Estudo de caso : merchandising de refrigerantes - case Coca-Cola

Orientador: Zaki Akel SobrinhoMonografia(Especialização) - Universidade Federal do Paraná,Setor de Ciências Sociais Aplicadas, Curso de Especialização em Marketing Empresaria

MULTICOMPONENT SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ANALYSIS OF DELAPRIL AND INDAPAMIDE IN TABLETS

A multicomponent ultraviolet (UV) spectrophotometric method was developed and validated for simultaneous determination of delapril (DEL) and indapamide (IND) in tablets employing the partial least squares regression (PLSR) approach. The PLSR method was developed by a multilevel factorial design using 25 synthetic mixtures of drugs and a significant predict model (p < 0.05) were obtained at 225 nm for DEL (r2 = 0.9992) and 243 nm for IND (r2 = 0.9997). Validation parameters such as the specificity, linearity, precision, accuracy and robustness were evaluated in accordance with the ICH requirements, giving satisfactory results within the acceptable range. The proposed PLSR method was successfully applied for simultaneous determination of DEL and IND in fixed dose combinations and can be used as simple alternative to separation techniques.A multicomponent ultraviolet (UV) spectrophotometric method was developed and validated for simultaneous determination of delapril (DEL) and indapamide (IND) in tablets employing the partial least squares regression (PLSR) approach. The PLSR method was developed by a multilevel factorial design using 25 synthetic mixtures of drugs and a significant predict model (p < 0.05) were obtained at 225 nm for DEL (r2 = 0.9992) and 243 nm for IND (r2 = 0.9997). Validation parameters such as the specificity, linearity, precision, accuracy and robustness were evaluated in accordance with the ICH requirements, giving satisfactory results within the acceptable range. The proposed PLSR method was successfully applied for simultaneous determination of DEL and IND in fixed dose combinations and can be used as simple alternative to separation techniques

Linguística Interacional

O presente capítulo fornece um esboço da Linguística Interacional e sua relevância à Linguística Aplicada. Inclui-se nisso uma pesquisa acerca da emergência da Linguística Interacional, seus conceitos básicos e instrumentos metodológicos, perguntas de pesquisa e desafios futuros da  Linguística Interacional, bem como sua contribuição à Linguística Aplicada. O capítulo termina com uma bibliografia de trabalhos citados e referências relevantes

Evaluation of dispersive liquid–liquid microextraction in the stereoselective determination of cetirizine following the fungal biotransformation of hydroxyzine and analysis by capillary electrophoresis

AbstractWe developed a capillary electrophoresis (CE) and dispersive liquid–liquid microextraction (DLLME) method to stereoselectively analyze hydroxyzine (HZ) and cetirizine (CTZ) in liquid culture media. The CE analyses were performed on an uncoated fused-silica capillary; 50mmolL−1 sodium borate buffer (pH 9.0) containing 0.8% (w/v) S-β-CD was used as the background electrolyte. The applied voltage and temperature were +6kV and 15°C, respectively, and the UV detector was set to 214nm. Chloroform (300µL) and ethanol (400µL) were used as the extraction and disperser solvents, respectively, for the DLLME. Following the formation of a cloudy solution, the samples were subjected to vortex agitation at 2000rpm for 30s and to centrifugation at 3000rpm for 5min. The recoveries ranged from 87.4 to 91.7%. The method was linear over a concentration range of 250–12,500ngmL−1 for each HZ enantiomer (r>0.998) and 125–6250ngmL−1 for each CTZ enantiomer (r>0.998). The limits of quantification were 125 and 250ngmL−1 for CTZ and HZ, respectively. Among the six fungi studied, three species were able to convert HZ to CTZ enantioselectively, particularly the fungus Cunninghamella elegans ATCC 10028B, which converted 19% of (S)-HZ to (S)-CTZ with 65% enantiomeric excess

Deposição palinológica atual em sedimentos de superfície do solo no médio vale do rio Paraíba do Sul (Estados de São Paulo e Rio de Janeiro)

The present investigation aims to contribute to the knowledge of recent pollen deposition in the surface of soils of several types of vegetation, disturbed or not by human activities. In sequence, it intends to establish models of deposition and preservation of palynomorphs in the future. Four sites were selected in the middle valley of Paraíba do Sul river, a region of former coffee plantation: Campinho (municipal district of Bananal, SP), Campo Alegre (municipal district of Arapeí, SP), Fazenda Bahia (municipal district of Resende, RJ) and Cafundó-Colônia (municipal district of Barra Mansa, RJ). The methodology used of samples collection and chemical treatment used the standard methodology in Palynology. The results obtained in all the localities analyzed reflect the current conditions of the regional vegetation, altered by human activities. The localities present a predominance of grasses and ruderal plants, characterizing pasture and grassland vegetation. It was also possible to establish a relationship between the state of preservation of the analyzed palynomorphs, the factors responsible for preservation and the respective environmental implications.O presente trabalho tem como objetivo ampliar o conhecimento sobre a deposição palinológica atual em superfície de solos em várias formações vegetais, alteradas ou não por ação antrópica, visando o posterior estabelecimento de modelos de deposição e preservação de palinomorfos. Para este fim, foram selecionadas quatro localidades de estudo no médio vale do rio Paraíba do Sul, antiga região cafeeira: Campinho (município de Bananal, SP), Campo Alegre (município de Arapeí, SP), Fazenda Bahia (município de Resende, RJ) e Cafundó-Colônia (município de Barra Mansa, RJ). As técnicas utilizadas para coleta e tratamento químico das amostras seguiram o método considerado padrão em Palinologia. Os resultados obtidos em todas as localidades analisadas refletem a condição atual da vegetação regional, alterada por atividades antrópicas, com predomínio de gramíneas e plantas ruderais, caracterizando uma vegetação de campo sujo e de pastagem. Foi possível também estabelecer uma relação entre o estado de preservação dos palinomorfos analisados, os fatores responsáveis pela sua preservação e as respectivas implicações ambientais

Explorando variáveis que afetam a adesão e a qualidade da tarefa de descrever competências utilizando guias instrucionais e oficinas de mapeamento

As competências são o eixo central do modelo de gestão por competências, assim, é essencial que elas sejam bem descritas. Uma boa maneira de realizar isso é solicitando aos próprios colaboradores que descrevam suas competências. Para auxiliar os trabalhadores na descrição das competências, foi elaborado e testado um guia instrucional. O objetivo deste estudo foi: 1) identificar e manipular fatores impactantes na realização da tarefa de descrever competências utilizando um guia instrucional e 2) avaliar a qualidade das competências descritas. Participaram dos estudos 349 servidores componentes de 15 workshops em três órgãos públicos. Ao avaliar o impacto de determinados fatores sobre a adesão ao procedimento de descrever competências, os resultados demonstraram diferenças entre o relato dos servidores e os resultados de uma manipulação experimental. Um exemplo é o fator tempo, indicado pelos servidores como muito impactante sobre a tarefa, mas não confirmado experimentalmente. Os dados não indicaram diferenças significativas entre as competências descritas pelos servidores que apenas participaram dos workshops e servidores que participaram dos workshops e também utilizaram do guia instrucional. Pesquisas subsequentes devem explorar métodos para o aperfeiçoamento de guias e outros instrumentos para impulsionar a participação dos servidores e melhorar a qualidade de competências.Competences are the central axis of the competence management model, so it is essential that they are well described. A good way to do this is by asking employees to describe their competences. To help workers in describing competences, an instructional guide has been developed and tested. The objective of this study was: 1) to identify and manipulate impacting factors in the accomplishment of the task of describing competencies using an instructional guide and 2) to evaluate the quality of the described competences. Participated in the studies 349 members of 15 competency mapping workshops in three public agencies. When evaluating the impact of certain factors on adherence to the procedure of describing competences, the results showed differences between the report of the employees and the results of an experimental manipulation. An example is the time factor, indicated by the employees as very impacting on the task but not confirmed experimentally. The data did not show significant differences between the competences described by the employees that only attended the workshops and employees that participated in the workshops and also used the instructional guide. Subsequent research should explore methods for improving guides and other tools to boost employees engagement and improve the quality of competences

Anthelmintic effect of Stachytarpheta schottiana in Caenorhabditis elegans

Helminthiasis is considered a serious illness in tropical countries. The study of activity of natural products has proven to be an excellent alternative to parasite control. This work evaluated the anthelmintic activity of the crude extract of Stachytarpheta schottiana on viability, movements, reproduction behaviors and morphology of different stages of Caenorhabditis elegans. The extract did not decrease L1 hatching, and the survival of L1-L2 and adults in all tested concentrations. And it did not alter the movements of C. elegans adults and the egg-laying activity and brood size. Chemotaxis behavioral assays showed that C. elegans was not attracted or repelled by the extract. The morphological analysis of different forms showed several alterations as cuticular damages that promoted the detachment from the nematode body. The eggs were degraded or not present in adult bodies treated. The results obtained with the crude extract suggest that several secondary metabolites isolated from S. schottiana have an anthelmintic effect and for this confirmation, future analyses will be necessary

Estilos de liderança e clima organizacional: um estudo de caso em uma instituição pública de ensino superior

Esta pesquisa buscou analisar, por meio da avaliação da percepção de 129 servidores, o estilo de liderança predominante e a sua correlação com o fator “apoio e suporte da chefia do clima organizacional” em institutos de uma universidade pública do norte. Para isso, foi realizada uma pesquisa descritiva correlacional, de natureza quantitativa. A coleta de dados foi feita com o uso de questionários, aplicados de forma presencial. Para o teste de correlação, utilizou-se o coeficiente de correlação de spearman. Como resultado do estudo, predominou o estilo democrático de liderar (70,54%), com o clima organizacional positivamente percebido com média quatro. Entre os estilos correlacionados com o clima, não houve associação ao líder autocrático; foram identificadas correlações positivas e moderadas para o líder democrático; e um declínio na satisfação com variáveis do clima para o estilo liberal