Expression of MUC5AC in normal gastric mucosa, intestinal metaplasia and gastric carcinoma by immunohistochemistry

Background: Carcinomas of the stomach are a heterogeneous group of lesions in terms of architecture, pattern of growth, cell differentiation, and histogenesis. Altered MUC5AC expression patterns have been reported previously in intestinal metaplasia as well as in gastric cancer. The aim of the study was to analyse the expression pattern of MUC5AC in normal, pre-neoplastic and neoplastic gastric epithelium.Methods: Formalin fixed paraffin embedded sections of sixty cases which include twenty cases of each normal gastric mucosa, intestinal metaplasia and gastric carcinoma were taken up for the study and subjected to immunohistochemistry using MUC5AC.Results: The intensity of MUC5AC immunostaining in normal gastric mucosa, intestinal metaplasia and gastric carcinoma was evaluated. Immunoreactivity was graded as 0 (negative), ± (trace positive), + (positive) or ++ (strongly positive). Statistical analysis was performed with Chi-Square test and significant differences were noted between these 3 groups (p value <0.05).Conclusions: Authors concluded that MUC5AC expression rates might be good parameters in progression of intestinal metaplasia to gastric carcinoma and might be a good prognostic marker for gastric carcinoma as it is very well implicated in understanding of gastric carcinogenesis

Achievable Sum-rate of variants of QAM over Gaussian Multiple Access Channel with and without security

The performance of next generation wireless systems (5G/6G and beyond) at the physical layer is primarily driven by the choice of digital modulation techniques that are bandwidth and power efficient, while maintaining high data rates. Achievable rates for Gaussian input and some finite constellations (BPSK/QPSK/QAM) are well studied in the literature. However, new variants of Quadrature Amplitude Modulation (QAM) such as Cross-QAM (XQAM), Star-QAM (S-QAM), Amplitude and phase shift keying (APSK), and Hexagonal Quadrature Amplitude Modulation (H-QAM) are not studied in the context of achievable rates for meeting the demand of high data rates. In this paper, we study achievable rate region for different variants of M-QAM like Cross-QAM, H-QAM, Star-QAM and APSK. We also compute mutual information corresponding to the sum rate of Gaussian Multiple Access Channel (G-MAC), for hybrid constellation scheme, e.g., user 1 transmits using Star-QAM and user 2 by H-QAM. From the results, it is observed that S-QAM gives the maximum sum-rate when users transmit same constellations. Also, it has been found that when hybrid constellation is used, the combination of Star-QAM \& H-QAM gives the maximum rate. In the next part of the paper, we consider a scenario wherein an adversary is also present at the receiver side and is trying to decode the information. We model this scenario as Gaussian Multiple Access Wiretap Channel (G-MAW-WT). We then compute the achievable secrecy sum rate of two user G-MAC-WT with discrete inputs from different variants of QAM (viz, X-QAM, H-QAM and S-QAM).It has been found that at higher values of SNR, S-QAM gives better values of SSR than the other variants. For hybrid inputs of QAM, at lower values of SNR, combination of APSK and S-QAM gives better results and at higher values of SNR, combination of HQAM and APSK gives greater value of SSR.Comment: 11 Figures, two tables. Accepted for publication in IEEE International Conference on Signal Processing and Computer Vision (SPCV-2023

Metastatic Pancreatic Adenocarcinoma During Pregnancy.

We present a rare case of metastatic pancreatic adenocarcinoma diagnosed antepartum. A high index of suspicion must be maintained to diagnose pancreatic cancer during pregnancy. We recommend a thorough history and physical and aggressive pursuit of sensitive imaging in patients with persistent symptoms. If pancreatic adenocarcinoma is diagnosed, a multidisciplinary approach that focuses on patient goals should be undertaken. The effect of pregnancy on tumor growth rates is unknown

Clinical profile of malignancies of groin region in our area: a combined retrospective and prospective study

Background: This study involved various malignancies affecting the groin area in all age group of patients and both genders. The aim of the study was to study the various types of malignancies affecting groin, viz. primary or metastatic, and to project their clinical profile.Methods: In this observational study, a total of 145 patients of groin malignancies were studied in department of General and Minimal Invasive Surgery and allied specialties in a tertiary care hospital. The study was retrospective from January 2005 to April 2012 and prospective from May 2012 till 2014. Results: Out of the total of 145 cases almost 95% were metastatic in the groin and primary groin cancers constituted only 4.9% of the cases. Out of 138 tumors that were metastatic in the groin 108 were squamous cell carcinomas followed by malignant melanoma in 28 cases. Most common predisposing factor for development of groin malignancy was use of kangri in our area.Conclusions: Most of the groin malignancies are metastatic to groin and primary cancers at groin are very rare. Kangri use in our part of the world, is the most important predisposing factor leading to squamous cell carcinoma. The management protocol followed in order to treat groin malignancy is surgery of the primary lesion and block dissection of groin.

Relationship between the levels of Serum Thyroid Hormones and the Risk of Breast Cancer

Breast cancer is still one of the leading causes of cancer death in women, but there has been a sustained decline in mortality rates over the last decades the relationship between breast cancer and thyroid diseases is controversial many works have been done in past also. The relation between autoimmune and non-autoimmune thyroid diseases has been investigated in patients with breast cancer and age-matched control individuals without breast or thyroid disease. Determination of serum thyroid hormone and antibody levels was done in 100 breast cancer patients and 75 control individuals. The mean values for thyroid hormones and anti-thyroid peroxidase antibodies were significantly higher in breast cancer patients than in control individuals. Our results indicate an increased prevalence of autoimmune and non-autoimmune thyroid diseases in breast cancer patients. Keywords: breast, cancer, autoimmune thyroid diseases

Primary Fibrosarcoma of the Liver: We Don't Know Much: A Case Report

A 60-year-old lady presented to us with a right upper abdominal mass. With a clinical diagnosis of liver tumor, she was evaluated with abdominal CT, MRI, nuclear scan, tumor markers, USG guided FNAC and other baseline investigations. On evaluation she had a massive right lobe tumor crossing the midline. In view of the ambiguous diagnosis she was subjected to laparotomy where the lesion was judged unresectable and a biopsy was taken. Histopathological examination showed the rare pathology of primary fibrosarcoma of the liver with features of homogeneous, spindle-shaped cells with abundant collagen fibers showing a classic herringbone pattern. Tissue samples were then sent to another referral cancer hospital for immunohistochemistry and immunoreactive vimentin was found in the tumor cells. Electron microscopically, the tumor cells were rich in rough endoplasmic reticulum without a basement membrane, and were surrounded by large amounts of collagen fibers. The fibroblastic character of the tumor cells was suggested by light and electron microscopy

Association of CYP3A5 Gene Polymorphism with Hypertension in Kashmiri Population

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