Stationary solution of the ring-spinning balloon in zero air drag using a RBFN based mesh-free method

A technique for numerical analysis of the dynamics of the ring-spinning balloon based on the Radial Basis Function Networks (RBFNs) is presented in this paper. This method uses a 'universal approximator' based on neural network methodology to solve the differential governing equations which are derived from the conditions of the dynamic equilibrium of the yarn to determine the shape of balloon yarn. The method needs only a coarse finite collocation points without any finite element-type discretisation of the domain and its boundary for numerical solution of the governing differential equations. This paper will report a first assessment of the validity and efficiency of the present mesh-less method in predicting the balloon shape across a wide range of spinning conditions

Size-tuneable nanometric MRI contrast agents for the imaging of molecular weight dependent transport processes

Purpose: To evaluate size-tuneable nanomeric glycol-chitosan-DTPA-Gd conjugates as MRI contrast agents for the imaging of molecular weight (MW) dependent transport processes. Material & Methods: Glycol chitosans (GC) – DTPA conjugates of precisely controlled MWs were synthesised and evaluated in mice against Gd-DTPA using times series of high-resolution MRI images of trunk, head, and xenograft flank tumours. All animal studies were approved by the local ethics committee and the UK authorities. Results: GC-DTPA modification ratio was one DTPA per 3.9 – 5.13 of GC monomers. GC-DTAPGd provided overall superior contrast compared to Gd-DTPA with the duration of the enhancement depending on MW (≥ 1h for 40kD). Kidneys showed early enhancement also in the renal pelvis suggesting renal elimination. Imaging of the head with GC-DTPA-Gd allowed detailed anatomical identification of specific blood vessels in particular with the high MW agent. Sequential high-resolution isotropic imaging of established A431 xenograft flank tumours with DTPA-Gd and GC-DTPA-Gd demonstrated that the initial delivery of the contrast agents was well correlated with blood supply. Subsequent tissue transport was primarily by diffusion and was limited by molecular weight. The data also highlight the role of heterogeneity in CA distribution that was again more prominent for the high MW agent. Conclusion: GC-DTPA-Gd with identical physical chemical properties but precisely controlled MW allow isotropic high-resolution three-dimensional imaging of molecular weight dependent transport processes which could potentially lead to clinical biomarkers for molecular weight dependent drug transport and support selection of suitable tumour models for pre-clinical development

Alvin titanium electrical penetrator design, manufacture, and testing : interim report

Under the U.S. Navy's Project TITANES a new titanium alloy pressure hull has been designed, built, and installed for use in the deep-submersible ALVIN. The Woods Hole Oceanographic Institution was assigned the task of designing, procuring and testing the through-hull electrical penetrators for the new sphere. This interim report traces the progress of this Woods Hole program from the initial design stage, through the various phases of manufacture and electrical testing, to the installation of the units in the completed hull, and the numerous laboratory~ pressure tank, and at-sea tests conducted to verify the satisfactory performance of the new penetrators. The results of all laboratory and in-service testing done to date support the conclusion that the performance of the titanium penetrators meets all of the original specifications.Office of Naval Research Contract No. NOr014-73-C-0097 NR 265-10

Patrick Colquhoun, the Scottish Enlightenment and Police Reform in Glasgow in the Late Eighteenth Century

Patrick Colquhoun’s role in pioneering police reform in London has been widely documented. This paper seeks to examine from where his ideas and inspiration on law enforcement were derived. While it is recognised that Colquhoun drew and built upon the works of other police reformers and police models, it is argued that underlying many of his ideas were developments in policing which were taking place in his native Glasgow in the late eighteenth century – ideas, which in turn, were influenced by the intellectual and philosophical revolution known as the Scottish Enlightenment. In exploring this issue, the article will also examine the significant role played by the wider intellectual, commercial and political climate in shaping police reform in Scotland’s largest city.Le rôle pionnier de Patrick Colquhoun dans la réforme de la police londonienne a été largement démontré. Cet article vise à examiner l’origine de son inspiration et de ses idées sur la police. Il est admis que Colquhoun s’est appuyé sur le travail d’autres réformateurs de la police et sur d’autres modèles policiers, mais l’auteur argumente qu’une bonne partie de ses idées provenaient des innovations policières en cours à Glasgow, sa ville natale, à la fin du XVIIIe siècle. Ces innovations étaient elles-mêmes influencées par la révolution philosophique et intellectuelle des Lumières écossaises. Au passage, cet article retrace également le rôle significatif qu’a joué le climat intellectuel, commercial et politique dans la manière dont s’est effectuée la réforme policière dans la principale ville d’Écosse

Examining the efficacy of six published time-lapse imaging embryo selection algorithms to predict implantation to demonstrate the need for the development of specific, in-house morphokinetic selection algorithms.

OBJECTIVE: To study the efficacy of six embryo-selection algorithms (ESAs) when applied to a large, exclusive set of known implantation embryos. DESIGN: Retrospective, observational analysis. SETTING: Fertility treatment center. PATIENT(S): Women undergoing a total of 884 in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatment cycles (977 embryos) between September 2014 and September 2015 with embryos cultured using G-TL (Vitrolife) at 5% O2, 89% N2, 6% CO2, at 37°C in EmbryoScope instruments. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Efficacy of each ESA to predict implantation defined using specificity, sensitivity, positive predictive value (PPV), negative predictive value (NPV), area under the receiver operating characteristic curve (AUC), and likelihood ratio (LR), with differences in implantation rates (IR) in the categories outlined by each ESA statistically analyzed (Fisher's exact and Kruskal-Wallis tests). RESULT(S): When applied to an exclusive cohort of known implantation embryos, the PPVs of each ESA were 42.57%, 41.52%, 44.28%, 38.91%, 38.29%, and 40.45%. The NPVs were 62.12%, 68.26%, 71.35%, 76.19%, 61.10%, and 64.14%. The sensitivity was 16.70%, 75.33%, 72.94%, 98.67%, 51.19%, and 62.33% and the specificity was 85.83%, 33.33%, 42.33%, 2.67%, 48.17%, and 42.33%, The AUC were 0.584, 0.558, 0.573, 0.612, 0.543, and 0.629. Two of the ESAs resulted in statistically significant differences in the embryo classifications in terms of IR. CONCLUSION(S): These results highlight the need for the development of in-house ESAs that are specific to the patient, treatment, and environment. These data suggest that currently available ESAs may not be clinically applicable and lose their diagnostic value when externally applied

Preliminary investigation of the prevalence and implantation potential of abnormal embryonic phenotypes assessed using time-lapse imaging.

This retrospective, single site observational study aimed to delineate five abnormal embryonic developmental phenotypes, assessing their prevalence, development potential and suitability for inclusion in embryo selection models for IVF. In total, 15,819 embryos from 4559 treatment cycles cultured in EmbryoScope® incubators between January 2014 and January 2016 were included. Time-lapse images were assessed retrospectively for five abnormal embryo phenotypes: direct cleavage, reverse cleavage, absent cleavage, chaotic cleavage and cell lysis. The prevalence of each abnormal phenotype was assessed. Final embryo disposition, embryo quality and implantation rate were determined and compared with a control embryo cohort. The collective prevalence for the five abnormal phenotypes was 11.4%; chaotic cleavage and direct cleavage together constituted 9.7%. Implantation rates were 17.4%, 0%, 25%, 2.1% and 0% for direct, reverse, absent, chaotic cleavage and cell lysis, respectively. The overall implantation rate for all abnormal embryos with known implantation status was significantly lower compared with the control population (6.9% versus 38.7%, P < 0.0001). The proportion of good quality embryos in each category of abnormal cleavage remained below 25%. Embryos exhibiting an abnormal phenotype may have reduced developmental capability, manifested in both embryo quality and implantation potential, when compared with embryos of normal phenotype

Adaptive self-organization in a realistic neural network model

Information processing in complex systems is often found to be maximally efficient close to critical states associated with phase transitions. It is therefore conceivable that also neural information processing operates close to criticality. This is further supported by the observation of power-law distributions, which are a hallmark of phase transitions. An important open question is how neural networks could remain close to a critical point while undergoing a continual change in the course of development, adaptation, learning, and more. An influential contribution was made by Bornholdt and Rohlf, introducing a generic mechanism of robust self-organized criticality in adaptive networks. Here, we address the question whether this mechanism is relevant for real neural networks. We show in a realistic model that spike-time-dependent synaptic plasticity can self-organize neural networks robustly toward criticality. Our model reproduces several empirical observations and makes testable predictions on the distribution of synaptic strength, relating them to the critical state of the network. These results suggest that the interplay between dynamics and topology may be essential for neural information processing.Comment: 6 pages, 4 figure