Zoonotic potential of Salmonella enterica carried by pet tortoises

The prevalence of Salmonella in chelonians is not known in the UK and it is not clear whether such Salmonella strains would be pathogenic for human beings. Some strains, such as members of the Arizonae subgroup, may be unable to cause anything more than very mild disease. To determine the carriage of Salmonella in pet tortoises, cloacal swabs were taken for culture. Salmonella enterica Group D was isolated from 5 of the 89 samples. All five were from the same household of seven tortoises. Salmonella isolates were shown by PCR to carry the invA and spiC genes associated with pathogenicity islands 1 and 2. Each isolate carried both genes indicating they had the genetic basis for disease and enterocyte invasion in human beings. The study indicates a low rate of asymptomatic carriage among the general population of pet tortoises. However, it does suggest that those Salmonella strains colonising the tortoise can carry Salmonella pathogenicity island (SPI)-1 and SPI-2 conferring the potential to cause disease in human beings and other animals

Cosmological dynamics of exponential gravity

We present a detailed investigation of the cosmological dynamics based on $\exp (-R/{\Lambda})$ gravity. We apply the dynamical system approach to both the vacuum and matter cases and obtain exact solutions and their stability in the finite and asymptotic regimes. The results show that cosmic histories exist which admit a double de-Sitter phase which could be useful for describing the early and the late-time accelerating universe.Comment: 17 pages LaTeX, 3 figure

Systematic review of hospital readmissions in stroke patients

Background Previous evidence on factors and causes of readmissions associated with high-impact users of stroke is scanty. The aim of the study was to investigate common causes and pattern of short- and long-term readmissions stroke patients by conducting a systematic review of studies using hospital administrative data. Common risk factors associated with the change of readmission rate were also examined. Methods The literature search was conducted from 15th February to 15th March 2016 using various databases, such as Medline, Embase, and Web of Science. Results There were total of 24 studies (n=2,126,617) included in the review. Only 4 studies assessed causes of readmissions in stroke patients with the follow-up duration from 30 days to 5 years. Common causes of readmissions in majority of the studies were recurrent stroke, infections and cardiac conditions. Common patient-related risk factors associated with increased readmission rate were age and history of coronary heart disease, heart failure, renal disease, respiratory disease, peripheral arterial disease and diabetes. Among stroke-related factors, length of stay of index stroke admission was associated with increased readmission rate, followed by bowel incontinence, feeding tube and urinary catheter. Conclusion Although risk factors and common causes of readmission were identified, but none of the previous studies investigated causes and their sequence of readmissions among high-impact stroke users

NOViSE: a virtual natural orifice transluminal endoscopic surgery simulator

Purpose: Natural Orifice Transluminal Endoscopic Surgery (NOTES) is a novel technique in minimally invasive surgery whereby a flexible endoscope is inserted via a natural orifice to gain access to the abdominal cavity, leaving no external scars. This innovative use of flexible endoscopy creates many new challenges and is associated with a steep learning curve for clinicians. Methods: We developed NOViSE - the first force-feedback enabled virtual reality simulator for NOTES training supporting a flexible endoscope. The haptic device is custom built and the behaviour of the virtual flexible endoscope is based on an established theoretical framework – the Cosserat Theory of Elastic Rods. Results: We present the application of NOViSE to the simulation of a hybrid trans-gastric cholecystectomy procedure. Preliminary results of face, content and construct validation have previously shown that NOViSE delivers the required level of realism for training of endoscopic manipulation skills specific to NOTES Conclusions: VR simulation of NOTES procedures can contribute to surgical training and improve the educational experience without putting patients at risk, raising ethical issues or requiring expensive animal or cadaver facilities. In the context of an experimental technique, NOViSE could potentially facilitate NOTES development and contribute to its wider use by keeping practitioners up to date with this novel surgical technique. NOViSE is a first prototype and the initial results indicate that it provides promising foundations for further development

Solutions to Cosmological Problems with Energy Conservation and Varying c, G and Lambda

The flatness and cosmological constant problems are solved with varying speed of light c, gravitational coupling strength G and cosmological parameter Lambda, by explicitly assuming energy conservation of observed matter. The present solution to the flatness problem is the same as the previous solution in which energy conservation was absent.Comment: 5 pages, Replaced with LaTex file with minor change

Diseases of winter linseed : occurrence, effects and importance

In 1998, a survey of the incidence and severity of diseases was carried out on 30 crops of winter linseed at early flowering and again at crop maturity. Five crops each were selected in south west, east, east Midlands, west Midlands and north of England and from Scotland. Crops were predominantly cv. Oliver (90% crops), grown from certified seed (83%) and sown in September (97%). Pasmo (Mycosphaerella) was the most important disease, affecting leaves of 73% crops at early flowering and 90% crops at maturity. Powdery mildew (70% crops), Alternaria (30% crops) on leaves and Botrytis on capsules (70% crops) were also common. Regional differences were apparent for powdery mildew, which was present in all regions except the southwest, whilst Alternaria predominated in the Midlands. Half of the crops surveyed had received fungicide sprays, but this appeared to have made limited impact on disease severity. Pasmo is a new threat to UK linseed crops and this raises concerns about the threat it poses to spring linsee

Observable Effects of Scalar Fields and Varying Constants

We show by using the method of matched asymptotic expansions that a sufficient condition can be derived which determines when a local experiment will detect the cosmological variation of a scalar field which is driving the spacetime variation of a supposed constant of Nature. We extend our earlier analyses of this problem by including the possibility that the local region is undergoing collapse inside a virialised structure, like a galaxy or galaxy cluster. We show by direct calculation that the sufficient condition is met to high precision in our own local region and we can therefore legitimately use local observations to place constraints upon the variation of "constants" of Nature on cosmological scales.Comment: Invited Festscrift Articl

The Power of General Relativity

We study the cosmological and weak-field properties of theories of gravity derived by extending general relativity by means of a Lagrangian proportional to $R^{1+\delta}$. This scale-free extension reduces to general relativity when $\delta \to 0$. In order to constrain generalisations of general relativity of this power class we analyse the behaviour of the perfect-fluid Friedmann universes and isolate the physically relevant models of zero curvature. A stable matter-dominated period of evolution requires $\delta >0$ or $\delta <-1/4$. The stable attractors of the evolution are found. By considering the synthesis of light elements (helium-4, deuterium and lithium-7) we obtain the bound $-0.017<\delta <0.0012.$ We evaluate the effect on the power spectrum of clustering via the shift in the epoch of matter-radiation equality. The horizon size at matter--radiation equality will be shifted by $\sim 1$ for a value of $\delta \sim 0.0005.$ We study the stable extensions of the Schwarzschild solution in these theories and calculate the timelike and null geodesics. No significant bounds arise from null geodesic effects but the perihelion precession observations lead to the strong bound $\delta =2.7\pm 4.5\times 10^{-19}$ assuming that Mercury follows a timelike geodesic. The combination of these observational constraints leads to the overall bound $0\leq \delta <7.2\times 10^{-19}$ on theories of this type.Comment: 26 pages and 5 figures. Published versio

Structure and stability of the Lukash plane-wave spacetime

We study the vacuum, plane-wave Bianchi $VII{}_{h}$ spacetimes described by the Lukash metric. Combining covariant with orthonormal frame techniques, we describe these models in terms of their irreducible kinematical and geometrical quantities. This covariant description is used to study analytically the response of the Lukash spacetime to linear perturbations. We find that the stability of the vacuum solution depends crucially on the background shear anisotropy. The stronger the deviation from the Hubble expansion, the more likely the overall linear instability of the model. Our analysis addresses rotational, shear and Weyl curvature perturbations and identifies conditions sufficient for the linear growth of these distortions.Comment: Revised version, references added. To appear in Class. Quantum Gra

The Andante Regime of Scalar Field Dynamics

The andante regime of scalar field dynamics in the chaotic inflationary Universe is defined as the epoch when the field is rolling moderately slowly down its interaction potential, but at such a rate that first-order corrections to the slow-roll approximation become important. These conditions should apply towards the end of inflation as the field approaches the global minimum of the potential. Solutions to the Einstein-scalar field equations for the class of power law potentials $V(\phi) \propto \phi^{2n}$ are found in this regime in terms of the inverse error function.Comment: 11 pages of plain Latex, FNAL-Pub-94/226-