Fluoride Concentration in Dentin of Exfoliated Primary Teeth as a Biomarker for Cumulative Fluoride Exposure

A biomarker for lifetime fluoride exposure would facilitate population-based research and policy making but currently does not exist. This study examined the suitability of primary tooth dentin as a biomarker by comparing dentin fluoride concentration and fluoride exposures. Ninety-nine children's exfoliated primary teeth were collected from 2 fluoridated and 2 fluoride-deficient communities in North Carolina. Coronal dentin was isolated by microdissection and fluoride concentration assayed using the microdiffusion, ion-specific electrode technique. Information on children's fluoride exposures since birth from drinking water, toothpaste, supplements, rinses, food and beverages was collected by a self-reported questionnaire administered to caregivers. Only a small portion of the variance (10%) in incisor dentin fluoride (mean 792, SD 402 mg/kg) was accounted for by the best linear regression model as evaluated by the adjusted R2. A moderate portion of the variance (60%) of molar dentin fluoride (mean 768, SD 489 mg/kg) was predicted by dietary fluoride supplement exposures, community of residence, and frequent tea consumption. Results for molars suggest that primary tooth dentin concentration may prove to be a satisfactory biomarker for fluoride exposure

Extreme S-34 depletions in ZnS at the Mike gold deposit, Carlin Trend, Nevada: Evidence for bacteriogenic supergene sphalerite

We identified submicrometer-sized framboidal sphalerite (ZnS) below the base of supergene oxidation in a Carlin-type gold deposit of Eocene age in Nevada, United States, where the framboidal sphalerite forms a blanket-like body containing >400,000 metric tons of zinc. Framboidal sphalerite <0.1 mum in diameter, formed in the early Miocene, ranges from <0.1 to 0.35 mol% FeS; the delta(34)S values range from -25% to w-70%, the lowest values measured in a marine or terrestrial environment. These S isotope data demonstrate the involvement of sulfate-reducing bacteria and provide the first documentation that sphalerite can form significant supergene sulfide-enrichment blankets

Hierarchical spin-orbital polarisation of a giant Rashba system

The Rashba effect is one of the most striking manifestations of spin-orbit coupling in solids and provides a cornerstone for the burgeoning field of semiconductor spintronics. It is typically assumed to manifest as amomentum-dependent splitting of a single initially spin-degenerate band into two branches with opposite spin polarization. Combining polarization-dependent and resonant angle-resolved photoemission measurementswith density functional theory calculations, we show that the two “spin-split” branches of the model giant Rashba system BiTeI additionally develop disparate orbital textures, each of which is coupled to a distinct spin configuration. This necessitates a reinterpretation of spin splitting in Rashba-like systems and opens new possibilities for controlling spin polarization through the orbital sector.<br/