Synthesis of 4-[10H-Phenothiazin-10-yl(1H-tetrazol-5-yl)-methyl]phenol

This present work aims at synthesizing a novel tetrazole from phenothiazine. Phenothiazine is converted into a nitrile by reacting it with 4-hydroxybenzaldehyde, sodium metabisulphite and sodium cyanide. The nitrile on treatment with NaN3/DMF yielded the corresponding tetrazole. The tetrazole obtained was characterized by IR, 1H NMR, EI-MS and elemental analysis

Synthesis, characterization and biological activity of some novel benzimidazole derivatives

<div align="justify">The reaction of <em>o</em>-phenylenediamine with anthranillic acid yield compound 2-(1H-benzo[d]imidazol-2-yl)aniline (AOP). The compound AOP was condensed with aromatic acid chlorides in the presence of pyridine to get compound <em>N</em>-(2-(1H-benzo[d]imidazol-2-yl)phenyl) benzamide (AB). Further it to then treated with PCl5 to get an intermediate compound then reacted with NaN3 to yield compound 2-(2-(5-phenyl-1H-tetrazol-1-yl)phenyl)-1H-benzo[d]imidazole (ABC). The compounds were synthesized in good yields and their structures were confirmed by IR, 1H-NMR, 13C-NMR spectral data and elemental analysis. Antimicrobial activity against bacteria and fungi was studied. The results of preliminary biological tests showed that of these compounds possess good biological activities.</div