Effective treatment strategies against Ebola virus

Ebola virus (EBOV), a member of order Mononegavirales is most famous for causing the endemics of hemorrhagic fever in different countries of the world. Various effective treatment for EBOV are available presently but different clinical trials and experimental studies on animal models are ongoing for this purpose. Results from different studies showed that selective vaccines and therapeutic drugs have potential to interfere the viral life events within host cell in order to inhibit its replication. Various pre-clinical trials in this regard are proved successful on non-human primates (NHPs) and found to be significant in inhibiting EBOV infections. It is the need of hour to develop effective vaccines against Ebola virus to combat this problem as soon as possible. The present article is a brief review on potential treatment strategies against Ebola virus

QCD Dynamics and Hadron Production in High-Energy Nuclear Collisions at LHCb

This study investigates dijet and neutral pion production in high-energy nuclear collisions in the LHCb detector. The obtained measurements offer crucial insights into Quantum Chromodynamics(QCD), understanding of parton distribution functions, nuclear structure, and particle production dynamics. Specifically, the nuclear modification factor for neutral pions in proton-lead collisions at 8.16 TeV reveal notable first evidence enhancement in the backward region providing constraints on models of nuclear structure. Furthermore, the inclusive ̄ and ̄-dijet production cross-sections in the forward region of pp collisions at 13 TeV align with next-to-leading order theoretical predictions. These findings on dijet and neutral pion production offer complementary perspectives on PDFs and nuclear structure, which are crucial for comprehending QCD dynamics in high-energy nuclear collisions and refining theoretical models

Nucleon Structure and Soft QCD from LHCb

Since the LHC reached the TeV scale in the high-energy hadron collisions, understanding of soft processes becomes inevitable for the constraining of the high-density regime of QCD. The measurement of the differential cross-section of prompt inclusive production of long-lived charged particles in proton-proton collisions at $\sqrt s=13$ TeV is performed by the LHCb experiment. The cross-section is evaluated as a function of transverse momentum and pseudorapidity and compared with the physics model used in current predictions. Comparison of the proton-proton and proton-lead collisions provides insights into the structure of the initial state. LHCb reports the determination of the nuclear modification factor at previously unexplored parton momentum fractio

Effective treatment strategies against Ebola virus

Ebola virus (EBOV), a member of order Mononegavirales is most famous for causing the endemics of hemorrhagic fever in different countries of the world. Various effective treatment for EBOV are available presently but different clinical trials and experimental studies on animal models are ongoing for this purpose. Results from different studies showed that selective vaccines and therapeutic drugs have potential to interfere the viral life events within host cell in order to inhibit its replication. Various pre-clinical trials in this regard are proved successful on non-human primates (NHPs) and found to be significant in inhibiting EBOV infections. It is the need of hour to develop effective vaccines against Ebola virus to combat this problem as soon as possible. The present article is a brief review on potential treatment strategies against Ebola virus

Impact of interpregnancy intervals on perinatal and neonatal outcomes in a multiethnic Pakistani population

Background: Short birth intervals (SBIs) and long birth intervals (LBIs) have been shown to have serious implications for health of both mothers and their children. This study was aimed to investigate the determinants and reproductive outcome of SBI and LBI in a multiethnic Pakistani population.Methods: In a cross-sectional prospective study design, 2798 women admitted in a tertiary-care hospital in Islamabad for delivery were recruited and data on second or higher birth order deliveries were collected. Birth intervals were defined as short (\u3c24 months) and long (\u3e36 months). The reproductive outcome was defined in terms of perinatal and neonatal mortalities, and neonatal complications. Univariate and multivariate logistic regression analyses were performed.Results: Pregnancies with SBI and LBI were observed in 20% and 24% of 2798 women, respectively. Women with SBI had increased odds of perinatal death [adjusted odd ratio (AOR): 1.50] and neonatal death (AOR: 1.47) as compared to women with optimal birth intervals, while women with LBI had slightly lower odds of perinatal deaths (AOR: 0.96), but increased odds of neonatal deaths (AOR: 1.12). Further, the pregnancies with both SBI and LBI were associated with increased odds of short body length, low birth weight, small head circumference and low APGAR score.Conclusion: Nearly half of all pregnancies do not have optimal birth spacing albeit there is wide heterogeneity in the distribution of BI in various Pakistani ethnicities. Pregnancies with SBI and LBI had high risk of adverse reproductive outcome. Intervention programs for maternal and child health need to emphasize optimal birth spacing