763 research outputs found

    Towards a novel carbon device for the treatment of sepsis

    Get PDF
    Sepsis is a systemic inflammatory response to infection in which the balance of pro- andanti-inflammatory mediators, which normally isolate and eliminate infection, is disrupted[1]. Gram negative sepsis is initiated by bacterial endotoxin release which activatesmacrophages and circulating monocytes to release TNF and IL-1β followed by IL-6 andother inflammatory cytokines [2]. As the disease progresses, an unregulatedinflammatory response results in, tissue injury, haematological dysfunction and organdysfunction. Severe sepsis, involving organ hypoperfusion may be further complicatedby hypotension that is unresponsive to adequate fluid replacement, resulting in septicshock and finally death [3].Despite improvements in anti-microbial and supportive therapies, sepsis remains asignificant cause of morbidity and mortality in ICUs worldwide [4]. The complexity ofprocesses mediating the progression of sepsis suggests that an extracorporeal devicecombining blood filtration with adsorption of a wide range of toxins, and inflammatorymediators offers the most comprehensive treatment strategy. However, no such deviceexists at present. A novel, uncoated, polymer pyrolysed synthetic carbon device isproposed which combines the superior adsorption properties of uncoated activatedcarbons with the capacity to manipulate porous structure for controlled adsorption oftarget plasma proteins and polypeptides [5]. Preliminary haemocompatibility andadsorptive capacity was assessed using a carbon matrix prototype

    The Effect of Stochastic Noise on Quantum State Transfer

    Full text link
    We consider the effect of classical stochastic noise on control laser pulses used in a scheme for transferring quantum information between atoms, or quantum dots, in separate optical cavities via an optical connection between cavities. We develop a master equation for the dynamics of the system subject to stochastic errors in the laser pulses, and use this to evaluate the sensitivity of the transfer process to stochastic pulse shape errors for a number of different pulse shapes. We show that under certain conditions, the sensitivity of the transfer to the noise depends on the pulse shape, and develop a method for determining a pulse shape that is minimally sensitive to specific errors.Comment: 10 pages, 9 figures, to appear in Physical Review

    The WHAM Northern Sky Survey and the Nature of the Warm Ionized Medium in the Galaxy

    Full text link
    The Wisconsin H-Alpha Mapper (WHAM) has completed a velocity-resolved map of diffuse H-alpha emission of the entire northern sky, providing the first comprehensive picture of both the distribution and kinematics of diffuse ionized gas in the Galaxy. WHAM continues to advance our understanding of the physical conditions of the warm ionized medium through observations of other optical emission lines throughout the Galactic disk and halo. We discuss some highlights from the survey, including an optical window into the inner Galaxy and the relationship between HI and HII in the diffuse ISM.Comment: 9 pages, 3 figures. To be published in "How does the Galaxy work?", eds. E.J. Alfaro, E. Perez & J. Franco, Kluwer, held 23-27 June 2003 in Granada, Spain. Higher resolution version available at http://www.astro.wisc.edu/~madsen/prof/pubs.htm

    Magnetic and thermal properties of 4f-3d ladder-type molecular compounds

    Full text link
    We report on the low-temperature magnetic susceptibilities and specific heats of the isostructural spin-ladder molecular complexes L2_{2}[M(opba)]_{3\cdot xDMSOy\cdot yH2_{2}O, hereafter abbreviated with L2_{2}M3_{3} (where L = La, Gd, Tb, Dy, Ho and M = Cu, Zn). The results show that the Cu containing complexes (with the exception of La2_{2}Cu3_{3}) undergo long range magnetic order at temperatures below 2 K, and that for Gd2_{2}Cu3_{3} this ordering is ferromagnetic, whereas for Tb2_{2}Cu3_{3} and Dy2_{2}Cu3_{3} it is probably antiferromagnetic. The susceptibilities and specific heats of Tb2_{2}Cu3_{3} and Dy2_{2}Cu3_{3} above TCT_{C} have been explained by means of a model taking into account nearest as well as next-nearest neighbor magnetic interactions. We show that the intraladder L--Cu interaction is the predominant one and that it is ferromagnetic for L = Gd, Tb and Dy. For the cases of Tb, Dy and Ho containing complexes, strong crystal field effects on the magnetic and thermal properties have to be taken into account. The magnetic coupling between the (ferromagnetic) ladders is found to be very weak and is probably of dipolar origin.Comment: 13 pages, 15 figures, submitted to Phys. Rev.

    HyperCP: A high-rate spectrometer for the study of charged hyperon and kaon decays

    Full text link
    The HyperCP experiment (Fermilab E871) was designed to search for rare phenomena in the decays of charged strange particles, in particular CP violation in Ξ\Xi and Λ\Lambda hyperon decays with a sensitivity of 10410^{-4}. Intense charged secondary beams were produced by 800 GeV/c protons and momentum-selected by a magnetic channel. Decay products were detected in a large-acceptance, high-rate magnetic spectrometer using multiwire proportional chambers, trigger hodoscopes, a hadronic calorimeter, and a muon-detection system. Nearly identical acceptances and efficiencies for hyperons and antihyperons decaying within an evacuated volume were achieved by reversing the polarities of the channel and spectrometer magnets. A high-rate data-acquisition system enabled 231 billion events to be recorded in twelve months of data-taking.Comment: 107 pages, 45 Postscript figures, 14 tables, Elsevier LaTeX, submitted to Nucl. Instrum. Meth.

    Study of the Process e+ e- --> omega pi0 --> pi0 pi0 gamma in c.m. Energy Range 920--1380 MeV at CMD-2

    Full text link
    The cross section of the process e+ e- --> omega pi0 --> pi0 pi0 gamma has been measured in the c.m. energy range 920-1380 MeV with the CMD-2 detector. Its energy dependence is well described by the interference of the rho(770) and rho'(1450) mesons decaying to omega pi0. Upper limits for the cross sections of the direct processes e+ e- --> pi0 pi0 gamma, eta pi0 gamma have been set.Comment: Accepted for publication in PL

    Young and Intermediate-age Distance Indicators

    Full text link
    Distance measurements beyond geometrical and semi-geometrical methods, rely mainly on standard candles. As the name suggests, these objects have known luminosities by virtue of their intrinsic proprieties and play a major role in our understanding of modern cosmology. The main caveats associated with standard candles are their absolute calibration, contamination of the sample from other sources and systematic uncertainties. The absolute calibration mainly depends on their chemical composition and age. To understand the impact of these effects on the distance scale, it is essential to develop methods based on different sample of standard candles. Here we review the fundamental properties of young and intermediate-age distance indicators such as Cepheids, Mira variables and Red Clump stars and the recent developments in their application as distance indicators.Comment: Review article, 63 pages (28 figures), Accepted for publication in Space Science Reviews (Chapter 3 of a special collection resulting from the May 2016 ISSI-BJ workshop on Astronomical Distance Determination in the Space Age

    Search for a W' boson decaying to a bottom quark and a top quark in pp collisions at sqrt(s) = 7 TeV

    Get PDF
    Results are presented from a search for a W' boson using a dataset corresponding to 5.0 inverse femtobarns of integrated luminosity collected during 2011 by the CMS experiment at the LHC in pp collisions at sqrt(s)=7 TeV. The W' boson is modeled as a heavy W boson, but different scenarios for the couplings to fermions are considered, involving both left-handed and right-handed chiral projections of the fermions, as well as an arbitrary mixture of the two. The search is performed in the decay channel W' to t b, leading to a final state signature with a single lepton (e, mu), missing transverse energy, and jets, at least one of which is tagged as a b-jet. A W' boson that couples to fermions with the same coupling constant as the W, but to the right-handed rather than left-handed chiral projections, is excluded for masses below 1.85 TeV at the 95% confidence level. For the first time using LHC data, constraints on the W' gauge coupling for a set of left- and right-handed coupling combinations have been placed. These results represent a significant improvement over previously published limits.Comment: Submitted to Physics Letters B. Replaced with version publishe

    Search for the standard model Higgs boson decaying into two photons in pp collisions at sqrt(s)=7 TeV

    Get PDF
    A search for a Higgs boson decaying into two photons is described. The analysis is performed using a dataset recorded by the CMS experiment at the LHC from pp collisions at a centre-of-mass energy of 7 TeV, which corresponds to an integrated luminosity of 4.8 inverse femtobarns. Limits are set on the cross section of the standard model Higgs boson decaying to two photons. The expected exclusion limit at 95% confidence level is between 1.4 and 2.4 times the standard model cross section in the mass range between 110 and 150 GeV. The analysis of the data excludes, at 95% confidence level, the standard model Higgs boson decaying into two photons in the mass range 128 to 132 GeV. The largest excess of events above the expected standard model background is observed for a Higgs boson mass hypothesis of 124 GeV with a local significance of 3.1 sigma. The global significance of observing an excess with a local significance greater than 3.1 sigma anywhere in the search range 110-150 GeV is estimated to be 1.8 sigma. More data are required to ascertain the origin of this excess.Comment: Submitted to Physics Letters
    corecore