Therapeutic trial of silicone in peptic ulcer

In a controlled double-blind trial of the therapeutic effectiveness of silicone in patients with duodenal ulcer, the silicone tested was shown to be slightly less effective than placebo medication. The relatively good early response of chronically recurring ulcer disease appeared to be due to the emotional impact of “a new treatment of ulcers.”Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44434/1/10620_2005_Article_BF02232021.pd

Absence of gastrointestinal infections in a cohort of patients with Zollinger-Ellison syndrome and other acid hypersecretors receiving long-term acid suppression with lansoprazole

<p>Abstract</p> <p>Background</p> <p>The relationship between proton pump inhibitor therapy and other acid suppressing medications and the risk of gastrointestinal infections remains controversial.</p> <p>Methods</p> <p>Patients enrolled in a long-term trial of lansoprazole for Zollinger-Ellison syndrome and other acid hypersecretory states had interval histories taken every six months regarding hospitalizations or other intercurrent medical conditions. All medications taken were also reviewed at each visit. In addition, available patients were specifically queried during the study period 2006–2007 regarding the development of any gastrointestinal infections, hospitalizations, and prescriptions for antibiotics.</p> <p>Results</p> <p>Ninety patients were enrolled in our long-term study and 81 were available for review. The median basal gastric pH for the cohort after stabilization on therapy was 2.9 and ranged from 1.1 – 8.4 with a median pentagastrin stimulated gastric pH of 1.60 (range 1.0 – 8.2). No patient developed a clinically significant gastrointestinal infection during the study. The median patient years of follow-up were 6.25 years.</p> <p>Conclusion</p> <p>In a cohort of patients with gastric acid hypersecretion in whom acid secretion status was monitored on lansoprazole, all were free of significant gastrointestinal infections on long-term follow-up.</p> <p>Trial registration</p> <p>NCT00204373</p

A STEROID-INDUCED GASTRIC ULCER

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/32509/1/0000599.pd

Silicones in experimental peptic ulceration

In the search for a silicone as uniformly successful as the one used earlier, in preventing and treating experimental peptic ulceration in animals, 30 different silicones were used in pylorus-ligated rats, Mann-Williamson dogs and histamine ulcerated dogs. None were found to be uniformly effective and the initial encouraging results reported by us could not be reproduced with subsequent silicone preparations.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44435/1/10620_2005_Article_BF02232022.pd