4 research outputs found
Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease
- Author
- Aaltonen M
- Abdur Rahman M
- Abell T
- Abide W. Jr
- Acheatel R
- Achiri P
- Acon J
- Adams T
- Affinito S
- Agarwal S
- Aggarwal K
- Aggarwal R
- Ahlström P
- Ahmad A
- Ahmed M
- Aillon C
- Airaksinen A
- Ait-sadi R
- Akers J
- Al-jumaily J
- Albers C
- Albert M
- Alberti A
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- Alford C
- Algotsson L
- Allen T
- Allworth M
- Almond E
- Aloisi A
- Alternburg C
- Alton M
- Amin J
- Amundson A
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- Andersen M
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- Andresen D
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- Zhao L
- Zhao P
- Zhao R
- Zhao Y
- Zheng Y
- Zheng Z
- Zhi Y
- Zhong H
- Zhong R
- Zhou C
- Zhou Juan
- Zhou Xingyu
- Zhou Yingyuan
- Zhu Wangqin
- Zhu X
- Zhu Y
- Ziefle S
- Zilz N
- Zineldine A
- Zlatewa R
- Zoghbi J
- Zong C
- Zong D
- Zong X
- Zuchelkowski A
- Zulauf N
- Ågårdh A
- Öner A
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
BACKGROUND:
Patients with atherosclerotic vascular disease remain at high risk for cardiovascular events despite effective statin-based treatment of low-density lipoprotein (LDL) cholesterol levels. The inhibition of cholesteryl ester transfer protein (CETP) by anacetrapib reduces LDL cholesterol levels and increases high-density lipoprotein (HDL) cholesterol levels. However, trials of other CETP inhibitors have shown neutral or adverse effects on cardiovascular outcomes.
METHODS:
We conducted a randomized, double-blind, placebo-controlled trial involving 30,449 adults with atherosclerotic vascular disease who were receiving intensive atorvastatin therapy and who had a mean LDL cholesterol level of 61 mg per deciliter (1.58 mmol per liter), a mean non-HDL cholesterol level of 92 mg per deciliter (2.38 mmol per liter), and a mean HDL cholesterol level of 40 mg per deciliter (1.03 mmol per liter). The patients were assigned to receive either 100 mg of anacetrapib once daily (15,225 patients) or matching placebo (15,224 patients). The primary outcome was the first major coronary event, a composite of coronary death, myocardial infarction, or coronary revascularization.
RESULTS:
During the median follow-up period of 4.1 years, the primary outcome occurred in significantly fewer patients in the anacetrapib group than in the placebo group (1640 of 15,225 patients [10.8%] vs. 1803 of 15,224 patients [11.8%]; rate ratio, 0.91; 95% confidence interval, 0.85 to 0.97; P=0.004). The relative difference in risk was similar across multiple prespecified subgroups. At the trial midpoint, the mean level of HDL cholesterol was higher by 43 mg per deciliter (1.12 mmol per liter) in the anacetrapib group than in the placebo group (a relative difference of 104%), and the mean level of non-HDL cholesterol was lower by 17 mg per deciliter (0.44 mmol per liter), a relative difference of -18%. There were no significant between-group differences in the risk of death, cancer, or other serious adverse events.
CONCLUSIONS:
Among patients with atherosclerotic vascular disease who were receiving intensive statin therapy, the use of anacetrapib resulted in a lower incidence of major coronary events than the use of placebo. (Funded by Merck and others; Current Controlled Trials number, ISRCTN48678192 ; ClinicalTrials.gov number, NCT01252953 ; and EudraCT number, 2010-023467-18 .)
A Simulated Annealing Hyper-heuristic for University Course Timetabling Problem Extended Abstract
- Publication venue
- Publication date
- Field of study
The university course timetabling problem involves assigning a given number of events (including lectures, seminars, labs, tutorials, etc) into a limited number of timeslots and rooms subject to given set of constraints. Two primary hard constraints are that no student should be assigned two events in one timeslot and that capacity an
Things Fall Apart Again: Structural Adjustment Programmes in Sub-Saharan Africa
- Author
- Publication venue
- 'Cambridge University Press (CUP)'
- Publication date
- Field of study
Recommended from our members
Abstracts and Workshops 7th National Spinal Cord Injury Conference November 9 – 11, 2017 Fallsview Casino Resort Niagara Falls, Ontario, Canada
- Author
- Adams Jared
- Ahmed Umalkhair
- Ahn Henry
- Alappat Chris
- Alavinia Mohammad
- Alavinia S. Mohammad
- Alizadeh-Meghrazi Milad
- Alizadeh-Meghrazi Milad
- Allison David
- Anthony Burns
- Arbour-Nicitopoulos Kelly
- Arbour-Nicitopoulos Kelly
- Arel Jasmine
- Arora Tarun
- Aspinall Arlene
- Athanasopoulos Peter
- Aubertin-Leheudre Mylène
- Ayas Najib
- Babona-Pilipos Robart
- Bailey K. Alysse
- Bain Patricia
- Baron Justine
- Baron Justine
- Bassett-Gunter Rebecca
- Bauman Craig
- Bayley Mark
- Bayley Mark
- Bergquist Austin J
- Berlowitz David
- Berlowitz David J
- Bilsky Gerald
- Booker Lauren
- Brisbois Louise
- Brisbois Louise
- Brisbois Louise M
- Brooke Jillian
- Brosseau Rachel
- Burns Anthony
- Burns Patricia
- Cadarette Suzanne
- Cappe Shauna
- Caron Jeffrey G
- Carvalho Lívia Pinheiro
- Casey Alan
- Catharine Craven B
- Chan Brian
- Chan Katherine
- Charbonneau Rebecca
- Charlifue Susan
- Chemtob Keryn
- Cheng Christiana
- Cheng Christiana L
- Cornell Stephanie
- Craven B. Catharine
- Craven B. Catharine
- Craven B. Catharine
- Craven B. Catharine
- Craven B. Catharine
- Craven B. Catharine
- Craven B. Catharine
- Craven B. Catharine
- Craven B. Catharine
- Cross Susan
- Curran Dorothyann
- Del Castillo-Valenzuela Mikael F
- Desai Naaz
- Ditor David
- Donaldson Lindsay
- Drew Brian
- Duclos Cyril
- Dvorak Marcel F
- Escalona Castillo Manuel Jose
- Ethans Karen
- Ethans Karen
- Everhart-Skeels Sarah
- Fallah Nader
- Fallah Nader Nader
- Farahani Farnoosh
- Farahani Farnoosh
- Farahani Farnoosh
- Fehlings Michael G
- Fehlings Michael G
- Finkelstein Joel
- Flett Heather
- Flett Heather
- Flett Heather
- Flett Heather
- Flett Heather
- Flett Heather M
- Furlan Julio C
- Furlan Julio C
- Furlan Julio C
- Gabison Sharon
- Gagliardi Julie
- Gagnon Dany H
- Gagnon Dany H
- Gagnon H. Dany
- Gainforth Heather L
- Garai Purbasha
- Garcia-Garcia Martha G
- Gassaway Julie
- Gauthier Cindy
- Giangregorio Lora
- Graco Marnie
- Graham Ian D
- Green Sally
- Grimshaw Jeremy
- Gulasingam Sivakumar
- Gulasingam Sivakumar
- Guy Kristina
- Guy Stacey
- Harris Anne
- Hebert Debbie
- Hicks Audrey
- Hicks Audrey L
- Hillier Loretta M
- Hitzig Sander
- Hitzig Sander
- Hitzig Sander L
- Ho Chester
- Holtz Kaila
- Holyoke Paul
- Holyoke Paul
- Holyoke Paul
- Hong Minna
- Houghton Pamela
- Houghton Pamela
- Houghton Pamela E
- Houlihan Bethlyn
- Howcroft Jennifer
- Howcroft Jeremy
- Humphreys Suzanne
- Iwasa Stephanie N
- Jeji Tara
- Jeske Samantha
- Johnston Gillian
- Jones Maryleen K
- Kairy Dahlia
- Kairy Dahlia
- Kaiser Anita
- Kaiser Anita
- Kaiser Anita
- Kalsi-Ryan Sukhvinder
- Kalsi-Ryan Sukhvinder
- Kalsi-Ryan Sukhvinder
- Kapadia Naaz
- Karelis Antony
- Khan Alia
- Koh Ryan G. L
- Koh Ryan G.L
- Kokotow Melanie
- Krahn Murray
- Kramer John
- Kras-Dupuis Anna
- Kras-Dupuis Anna
- Krassiokov-Enns Dimitri
- Kwon Brian
- Lala Deena
- Lala Deena
- Lanig Indira
- Latimer-Cheung Amy
- Laylor Mark
- Lee Joseph
- Lee Joseph
- Lemay Jean-Francois
- Lemay Jean-François
- Lenz Katie
- Leo Jennifer
- Likitlersuang Jirapat
- Linassi A. Gary
- Linassi Angelo Gary
- Loh Eldon
- MacGillivray Megan
- Mahsa Sadeghi
- Marquez-Chin Cesar
- Marquis Aaron
- Marrocco Stephanie
- Martin Ginis Kathleen
- Martin Ginis Kathleen A
- Masani Kei
- Masani Kei
- Masani Kei
- Mathur Sunita
- Mazzella Filomena
- McBride Christopher B
- McCullum Shane
- McGillivray Colleen
- McLeod Jonathan
- McRae Samantha
- Mehta Swati
- Michalovic Emilie
- Miller Toba
- Milligan James
- Milligan James
- Mills Patricia
- Mills Patricia
- Mills Sandra
- Milosevic Matija
- Mittmann Nicole
- Moineau Bastien
- Mokry Jennifer
- Mokry Jennifer
- Morin Cynthia
- Morris Helen
- Morshead Cindi M
- Mortenson Ben
- Moshe Bondi
- Munro Barry
- Musselman Kristin
- Musselman Kristin
- Musselman Kristin
- Musselman Kristin
- Musselman Kristin E
- Namaka Micheal
- Nash Mark
- Nejatbakhsh Nasrin
- Nicholls Carmel
- Noonan Vanessa
- Noonan Vanessa K
- Noonan Vanessa K
- Noonan Vanessa K
- Noreau Luc
- Nussbaum Ethne
- O'Connell Colleen
- O'Connell Colleen
- O'Shea Roberta
- Oates Alison R
- Olds Timothy
- Omidvar Maryam
- Orr Lyndsay
- Orr Lyndsay
- O’Shea Roberta
- Pakosh Maureen
- Paquet Jerome
- Paquet Jérôme
- Patsakos Eleni
- Patsakos Eleni
- Plashkes Tova
- Popovic Milos
- Popovic Milos R
- Popovic Milos R
- Popovic Milos R
- Popovic Milos R
- Popovic Milos R
- Pujol Clara
- Rivers Carly S
- Rocchi Meredith
- Rocchi Meredith A
- Rocchi Meredith A
- Roy Audrey
- Sabetian Parisa
- Sam Jaya
- Sawatzky Bonita
- Schembri Rachel
- Schneider Patrick
- Schwartz Carolyn
- Scovil Carol
- Scovil Carol
- Shafazand Shirin
- Shafazand Shirin
- Sharma Ritu
- Shaw Rob
- Shaw Robert B
- Shen Tian
- Shinya Masahiro
- Shojaei Mir Hatef
- Short Christine
- Singh Hardeep
- Sleeth Lindsay
- Slonim Karen
- Smith Matt
- Stefan Gabriel
- Stork Matthew J
- Sumitro Elizabeth
- Sweeny Michelle
- Sweet Shane N
- Sweet Shane N
- Sweet Shane N
- Sweet Shane N
- Szefer Elena
- Taran Samantha
- Theiss Renee
- Thiyagarajan Chinnaya
- Tomasone Jennifer
- Townson Andrea
- Truchon Catherine
- Tsai Eve
- Unger Janelle
- Unic Nikola
- Valiante Taufik
- Valika Sakina
- Velayudhan Prashanth
- Ventre Anellina
- Vermette Martin
- Verrier Mary
- Verrier Mary C
- Verrier Mary C
- Verrier Mary C
- Walden Kristen
- West Christopher
- Whitehurst David
- Willms Rhonda
- Wodchis Walter
- Wolfe Dalton
- Wolfe Dalton
- Wolfe Dalton
- Xia Nancy
- Yoo Jaeeun
- Yoo Paul
- Zariffa Jose
- Zariffa José
- Zariffa José
- Zariffa José
- Zee Joanne
- Zelaya Walter
- Zivanovic Vera
- Zivanovic Vera
- Publication venue
- Publication date
- 02/11/2017
- Field of study