Right-Angle Shaped Elements as Dual-Band Metamaterial Absorber in Terahertz

AbstractMetamaterial absorbers display potential applications in the field of photonics and have been investigated extensively during the last decade. We propose a dual-band resonant metamaterial absorber with right-angle shaped elements (RAEs) in the terahertz range based on numerical simulations. The absorber remains insensitive to a wide range of incidence angles (0°–70°) by showing a minimum absorbance of ~80% at 70°. Furthermore, the proposed absorber is highly independent on any state of polarization of the incidence electromagnetic wave due to the high absorbance, i.e., greater than 80%, recorded for the considered polarization states. To further comprehend the slight variations in absorbance as a function of change in the angle of incidence, the impedance of the structure has been critically examined. The metamaterial absorber is simple in design, and we provide a possible path of fabrication.</jats:p

Investigating the influence of a powder compact's geometry on its pore structure and optical properties using terahertz spectroscopy

In this study, terahertz time domain spectroscopy (THz-TDS) is used to analyze how the geometry of a compact affects its pore structure (pore shape and orientation). By using flat-faced and biconvex compacts, it was evident from our analysis that pores tend to assume specific shapes and orientations based on the compact's geometry and this was found to significantly affect the extracted optical properties of samples prepared by mixing a material with polyethylene (PE) as diluent and subsequent compaction. However, such sensitivity to the pore properties opens a number of industrial applications such as for quality testing of pharmaceutical tablets. A comparison made between the PE based compacts and a set of pharmaceutical tablets prepared from the same formulation has revealed that flatfaced and biconvex compacts possess different pore geometries and hence different optical properties

Characterization of the Pore Structure of Functionalized Calcium Carbonate Tablets by Terahertz Time-Domain Spectroscopy and X-Ray Computed Microtomography

Novel excipients are entering the market to enhance the bioavailability of drug particles by having a high porosity and, thus, providing a rapid liquid uptake and disintegration to accelerate subsequent drug dissolution. One example of such a novel excipient is functionalized calcium carbonate, which enables the manufacture of compacts with a bimodal pore size distribution consisting of larger interparticle and fine intraparticle pores. Five sets of functionalized calcium carbonate tablets with a target porosity of 45%-65% were prepared in 5% steps and characterized using terahertz time-domain spectroscopy and X-ray computed microtomography. Terahertz time-domain spectroscopy was used to derive the porosity using effective medium approximations, that is, the traditional and an anisotropic Bruggeman model. The anisotropic Bruggeman model yields the better correlation with the nominal porosity (R$^{2}$ = 0.995) and it provided additional information about the shape and orientation of the pores within the powder compact. The spheroidal (ellipsoids of revolution) shaped pores have a preferred orientation perpendicular to the compaction direction causing an anisotropic behavior of the dielectric porous medium. The results from X-ray computed microtomography confirmed the nonspherical shape and the orientation of the pores, and it further revealed that the anisotropic behavior is mainly caused by the interparticle pores. The information from both techniques provides a detailed insight into the pore structure of pharmaceutical tablets. This is of great interest to study the impact of tablet microstructure on the disintegration and dissolution performance.Drs Markl and Zeitler would like to acknowledge the U.K. Engineering and Physical Sciences Research Council for funding (EP/L019922/1)

Optics-based compressibility parameter for pharmaceutical tablets obtained with the aid of the terahertz refractive index

The objective of this study is to propose a novel optical compressibility parameter for porous pharmaceutical tablets. This parameter is defined with the aid of the effective refractive index of a tablet that is obtained from non-destructive and contactless terahertz (THz) time-delay transmission measurement. The optical compressibility parameter of two training sets of pharmaceutical tablets with $\textit{a priori}$ known porosity and mass fraction of a drug was investigated. Both pharmaceutical sets were compressed with one of the most commonly used excipients, namely microcrystalline cellulose (MCC) and drug Indomethacin. The optical compressibility clearly correlates with the skeletal bulk modulus determined by mercury porosimetry and the recently proposed terahertz lumped structural parameter calculated from terahertz measurements. This lumped structural parameter can be used to analyse the pattern of arrangement of excipient and drug particles in porous pharmaceutical tablets. Therefore, we propose that the optical compressibility can serve as a quality parameter of a pharmaceutical tablet corresponding with the skeletal bulk modulus of the porous tablet, which is related to structural arrangement of the powder particles in the tablet

Drug release from PLGA microparticles can be slowed down by a surrounding hydrogel.

This study aimed to evaluate and better understand the potential impact that a layer of surrounding hydrogel (mimicking living tissue) can have on the drug release from PLGA microparticles. Ibuprofen-loaded microparticles were prepared with an emulsion solvent extraction/evaporation method. The drug loading was about 48%. The surface of the microparticles appeared initially smooth and non-porous. In contrast, the internal microstructure of the particles exhibited a continuous network of tiny pores. Ibuprofen release from single microparticles was measured into agarose gels and well-agitated phosphate buffer pH 7.4. Optical microscopy, scanning electron microscopy, differential scanning calorimetry, X-ray powder diffraction, and X-ray μCT imaging were used to characterize the microparticles before and after exposure to the release media. Importantly, ibuprofen release was much slower in the presence of a surrounding agarose gel, e.g., the complete release took two weeks vs. a few days in well agitated phosphate buffer. This can probably be attributed to the fact that the hydrogel sterically hinders substantial system swelling and, thus, slows down the related increase in drug mobility. In addition, in this particular case, the convective flow in agitated bulk fluid likely damages the thin PLGA layer at the microparticles' surface, giving the outer aqueous phase more rapid access to the inner continuous pore network: Upon contact with water, the drug dissolves and rapidly diffuses out through a continuous network of water-filled channels. Without direct surface access, most of the drug "has to wait" for the onset of substantial system swelling to be released

Resolving the rapid water absorption of porous functionalised calcium carbonate powder compacts by terahertz pulsed imaging

Cost effectiveness, ease of use and patient compliance make pharmaceutical tablets the most popular and widespread form to administer a drug to a patient. Tablets typically consist of an active pharmaceutical ingredient and a selection from various excipients. A novel highly porous excipient, functionalised calcium carbonate (FCC), was designed to facilitate rapid liquid uptake leading to disintegration times of FCC based tablets in the matter of seconds. Five sets of FCC tablets with a target porosity of 45% to 65% in 5% steps were prepared and characterised using terahertz pulsed imaging (TPI). The high acquisition rate (15 Hz) of TPI enabled the analysis of the rapid liquid imbibition of water into these powder compacts. The penetration depth determined from the TPI measurements as a function of time was analysed by the power law and modelled by the Lucas-Washburn (LW) equation. The analysis of the hydraulic radius estimated by fitting the liquid imbibition data to the LW equation demonstrates the impact of the porosity as well as the tortuosity of the pore channels on the liquid uptake performance. The tortuosity was related to the porosity by a geometrical model, which shows that the powder compact is constructed by aggregated particles with low permeability and its principal axis perpendicular to the compaction direction. The consideration of the tortuosity yielded a very high correlation (R2 = 0.96) between the porosity and the hydraulic pore radius. The terahertz data also resolved fluctuations (0.9 to 1.3 Hz) of the liquid movement which become more pronounced and higher in frequency with increasing porosity, which is attributed to the constrictivity of pore channels. This study highlights the strong impact of a tablet's microstructure on its liquid penetration kinetics and thus on its disintegration behaviour

Resolving the rapid water absorption of porous functionalised calcium carbonate powder compacts by terahertz pulsed imaging

Cost effectiveness, ease of use and patient compliance make pharmaceutical tablets the most popular and widespread form to administer a drug to a patient. Tablets typically consist of an active pharmaceutical ingredient and a selection from various excipients. A novel highly porous excipient, functionalised calcium carbonate (FCC), was designed to facilitate rapid liquid uptake leading to disintegration times of FCC based tablets in the matter of seconds. Five sets of FCC tablets with a target porosity of 45% to 65% in 5% steps were prepared and characterised using terahertz pulsed imaging (TPI). The high acquisition rate (15 Hz) of TPI enabled the analysis of the rapid liquid imbibition of water into these powder compacts. The penetration depth determined from the TPI measurements as a function of time was analysed by the power law and modelled by the Lucas-Washburn (LW) equation. The analysis of the hydraulic radius estimated by fitting the liquid imbibition data to the LW equation demonstrates the impact of the porosity as well as the tortuosity of the pore channels on the liquid uptake performance. The tortuosity was related to the porosity by a geometrical model, which shows that the powder compact is constructed by aggregated particles with low permeability and its principal axis perpendicular to the compaction direction. The consideration of the tortuosity yielded a very high correlation (R2 = 0.96) between the porosity and the hydraulic pore radius. The terahertz data also resolved fluctuations (0.9 to 1.3 Hz) of the liquid movement which become more pronounced and higher in frequency with increasing porosity, which is attributed to the constrictivity of pore channels. This study highlights the strong impact of a tablet's microstructure on its liquid penetration kinetics and thus on its disintegration behaviour

A prototype of an optical sensor for the identification of diesel oil adulterated by kerosene

Abstract Background: Liquid fuel adulteration has several far-reaching impacts such as environmental pollution. A widespread practice is typically the adulteration of diesel oil by kerosene. The relatively cheap price of kerosene is probably the most important reason for its usage in illegal adulteration. Herein, we demonstrate the use of a prototype optical sensor for efficient tracking of adulterated diesel oil. Methods: In this study, a prototype of an optical sensor for screening of fake diesel oil is proposed. The device exploits the phenomenon of laser light reflection from a fuel film over a roughened glass plate. The sensing mechanism of the devise is based on the refractive index mismatch between the glass and the fuel sample, and the wetting property of the fuel film over the roughened surface. For the sake of comparison, the refractive index for each of the fuel samples was measured at room temperature with the aid of an automatic temperature controlled Abbe table refractometer. The sensitivity of this prototype optical sensor was tested using training sets of diesel oil samples adulterated with low concentrations of kerosene. Results: Originally, a commercial handheld glossmeter, with a new innovation of a removable sensor head for liquid inspection is presented as a prototype sensor for the screening of possible adulteration of diesel oils with kerosene. The significant difference in the signal readings obtained from carefully prepared training sets of adulterated diesel oil composed of low percentages (5–15%) of kerosene has proven the high sensitivity of the developed sensor. Conclusions: The ability to detect low concentrations of kerosene in diesel using the newly developed hand-held prototype sensor proves its high sensitivity compared to a high-accuracy Abbe refractometer. We envisage that this proposed sensor could, in the future, be made accessible to the authorities as a mobile fake fuel measurement unit