Lesson 22: Postmodernism

This lesson covers postmodernism with a focus on artists Cindy Sherman, Jean-Michel Basquiat, Keith Haring, James Turrell, Damien Hirst, Nam June Paik, Kehinde Wiley, and Bruce Nauman

Lesson 01: Introduction to Art Appreciation

This lesson covers the elements and principles of art. Elements of art are the physical parts of the work, including line, shape, form, space, texture, value, color, and time. Principles of art are the ways in which those parts are arranged, including unity/variety, balance, contrast, emphasis, movement, rhythm, and pattern

Lesson 11: Bosch and Other Scenes of the Apocalypse

This lesson covers artworks of scenes from the apocalypse with a focus on Hieronymus Bosch’s Garden of Earthly Delights

Lesson 23: The Postmodern Body in Art

This lesson covers postmodern art that incorporates the body by artists Marina Abramović, Gonzalez-Torres, Nick Cave, and Wangechi Mutu

Exploring the roles of Bzz1 in clathrin-mediated endocytosis

2015 Spring.Includes bibliographical references.Clathrin-mediated endocytosis (CME) is a highly conserved process in eukaryotes. This particular route of endocytosis plays an integral role in virus internalization, nutrient uptake, regulation of signal transduction, and overall cell health. CME can be characterized by three distinct stages: coat formation, cargo binds a receptor on the plasma membrane which leads to the recruitment of coat proteins and the formation of a clathrin coated pit; actin polymerization, globular actin will polymerize in such a way that the vesicle can overcome the turgor pressure of the plasma membrane; and scission and coat disassembly, the vesicle is separated from the plasma membrane and the coat proteins are recycled for the next endocytic event. Initiation of actin polymerization is mediated by the activation of the Arp2/3 complex. Arp2/3 is activated by Las17, the yeast homolog of human WASp (Wiskott-Aldrich Syndrome protein). Las17 interacts with multiple proteins, both activators and inhibitors. The activity of Las17 is inhibited by a protein called Sla1. Sla1 binds the P8-12 region of Las17 and blocks one of two globular actin binding sites. Sla1 and Las17 form a stable complex referred to as SLAC (Sla1, Las17, Actin, and Clathrin) and arrive at the plasma membrane together. This project deals specifically with the interaction between the SLAC complex and the putative activator Bzz1 and explores the possibility that Bzz1 both activates actin polymerization and tubulates the plasma membrane. Understanding the mechanisms that allow clathrin-mediated endocytosis to progress from start to finish is critical. Wiskott-Aldrich Syndrome, hypercholesterolemia, and neurodegenerative disorders can all be tied to defects in CME

Lesson 15: Fragonard through the French Revolution

This lessons covers Rococo artworks by Jean-Honoré Fragonard and Élisabeth Vigée Le Brun and Neoclassical artworks by Jacques Louis David

Lesson 18: On the Dada of Art versus the Dada of War

This lesson covers Dada with a focus on artists Hugo Ball, Marcel Duchamp, Hannah Höch and surrealism with a focus on artists Meret Oppenheim, Man Ray, Salvador Dali

Lesson 05: Ideal Beauty in the Ancient World

This lesson covers ideal beauty in the ancient world by discussing related art and architecture from Mesopotamia, Egypt, Greece, and Rome

Lesson 17 Part 1: Reactions to the Modern World-Introduction and Impressionism

This lessons covers the difference between impressionism and expressionism. Impressionism is represented through artworks by Claude Monet, Pierre-Auguste Renoir, Mary Cassatt, and Edgar Degas

Lesson 09: Michelangelo- From High Renaissance to Mannerism

This lesson covers artworks created between the High Renaissance and Mannerism with a focus on Michelangelo