Effect of mixed administration of selenium and fenitrothion on pathomorphological pattern in internal organs in rats

Mixed intoxication in rats with sodium selenite (0.40 ppm) and fenitrothion (40 mg/kg bm.) resulted in pathomorphological changes in stomach, intestine, spleen and cardiac muscle which were more intense than in Cases when the mentionedcompounds were administered singly. When a lower dose of selenium (0.08 ppm) together with fenitrothion (40 mg/kg b.m.) was used there was a decrease of disorders in examined organs. Moreover, the changes were even less intense than when selenium (0.40 ppm) or fenitrothion (40 mg/kg h.m.) were administered as a single toxicant.Thus, it was concluded that selenium at a dose of 0.08 ppm protected the rats by limiting the toxic activity of Ienitrothion