Autoimplantation therapy for the management of extensive molluscumcontagiosum: a novel treatment approach

Background: Molluscumcontagiosum (MC) is a common cutaneous viral infection which usually affects children. Inspite of the multiple treatment options such as curettage, expression, electrodessication and different topical agents, in some cases lesions become extensive and persist for more than 3 to 4 years. The role of immunomodulatory therapy in management of MC has been well documented. Autoimplantation has emerged as a useful immunomodulatory therapy for warts. The objective of the study is to assess the efficacy and safety of autoimplantation in treatment of extensive MC.Methods: Patients of   either sex having more than six MC lesions were included. Molluscum body removed, crushed & implanted in a small dermal pocket as described in cases of warts. Patients were evaluated at four weeks, 12 weeks & subsequent 24 weeks.Results: Twenty two patients completed the study. Complete clearance of the MC was seen in 17 (77.2%) patients, 2 (9.1%) had no response, 1 (4.5%) had partial remission & 2 patients (9.1%) showed recurrence.Conclusions: Autoimplantation may be effective& alternative modalities for extensive MC. However, more randomized controlled trial for automplantation therapy in extensive MC need to be warranted

Autoimplantation therapy for the management of extensive molluscumcontagiosum: a novel treatment approach

Background: Molluscumcontagiosum (MC) is a common cutaneous viral infection which usually affects children. Inspite of the multiple treatment options such as curettage, expression, electrodessication and different topical agents, in some cases lesions become extensive and persist for more than 3 to 4 years. The role of immunomodulatory therapy in management of MC has been well documented. Autoimplantation has emerged as a useful immunomodulatory therapy for warts. The objective of the study is to assess the efficacy and safety of autoimplantation in treatment of extensive MC.Methods: Patients of   either sex having more than six MC lesions were included. Molluscum body removed, crushed & implanted in a small dermal pocket as described in cases of warts. Patients were evaluated at four weeks, 12 weeks & subsequent 24 weeks.Results: Twenty two patients completed the study. Complete clearance of the MC was seen in 17 (77.2%) patients, 2 (9.1%) had no response, 1 (4.5%) had partial remission & 2 patients (9.1%) showed recurrence.Conclusions: Autoimplantation may be effective& alternative modalities for extensive MC. However, more randomized controlled trial for automplantation therapy in extensive MC need to be warranted

Dyskeratosis congenita presenting with dysphagia

Dyskeratosiscongenita (DKC) is a genetically heterogeneous disease of defective telomere maintenance that may demonstrate different patterns of inheritance. It is characterized by thetriad of dystrophy of the nails, leukokeratosis of the oral mucosa, and extensive net-like pigmentation of the skin. We report a case ofDKC who presented with a chief complaint of dysphagia

Prevalence of breast cancer in rural population of Jaipur: a survey-based observational study

Abstract Breast cancer, a global health concern predominantly affecting women, recorded 2.3 million new cases and 685,000 deaths in 2020. Alarmingly, projections suggest that by 2040, there could be over 3 million new cases and 1 million deaths. To assess breast cancer prevalence in 24 rural villages within a 60 km radius of NIMS Hospital, Tala Mod, Jaipur, Rajasthan, North India 303,121. A study involving 2023 participants conducted initial screenings, and positive cases underwent further tests, including ultrasound, mammography, and biopsy. SPSSv28 analysed collected data. Among 2023 subjects, 3 screened positive for breast lumps. Subsequent clinical examination and biopsy identified 1 normal case and 2 with breast cancer, resulting in a prevalence proportion of 0.0009 or 98 per 100,000. This study helps fill gap in breast cancer prevalence data for rural Rajasthan. The results highlight a concerning prevalence of breast cancer in the rural area near NIMS hospital, emphasizing the urgent need for increased awareness, early detection, and better healthcare access. Challenges like limited resources, awareness programs, and delayed diagnosis contribute to this high incidence. To address this, comprehensive approach is necessary, including improved screening programs and healthcare facilities in rural areas. Prioritizing rural healthcare and evidence-based strategies can reduce the burden of breast cancer and improve health outcomes