Hukum; rancangan klasik untuk membangun masyarakat merdeka

xxxii.; 87 hal.; ill.; 19 c

Premieres notions d'economie politique sociale ou industrielle. Suivies de Ce qu' on voit et ce qu'on ne voit pas par Frederic Bastiat. La science du bonhomme Richard par Benjamin Franklin. Vocabulaire de la lange economique.

LEIDSSTELSELOPLADEN-RUG0

Gemcitabine and glioblastoma: challenges and current perspectives.

Gemcitabine is a nucleoside analog currently used for the treatment of various solid tumors as a single agent or in combination with other chemotherapeutic drugs. Its use against highly aggressive brain tumors (glioblastoma) has been evaluated in preclinical and clinical trials leading to controversial results. Gemcitabine can inhibit DNA chain elongation, is a potent radiosensitizer and it can enhance antitumor immune activity, but it also presents some drawbacks (e.g., short half-life, side effects, chemoresistance). The aim of this review is to discuss the challenges related to the use of gemcitabine for glioblastoma and to report recent studies that suggest overcoming these obstacles opening new perspectives for its use in the field (e.g., gemcitabine derivatives and/or nanomedicines)

Evaluation of lauroyl-gemcitabine-loaded hydrogel efficacy in glioblastoma rat models.

Anticancer drug-loaded hydrogels are a promising strategy for the local treatment of incurable brain tumors such as glioblastoma (GBM). Recently, we demonstrated the efficacy of lauroyl-gemcitabine lipid nanocapsule hydrogel (GemC-LNC) in a U-87 MG xenograft orthotopic mouse model. In this study, we developed a reliable and reproducible surgical procedure to resect orthotopic GBM tumors in rats. GemC-LNC hydrogel integrity was tested after brain administration in rats and its anti-tumor efficacy was tested on a 9L syngeneic orthotopic model. We demonstrated that LNC integrity is maintained at least for one week after local administration of GemC-LNC. GemC-LNC was able to delay the formation of recurrences in 9L tumor-bearing resected rats, demonstrating the efficacy of this nanomedicine hydrogel in this preclinical model. Our results confirm that GemC-LNC, a hydrogel uniquely formed by a nanocarrier and a cytotoxic drug, could be a promising and safe delivery tool for the local treatment of operable GBM tumors