Longitudinal kinematic imbalances in (anti-)neutrino interactions for improved measurements of nuclear removal energies and the axial vector form factor

Current and future accelerator neutrino oscillation experiments require an improved understanding of nuclear effects in neutrino-nucleus interactions. One important systematic uncertainty is given by potential mismodeling of the removal energy, which biases the reconstruction of the neutrino energy. In this manuscript, we introduce a novel observable for accelerator neutrino oscillation experiments, the visible longitudinal momentum imbalance, reconstructed in charged current quasi-elastic interactions from the outgoing charged lepton and nucleon. Minimally dependent on the neutrino energy and directly sensitive to the removal energy distribution, we demonstrate a method to constrain the latter. Further, we show how the use of the longitudinal imbalance in anti-neutrino interactions in a target containing hydrogen allows for an improved, high-purity selection of the interactions on hydrogen. This approach offers the potential for precise measurements of the nuclear axial vector form factor as well as of the anti-neutrino flux.Comment: 9 pages, 9 figure

GA4GH: International policies and standards for data sharing across genomic research and healthcare.

The Global Alliance for Genomics and Health (GA4GH) aims to accelerate biomedical advances by enabling the responsible sharing of clinical and genomic data through both harmonized data aggregation and federated approaches. The decreasing cost of genomic sequencing (along with other genome-wide molecular assays) and increasing evidence of its clinical utility will soon drive the generation of sequence data from tens of millions of humans, with increasing levels of diversity. In this perspective, we present the GA4GH strategies for addressing the major challenges of this data revolution. We describe the GA4GH organization, which is fueled by the development efforts of eight Work Streams and informed by the needs of 24 Driver Projects and other key stakeholders. We present the GA4GH suite of secure, interoperable technical standards and policy frameworks and review the current status of standards, their relevance to key domains of research and clinical care, and future plans of GA4GH. Broad international participation in building, adopting, and deploying GA4GH standards and frameworks will catalyze an unprecedented effort in data sharing that will be critical to advancing genomic medicine and ensuring that all populations can access its benefits

Longitudinal kinematic imbalances in (anti-)neutrino interactions for improved measurements of nuclear removal energies and the axial vector form factor

Current and future accelerator neutrino oscillation experiments require an improved understanding of nuclear effects in neutrino-nucleus interactions. One important systematic uncertainty is given by potential mismodeling of the removal energy, which biases the reconstruction of the neutrino energy. In this manuscript, we introduce a novel observable for accelerator neutrino oscillation experiments, the visible longitudinal momentum imbalance, reconstructed in charged current quasi-elastic interactions from the outgoing charged lepton and nucleon. Minimally dependent on the neutrino energy and directly sensitive to the removal energy distribution, we demonstrate a method to constrain the latter. Further, we show how the use of the longitudinal imbalance in anti-neutrino interactions in a target containing hydrogen allows for an improved, high-purity selection of the interactions on hydrogen. This approach offers the potential for precise measurements of the nuclear axial vector form factor as well as of the anti-neutrino flux

Longitudinal kinematic imbalances in (anti-)neutrino interactions for improved measurements of nuclear removal energies and the axial vector form factor

International audienceCurrent and future accelerator neutrino oscillation experiments require an improved understanding of nuclear effects in neutrino-nucleus interactions. One important systematic uncertainty is given by potential mismodeling of the removal energy, which biases the reconstruction of the neutrino energy. In this manuscript, we introduce a novel observable for accelerator neutrino oscillation experiments, the visible longitudinal momentum imbalance, reconstructed in charged current quasi-elastic interactions from the outgoing charged lepton and nucleon. Minimally dependent on the neutrino energy and directly sensitive to the removal energy distribution, we demonstrate a method to constrain the latter. Further, we show how the use of the longitudinal imbalance in anti-neutrino interactions in a target containing hydrogen allows for an improved, high-purity selection of the interactions on hydrogen. This approach offers the potential for precise measurements of the nuclear axial vector form factor as well as of the anti-neutrino flux

GA4GH: International policies and standards for data sharing across genomic research and healthcare

The Global Alliance for Genomics and Health (GA4GH) aims to accelerate biomedical advances by enabling the responsible sharing of clinical and genomic data through both harmonized data aggregation and federated approaches. The decreasing cost of genomic sequencing (along with other genome-wide molecular assays) and increasing evidence of its clinical utility will soon drive the generation of sequence data from tens of millions of humans, with increasing levels of diversity. In this perspective, we present the GA4GH strategies for addressing the major challenges of this data revolution. We describe the GA4GH organization, which is fueled by the development efforts of eight Work Streams and informed by the needs of 24 Driver Projects and other key stakeholders. We present the GA4GH suite of secure, interoperable technical standards and policy frameworks and review the current status of standards, their relevance to key domains of research and clinical care, and future plans of GA4GH. Broad international participation in building, adopting, and deploying GA4GH standards and frameworks will catalyze an unprecedented effort in data sharing that will be critical to advancing genomic medicine and ensuring that all populations can access its benefits