financial performance of companies in the paper industry traded at BIST. Material and methods: The financial performances of seven companies in the paper industry which are traded on the Borsa Istanbul (BIST) were determined by using financial data in 2016. For this purpose, ten financial ratios were obtained from the financial data of companies, each of which had its own superiority. The data were conducted by the TOPSIS (Technique for Order Preference by Similarity to Ideal Solution) method which is the "Multi Criteria Decision Making" (MCDM) method to interpret. Main results: The results indicated that the companies were ranked follows; ALKA, KARTN, VKING, BAKAB, TIRE, OLMIP and KAPLM based on the financial performance scores. Research highlights: In Turkey, production in paper industry meets nearly half of the consumption and paper demand are met by imports. The high prices of energy and initial investment costs encourage imports of paper products and they prevent new investments. From this perspective, growth, development and high performance of paper companies will keep this industry alive.Çalışmanın amacı: BİST’de işlem gören kağıt sektöründeki firmaların finansal performanslarına göre sıralanması amaçlanmıştır. Materyal ve yöntem: Borsa İstanbul’da (BIST) işlem gören kağıt sektöründeki 7 firmanın 2016 yılına ait verileri kullanılarak finansal performansları belirlenmeye çalışılmıştır. Bu amaçla, şirketlere ait finansal verilerden 10 finansal oran elde edilmiştir ve bu finansal oranların her biri diğerlerine göre üstünlüğe sahiptir. Bütünleşik bir değerlendirme yapılması amacıyla, veriler “Çok Kriterli Karar Verme” (ÇKKV) yöntemlerinden olan TOPSIS (Technique for Order Preference by Similarity to Ideal Solution) yöntemi ile değerlendirilmiştir. Sonuçlar: Şirketler finansal performanslarına göre ALKA, KARTN, VKING, BAKAB, TIRE, OLMIP ve KAPLM olarak sıralanmıştır.. Araştırma vurguları: Ülkemiz kağıt sektöründe gerçekleştirilen üretim ile tüketimin yarısı karşılanabilmekte ve kağıt ihtiyacı ithalatla karşılanmaktadır. Enerji fiyatlarının ve ilk yatırım maliyetlerinin yüksek olması yeni yatırımları engellerken ithalata teşvik etmektedir. Bu bakımdan sektörde var olan firmaların gelişmesi, büyümesi ve performanslarının yüksek olması sektörü canlı tutacaktı

Türkiye’de orman bölge müdürlüklerinin endüstriyel odun üretim miktarı istatistiklerinin benzerliklerinin kümeleme ve diskriminant analizi ile araştırılması

Aim of study: In this study, the amount of industrial wood production of the regional directorates of forestry in Turkey was examined deeply and the similarities between the regional directorates in industrial wood production were investigated by cluster and discriminant analysis. Area of study: The study area is regional directorates of forestry in Turkey. Material and Method: Seven different variables were used to construct similar clusters. The arithmetic mean of these seven variables was taken for 4 years (2013-2016). Cluster and discriminant analysis were used as method. Main results: According to the clustering analysis results, it was determined that regional directorates of forestry could be divided into maximum 6 and minimum 2 groups. As a result of the discriminant analysis conducted to determine the highest success of the groupings, it was determined that the regional directorates of forestry distinguished in 100% success in 6 groups. Also, it was found that a Kastamonu regional directorate of forestry, which has the highest value in industrial wood production, has formed a group alone. Highlights: For the production of industrial wood, the regional directorates of forestry can put more emphasis on the use of forest areas. Thus, we can avoid the dependence on foreign sources.Çalışmanın amacı: Bu çalışmada orman bölge müdürlüklerinin endüstriyel odun üretim miktarları detaylı bir şekilde incelenmiş olup, endüstriyel odun üretimi bakımından bölge müdürlüklerinin benzerlikleri küme ve diskriminant analiz yardımıyla araştırılmıştır. Çalışma alanı: Türkiye’deki orman bölge müdürlükleri çalışma alanını oluşturmaktadır. Materyal ve Yöntem: Benzer özellikleri taşıyan kümeleri oluşturmak için yedi farklı değişken kullanılmıştır. Bu değişkenlerin 2013-2016 yıllarındaki değerlerinin ortalaması alınmıştır. Araştırma yöntemi olarak ise kümeleme analizi ve diskriminant analizi kullanılmıştır. Sonuçlar: Kümeleme analizi sonucuna göre, orman bölge müdürlüklerini en fazla 6 ve en az 2 gruba ayrılabileceği tespit edilmiştir. Oluşturulan gruplamalardan en yüksek başarıyı belirlemek için yürütülen ayırma analizi sonucunda orman bölge müdürlüklerinin 6’li gruplamada %100 başarı elde ettiği saptanmıştır. Ayrıca, endüstriyel odun üretiminde en yüksek değere sahip olan Kastamonu orman bölge müdürlüğünün tek başına bir grup oluşturduğu bulunmuştur. Önemli Vurgular: Endüstriyel odun üretimi için orman bölge müdürlükleri orman alanlarının kullanımı ile ilgili çalışmalara daha fazla önem vererek dışa bağımlılığın önüne geçebiliriz

Analyses with the Video Head Impulse Test During the Canalith Repositioning Maneuver in Patients with Isolated Posterior Semicircular Canal Benign Paroxysmal Positional Vertigo

Objective: To evaluate the posterior semicircular canal (PSCC) functions using video head impulse test (vHIT) during canalith repositioning maneuver (CRM) treatment in patients with isolated, posterior semicircular canal benign paroxysmal positional vertigo (PSCC-BPPV).Methods: A total of 44 subjects comprising of 24 subjects with isolated PSCC-BPPV and 20 age- and sex-matched healthy control subjects were enrolled in the present study. vHIT was performed for the affected PSCC before and just after CRM and at the third and seventh day and first month to evaluate vestibulo-ocular reflex (VOR) gain, gain asymmetry (GA), and corrective saccades. Repeated determinations of VOR gain and GA were compared to evaluate the time course of vHIT measurements during CRM treatment in isolated PSCC-BPPV patients, and the values were also compared with the control group.Results: VOR gains and GA values were not statistically different before and after CRM and at the thirdday, seventh-day and first-month visits for the affected PSCC. Moreover, values did not differ between the BPPV and control groups, and none of the subjects demonstrated corrective saccades.Conclusion: To our knowledge, this study is the first report to investigate vHIT measurements with a time course of alterations during CRM treatment in PSCC-BPPV patients. vHIT may not provide an additional contribution for evaluating vestibular dysfunction during the diagnosis and treatment of isolated PSCC-BPPV

Childhood Nasal Foreign Bodies: Analysis of 1724 Cases

Objective:This study evaluates the characteristics of the foreign bodies removed from the nose, the treatment methods used, and the complications associated with the foreign body, and discusses the reports in the literature.Methods:Age, gender, type of foreign body, side of nose, clinical symptoms, complaints, diagnosis and treatment methods were retrospectively evaluated in all 1724 pediatric patients with foreign bodies.Results:Of the 1724 patients, 841 (48.7%) were female and 883 (51.3%) were male. Their mean age was 4.3±3.06 years (age range: 4 months-16 years). Foreign body was found on the right side in 928 (53.8%), on the left-side in 768 (44.5%) and bilaterally in 28 (1.6%) patients. The foreign bodies were inorganic substances such as beads, paper, napkins, toy parts, batteries, pencils, erasers in 1287 cases (74.7%) and organic materials such as hazelnuts, walnuts and fruit seeds in 437 cases (25.3%). The foreign bodies were extracted in outpatient settings in 1709 cases. Fifteen patients in whom the foreign body was located in the posterior region and/or who were uncooperative were treated under anesthesia. The most common complication was epistaxis. Septal perforation was seen in one patient with alkaline battery.Conclusion:In pediatric patients presented to the otolaryngology and the pediatrics clinics with complaints involving nasal obstruction, unilateral purulent nasal discharge, epistaxis, and foul odor, possibility of a foreign body in the nose should be kept in mind

Retrospective Analysis of Surgically Managed Maxillofacial Fractures in Kayseri Training and Research Hospital

Objective: To retrospectively evaluate the clinical and surgical data of patients with maxillofacial fracture (MFF) who were surgically treated at the Department of ENT and Head Neck Surgery in the Kayseri Training and Research Hospital and to compare and discuss the results with relevant literature, including that from Turkey.Methods: Data concerning the age, gender, etiology, type and site of injury, treatment modality, and postoperative complications were collected and analyzed from medical records of patients who underwent maxillofacial surgery for MFF at the Department of ENT and Head Neck Surgery in the Kayseri Training and Research Hospital between January 2013 and March 2015.Results: A total of 35 patients were surgically treated because of MFF between January 2013 and March 2015. Of the 35 patients, 28 (80%) were male, whereas seven (20%) were female. Traffic accidents (40%) were the most frequent cause of MFFs. Mandibular fractures (49.1%) were the most common fractures, followed by zygomatic fractures (31.6%). Surgical management of MFFs was performed via closed reduction (17.5%) and/ or open reduction with internal fixation by miniplates (82.5%). A total of five complications were observed in the present study: malunion (n=2), removal of fixation plate because of infection (n=2), and permanent infraorbital nerve injury (n=1).Conclusion: Based on the experience from the close proximity of the area, we think that surgeries for MFFs should be in the surgical repertoire of ENT surgeons

Discovery of therapeutic agents targeting PKLR for NAFLD using drug repositioning

Background: Non-alcoholic fatty liver disease (NAFLD) encompasses a wide spectrum of liver pathologies. However, no medical treatment has been approved for the treatment of NAFLD. In our previous study, we found that PKLR could be a potential target for treatment of NALFD. Here, we investigated the effect of PKLR in in vivo model and performed drug repositioning to identify a drug candidate for treatment of NAFLD. Methods: Tissue samples from liver, muscle, white adipose and heart were obtained from control and PKLR knockout mice fed with chow and high sucrose diets. Lipidomics as well as transcriptomics analyses were conducted using these tissue samples. In addition, a computational drug repositioning analysis was performed and drug candidates were identified. The drug candidates were both tested in in vitro and in vivo models to evaluate their toxicity and efficacy. Findings: The Pklr KO reversed the increased hepatic triglyceride level in mice fed with high sucrose diet and partly recovered the transcriptomic changes in the liver as well as in other three tissues. Both liver and white adipose tissues exhibited dysregulated circadian transcriptomic profiles, and these dysregulations were reversed by hepatic knockout of Pklr. In addition, 10 small molecule drug candidates were identified as potential inhibitor of PKLR using our drug repositioning pipeline, and two of them significantly inhibited both the PKLR expression and triglyceride level in in vitro model. Finally, the two selected small molecule drugs were evaluated in in vivo rat models and we found that these drugs attenuate the hepatic steatosis without side effect on other tissues. Interpretation: In conclusion, our study provided biological insights about the critical role of PKLR in NAFLD progression and proposed a treatment strategy for NAFLD patients, which has been validated in preclinical studies. Funding: ScandiEdge Therapeutics and Knut and Alice Wallenberg Foundation

Combined metabolic activators improve metabolic functions in the animal models of neurodegenerative diseases

Background: Neurodegenerative diseases (NDDs), including Alzheimer's disease (AD) and Parkinson's disease (PD), are associated with metabolic abnormalities. Integrative analysis of human clinical data and animal studies have contributed to a better understanding of the molecular and cellular pathways involved in the progression of NDDs. Previously, we have reported that the combined metabolic activators (CMA), which include the precursors of nicotinamide adenine dinucleotide and glutathione can be utilized to alleviate metabolic disorders by activating mitochondrial metabolism. Methods: We first analysed the brain transcriptomics data from AD patients and controls using a brain-specific genome-scale metabolic model (GEM). Then, we investigated the effect of CMA administration in animal models of AD and PD. We evaluated pathological and immunohistochemical findings of brain and liver tissues. Moreover, PD rats were tested for locomotor activity and apomorphine-induced rotation. Findings: Analysis of transcriptomics data with GEM revealed that mitochondrial dysfunction is involved in the underlying molecular pathways of AD. In animal models of AD and PD, we showed significant damage in the high-fat diet groups' brain and liver tissues compared to the chow diet. The histological analyses revealed that hyperemia, degeneration and necrosis in neurons were improved by CMA administration in both AD and PD animal models. These findings were supported by immunohistochemical evidence of decreased immunoreactivity in neurons. In parallel to the improvement in the brain, we also observed dramatic metabolic improvement in the liver tissue. CMA administration also showed a beneficial effect on behavioural functions in PD rats. Interpretation: Overall, we showed that CMA administration significantly improved behavioural scores in parallel with the neurohistological outcomes in the AD and PD animal models and is a promising treatment for improving the metabolic parameters and brain functions in NDDs.PoLiMeR Innovative Training Network ; SNIC ; ScandiBio Therapeutics ; ScandiBio Therapeutics and Knut ; Knut och Alice Wallenbergs Stiftels