A smooth compactification of the space of genus two curves in projective space: via logarithmic geometry and Gorenstein curves

We construct a modular desingularisation of M_{2,n}(P^r,d)^main . The geometry of Gorenstein singularities of genus two leads us to consider maps from prestable admissible covers; with this enhanced logarithmic structure, it is possible to desingularise the main component by means of a logarithmic modification. Both isolated and nonreduced singularities appear naturally. Our construction gives rise to a notion of reduced Gromov–Witten invariants in genus two

A framework to evaluate the effects of organizational resilience on service quality

Disruptions and unexpected turbulences characterize the contemporary service industry and pose greater criticalities to organizations that have concerns about both their survival and their business sustainability. The answer to this challenge is to design an organizational system aimed at enhancing so-called organizational resilience. The aim of this work is to present and test an assessment methodology based on a framework that links key static and dynamic characteristics of firms as resilient systems and relates these characteristics with service quality preservation after disruptions. The framework adopts a set of indicators, namely resilience dimensions, to comprehend the real effects of resilience characteristics with service quality dimensions. Through the analysis of a real case, we provided evidence of how the model can be applied in a backward perspective to understand fault modes of specific events. Results show how inadequacies in terms of resilience characteristics determine losses of service quality, and also how the model can be used as a predictive tool to determine in which area companies should intervene in order to improve resilience and service quality

Physical activity and cancer prevention: a review of current evidence and biological mechanisms

Objective. The main aim of this paper is to review the evidence available from the date of PubMed?s inception to May 2011 for a link between cancer and physical activity (PA) in both animal models and humans. Methods. We decided to select studies that comply with the scheme proposed by the American College of Sports Medicine/ American Heart Association (ACSM/AHA) that distinguish occupational physical activity (OPA) and leisure-time physical activity (LT-PA), further classified in three levels of intensity (low, moderate and heavy) based on the Metabolic Equivalent of Task (MET) index. Results. Considering animal models, there was strong evidence for an inverse association between voluntary wheel exercise and the risk of colon and breast cancer. Regarding human studies, we identified the following main results: 1) colorectum: LT-PA provided an overall colon risk reduction of 13-14%; 2) breast: significant reduction in the frequency of post-menopausal (PMP) cancers in women that practiced heavy and moderate LT-PA; 3) prostate: heavy OPA and LT-PA seemed to reduce the risk of advanced prostate cancers; 4) endometrium: strong protective effect of heavy/moderate LT-PA among overweight/ obese women; 5) lung: inverse relationship between heavy LT-PA and lung cancer in former or current smokers across all histologies. Conclusion. Increased LT-PA is associated with cancer prevention in several organs, but strong biases, such as body mass index (BMI), gender and age, make it difficult to assess which aspects of PA contribute most strongly to the reduced risk. Furthermore, we found few studies that indicated a protective role for OPA in cancer prevention when compared with LT-PA

Stories of Southern Oregon = Communities + Libraries + Museums + University

Collaborations often have the best outcomes because conversations among those with diverse experiences, varied institutional affiliations, and cross-discipline training bring breadth and depth of perspective. The Stories of Southern Oregon project was a good example of how libraries, museums, and academics can work together to surface important historical content, build community, and strengthen relationships. Thanks to a 2017 grant from the National Endowment for the Humanities’ Common Heritage program, Southern Oregon University faculty partnered with the Eagle Point and Ruch branches of the Jackson County Library District and local museums to collect stories and images of heritage work-life like logging, mining, farming, and ranching. Memories of a different time are very much alive in the rural towns of Jackson and Josephine counties, and public libraries and museums are central to the collective heritage of our small communities. This article describes the Stories of Southern Oregon project and how public libraries in Ruch and Eagle Point engaged their communities to bring history to life, and make a real difference to those they serve every day

Framing open innovation in start-ups' incubators: A complexity theory perspective

Recently, concepts and principles from the Complexity Theory (or, generally speaking, the complexity sciences) have been applied as a perspective for capturing the influence of the context, interaction, and adaption in the innovation processes, such as the ones enabled in the business incubators. The purpose of this paper is to implement a frame of reference for understanding the start-ups’ incubator as a complex system where innovation, learning, and self-organization take place. We build on the interfaces between the Complexity Theory (i.e., complexity sciences) and Open Innovation literature to identify principles, patterns, and conditions that frame the incubation practices as simple rules aimed to sustain the innovation process towards the creation of new ventures. Results from the multiple case studies conducted in five incubators show that the features of variety, nonlinear interaction, interdependence, autonomy, and emergence of the incubation process framed as a complex system are enabled in different ways by the combination of the open innovation practices and services provided by the start-ups’ incubators, including the provision of physical infrastructure, access to funding streams, experts/entrepreneurs networking, education/workshops, mentorship, and advice

Field reliability of GaAs emitters for fiber optic telecommunication systems

GaAs based emitters are widely used in telecommunication systems, and will be probably the core of short haul communications, even if a lot of doubts still exist on their reliability and the few available field results are not too optimistic. For these reasons we decided to follow with a particular attention all the problems related to these devices, investigating reliability by means of accelerated tests and of an accurate survey of field troubles. In this paper, we first of all report our field data, coming from more than five years experience, which show that "reasonable" results (in the range of 2000 FITs for LDs), can be obtained with commercially available devices; as a second step, failure analysis allows to localize failures,thus understanding the appropriate corrective actions to be taken. highlighting the specific process report also same For chip related failures, detailed examples are reported, different failure mechanisms, that, when not related to defects, are the same found during accelerated tests; we examples of failures due to interconnections and packaging

Alexithymia, impulsiveness, and psychopathology in Nonsuicidal self-injured adolescents

Introduction: Nonsuicidal self-injury (NSSI) is a multifaceted phenomenon and a major health issue among adolescents. A better understanding of self-injury comorbidities is crucial to improve our ability to assess, treat, and prevent NSSI. Purpose: This study aimed at analyzing some of the psychobehavioral correlates of NSSI: psychological problems, alexithymia, impulsiveness, and sociorelational aspects. Patients and methods: This was a case-control study. The clinical sample (n=33) included adolescents attending our unit for NSSI and other issues; the controls (n=79) were high-school students. Data were collected using six questionnaires: Youth Self-Report, Barratt\u2019s Impulsiveness Scale, Toronto Alexithymia Scale, Children\u2019s Depression Inventory, Symptom Checklist-90-R, and Child Behavior Checklist. Results: Cases scored significantly higher in all questionnaires. Habitual self-injurers scored higher on impulsiveness and alexithymia. The gesture\u2019s repetition seems relevant to the global clinical picture: habitual self-injurers appear more likely to seek help from the sociosanitary services. We found a difference between the self-injurers\u2019 and their parents\u2019 awareness of the disorder. Conclusion: Habitual self-injurers show signs of having difficulty with assessing the consequences of their actions (nonplanning impulsiveness) and the inability to manage their feelings. Given the significantly higher scores found for cases than for controls on all the psychopathological scales, NSSI can be seen as a cross-category psychiatric disorder, supporting the Diagnostic and Statistical Manual of Mental Disorders decision to include it as a pathological entity in its own right

Absences from work among healthcare workers: are they related to influenza shot adherence?

BACKGROUND: The coverage for influenza vaccination among healthcare workers (HCWs) is inadequate in many countries despite strong recommendations; is there evidence that influenza vaccination is effective in preventing absenteeism? Aim of the study is to evaluate the influenza vaccination coverage and its effects on absences from work among HCWs of an Italian academic healthcare trust during the 2017-2018 influenza season. METHODS: We performed a retrospective study to identify predictive characteristics for vaccination, and a retrospective cohort study to establish the effect of vaccination on absences among the vaccinated and non-vaccinated cohorts between December 2017 and May 2018. Overall absence rates over the whole observation period and sub-rates over 14-days intervals were calculated; then comparison between the two groups were conducted applying Chi-square test. RESULTS: Influenza vaccination coverage among 4419 HCWs was 14.5%. Age, university degree, medical care area and physician profile were positively associated with vaccine uptake. Globally during influenza season non-vaccinated HCWs lost 2.47/100 person-days of work compared to 1.92/100 person-days of work among vaccinated HCWs (p\u2009<\u20090.001); significant differences in absences rates resulted when focusing on the influenza epidemic peak. CONCLUSIONS: Factors predicting influenza uptake among HCWs were male sex, working within medical care area and being a physician. Absenteeism among HCWs resulted to be negatively correlated with vaccination against influenza. These findings add evidence to the urgent need to implement better influenza vaccination strategies towards HCWs to tackle vaccine hesitancy among professionals

Critical involvement of calcium-dependent cytosolic phospholipase A2\u3b1 in aortic valve interstitial cell calcification

The involvement of calcium-dependent cytosolic phospholipase A2\u3b1 (cPLA2\u3b1) in aortic valve calcification is not exhaustively elucidated. Here, cPLA2\u3b1 expression in aortic valve interstitial cell (AVIC) pro-calcific cultures simulating either metastatic or dystrophic calcification was estimated by qPCR, Western blotting, and counting of cPLA2\u3b1-immunoreactive cells, with parallel ultrastructural examination of AVIC calcific degeneration. These evaluations also involved pro-calcific AVIC cultures treated with cPLA2\u3b1 inhibitor dexamethasone. cPLA2\u3b1 over-expression resulted for both types of pro-calcific AVIC cultures. Compared to controls, enzyme content was found to increase by up to 300% and 186% in metastatic and dystrophic calcification-like cultures, respectively. Increases in mRNA amounts were also observed, although they were not as striking as those in enzyme content. Moreover, cPLA2\u3b1 increases were time-dependent and strictly associated with mineralization progression. Conversely, drastically lower levels of enzyme content resulted for the pro-calcific AVIC cultures supplemented with dexamethasone. In particular, cPLA2\u3b1 amounts were found to decrease by almost 88% and 48% in metastatic and dystrophic calcification-like cultures, respectively, with mRNA amounts showing a similar trend. Interestingly, these drastic decreases in cPLA2\u3b1 amounts were paralleled by drastic decreases in mineralization degrees, as revealed ultrastructurally. In conclusion, cPLA2\u3b1 may be regarded as a crucial co-factor contributing to AVIC mineralization in vitro, thus being an attractive potential target for designing novel therapeutic strategies aimed to counteract onset or progression of calcific aortic valve diseases