Caracterização dos idosos usuários de medicação residentes em instituição de longa permanência

Os objetivos deste estudo foram caracterizar os idosos residentes em uma Instituição de Longa Permanência quanto ao uso de medicamentos e verificar a existência de polifarmácia. Trata-se de estudo descritivo e quantitativo, realizado por meio de dados de um banco originado da pesquisa Perfil de idosos residentes numa Instituição de Longa Permanência para Idosos (ILPIs): proposta de ação de enfermagem/saúde. Foram selecionados 39 idosos que faziam uso de medicação. Os achados evidenciaram predominância de mulheres, com idade entre 80 e 89 anos, que sabem ler e são viúvas. As doenças do aparelho circulatório foram as mais frequentes. Os idosos usavam em média 3,7 medicamentos e 30,8% deles utilizavam polifarmácia. Os medicamentos mais usados foram para as intercorrências do sistema cardiovascular. Verificou-se a presença de medicamentos considerados impróprios para idosos. Espera-se sensibilizar os profissionais de saúde a promoverem o uso racional e cuidadoso de medicamentos para os idosos institucionalizados

Hydrodynamics and mass transfer in aqueous two-phase protein extraction using a continuous perforated rotating disc contactor

continuous perforated rotating disc contactor was used to extract bovine serum albumin (BSA) with aqueous two-phase systems based on polyethylene glycol (PEG) and phosphate salts. The dispersed phase holdup and mass transfer coefficient were determined. It was found that the dispersed phase holdup increased with increasing PEG phase velocity. The overall mass transfer coefficient for BSA was independent of the PEG phase velocity.22321521

Occurrence of anatoxin-a(s) during a bloom of Anabaena crassa in a water-supply reservoir in southern Brazil

Cyanobacterial blooms and the accompanying production of cyanotoxins are a serious global problem. Toxic blooms of Anabaena species are common in lagoons and reservoirs of southern Brazil. Worldwide, species of the genus Anabaena produce the majority of the known hepatotoxins (microcystins) and neurotoxins [anatoxin-a, anatoxin-a(s), and saxitoxins]. This report links a bloom of Anabaena crassa in the Faxinal Reservoir, the main water supply for the city of Caxias do Sul (400,000 inhabitants) in southern Brazil, to the occurrence of anatoxin-a(s) in the water. During the bloom period, the reservoir was strongly stratified, with higher temperatures and a deep anoxic hypolimnion. Two methods for sample concentration (direct and complete extraction) were tested, and direct extraction of samples proved to be more efficient. Water samples collected during the bloom showed 9% acetylcholinesterase inhibition at 50 mg mL−1, corresponding to 0.61μg of anatoxin-a(s) per gram of lyophilized powder. At these concentrations, symptoms of neurotoxicity and mortality were not observed in tests with Swiss albino mice. Although the concentrations of anatoxin-a(s) in the Faxinal Reservoir were low, these results are important because this is the first record of the toxin for A. crassa. Furthermore, this cyanotoxin is not yet included in Brazilian legislation for drinking-water monitoring, because of the lack of information about toxicity levels and risk calculation for oral doses. The data presented here contribute to the basis for the future inclusion of this toxin in Brazilian legislation for drinking-water quality control, and for the development of analytical methods for this toxin