203 research outputs found
Refugeesβ acts of citizenship in the context of integration in Finland
This study analyses the refugeesβ activity during the integration period in Finland within the framework of acts of citizenship proposed by the British theorist Engin Isin. The purpose is to investigate what acts of citizenship refugees perform to constitute themselves as citizens and what factors prevent them from pursuing acts of citizenship as well as to examine the influence of moving to the Capital region on constituting refugees as citizens. The method of qualitative interview is used for this study. Thirteen interviews, including two paired ones, were conducted between June and October 2019. The interviewees were selected among the clients of the Immigrant Services of the city of Espoo on the criterion of moving to this city after living in another municipality outside the Capital Region of Finland. The results show that during their integration process, refugees are focused on performing the following acts that enable them to constitute themselves as citizens: Finnish language learning, job search, political activity and establishment of social relations. The analysis also shows that the lack of integration conditions outside the Finnish Capital Region and difficulties in obtaining available social services prevent refugees from constituting themselves as citizens during their integration. This research points to the differences in integration conditions in different regions of Finland and brings to the conclusion that although there are organizations providing guidance on access to the Finnish social security system, the understanding of Finnish bureaucracy among the refugee population remains a big challenge. The study also demonstrates that refugees are not passive, but rather put an effort to improve their situation, take the initiative, and thus change the common perception of a refugee
Ultra-high energy cosmic ray investigations by means of EAS muon density measurements
A new approach to investigations of ultra-high energy cosmic rays based on
the ground-level measurements of the spectra of local density of EAS muons at
various zenith angles is considered. Basic features of the local muon density
phenomenology are illustrated using a simple semi-analytical model. It is shown
that muon density spectra are sensitive to the spectrum slope, primary
composition, and to the features of hadronic interaction. New experimental data
on muon bundles at zenith angles from 30 degrees to horizon obtained with the
coordinate detector DECOR are compared with CORSIKA-based simulations. It is
found that measurements of muon density spectra in inclined EAS give
possibility to study characteristics of primary cosmic ray flux in a very wide
energy range from 10^15 to 10^19 eV.Comment: 7 pages, 7 figures. Presented at CRIS-2006, Catania, Italy, May 29 -
June 2, 2006. Accepted for publication in Nucl. Phys. B (Proc. Suppl.
ΠΠΠΠΠ₯ΠΠΠΠΠΠ‘Π’Π¬ ΠΠ ΠΠ’ΠΠ§ΠΠ‘ΠΠΠΠ ΠΠ«Π¨ΠΠΠΠΠ― Π Π£Π‘ΠΠΠΠΠ―Π₯ Π’Π ΠΠΠ‘Π€ΠΠ ΠΠΠ¦ΠΠ ΠΠΠ ΠΠΠΠΠΠΠΠ―
The author analyzes most important characteristics and conditions of critical thinking formation on the basis of historic and contemporary data. The creation, formation and further development of critical thinking is formed by social-historic context, beginning with the Ancient Greece and until the modern society. The author claims for necessity of forming and developing critical thinking as the determining factor of personality development in modern conditions. The process of critical thinking formation becomes especially important during the transition to individual education paradigm. The paper highlights that development of critical thinking as the necessary tool of selection, analysis, systematization and interpretation of information is the condition for transition to individual training. The methodical problems of defining the critical thinking caused by βinflationβ of critical thinking on one end and its βshrinkingβ on the other are shown and partially solved. The most important characteristics of critical thinking are seen as follows: openness, plasticity, goal-orientation, self-reflection and self-skepticism. The author shows the necessity of critical thinkingβs elements, hypothesizing and questioning.ΠΠ° ΠΎΡΠ½ΠΎΠ²Π΅ ΠΈΡΡΠΎΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΈ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠ³ΠΎ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»Π° ΠΏΡΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Ρ Π·Π½Π°ΡΠΈΠΌΡΠ΅ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠΈ ΠΈ ΡΡΠ»ΠΎΠ²ΠΈΡ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΊΡΠΈΡΠΈ- ΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΡΡΠ»Π΅Π½ΠΈΡ, Π²ΠΎΠ·Π½ΠΈΠΊΠ½ΠΎΠ²Π΅Π½ΠΈΠ΅, ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΈ Π΄Π°Π»ΡΠ½Π΅ΠΉΡΠ΅Π΅ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ ΠΊΠΎΡΠΎΡΠΎΠ³ΠΎ ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½ΠΎ ΡΠΎΡΠΈΠ°Π»ΡΠ½ΠΎ-ΠΈΡΡΠΎΡΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΊΠΎΠ½ΡΠ΅ΠΊΡΡΠΎΠΌ, Π½Π°ΡΠΈΠ½Π°Ρ Ρ ΠΡΠ΅Π²Π½Π΅ΠΉ ΠΡΠ΅ΡΠΈΠΈ ΠΈ Π·Π°ΠΊΠ°Π½ΡΠΈΠ²Π°Ρ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΠΌ ΠΎΠ±ΡΠ΅ΡΡΠ²ΠΎΠΌ. ΠΠ±ΠΎΡΠ½ΠΎΠ²Π°Π½Π° Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎΡΡΡ ΡΠΎΡΠΌΠΈ- ΡΠΎΠ²Π°Π½ΠΈΡ ΠΊΡΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΡΡΠ»Π΅Π½ΠΈΡ ΠΊΠ°ΠΊ ΠΎΠΏΡΠ΅Π΄Π΅Π»Ρ- ΡΡΠ΅Π³ΠΎ ΡΠ°ΠΊΡΠΎΡΠ° ΡΠ°Π·Π²ΠΈΡΠΈΡ Π»ΠΈΡΠ½ΠΎΡΡΠΈ Π² ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½- Π½ΡΡ
ΡΡΠ»ΠΎΠ²ΠΈΡΡ
. ΠΡΠΎΠ±Π΅Π½Π½ΠΎ Π·Π½Π°ΡΠΈΠΌΡΠΌ ΠΏΡΠΎΡΠ΅ΡΡ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΊΡΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΡΡΠ»Π΅Π½ΠΈΡ ΡΡΠ°Π½ΠΎΠ²ΠΈΡΡΡ Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ
ΠΏΠ΅ΡΠ΅Ρ
ΠΎΠ΄Π° ΠΊ ΠΏΠ΅ΡΡΠΎΠ½ΠΈΡΠΈΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ ΠΏΠ°ΡΠ°Π΄ΠΈΠ³ΠΌΠ΅ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ. ΠΠ±ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΎ, ΡΡΠΎ ΡΡΠ»ΠΎΠ²ΠΈΠ΅ΠΌ ΠΏΠ΅ΡΠ΅Ρ
ΠΎΠ΄Π° ΠΊ ΠΈΠ½Π΄ΠΈΠ²ΠΈΠ΄ΡΠ°Π»ΡΠ½ΠΎΠΌΡ ΠΎΠ±ΡΡΠ΅Π½ΠΈΡ ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ ΠΊΡΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΡΡΠ»Π΅Π½ΠΈΡ ΠΊΠ°ΠΊ Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎΠ³ΠΎ Π½Π°Π²ΡΠΊΠ° ΠΎΡΠ±ΠΎΡΠ°, Π°Π½Π°Π»ΠΈΠ·Π°, ΡΠΈΡΡΠ΅ΠΌΠ°ΡΠΈΠ·Π°ΡΠΈΠΈ, ΠΈΠ½ΡΠ΅ΡΠΏΡΠ΅ΡΠ°ΡΠΈΠΈ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΈ. ΠΠΎΠΊΠ°Π·Π°Π½Ρ ΠΈ ΡΠ°ΡΡΠΈΡΠ½ΠΎ ΡΡΡΡΠ°Π½Π΅Π½Ρ ΠΌΠ΅ΡΠΎΠ΄ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠ»ΠΎΠΆΠ½ΠΎΡΡΠΈ Π² ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠΈ ΠΊΡΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΡΡΠ»Π΅Π½ΠΈΡ, Π²ΡΠ·Π²Π°Π½Π½ΡΠ΅, Ρ ΠΎΠ΄Π½ΠΎΠΉ ΡΡΠΎΡΠΎΠ½Ρ, Π΅Π³ΠΎ Β«ΡΠ°ΡΡΠΈΡΠ΅Π½ΠΈΠ΅ΠΌΒ», Π° Ρ Π΄ΡΡΠ³ΠΎΠΉ β Β«ΡΡΠΆΠ΅Π½ΠΈΠ΅ΠΌΒ». ΠΡΡΠ²Π»Π΅Π½Ρ Π·Π½Π°ΡΠΈΠΌΡΠ΅ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠΈ ΠΊΡΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΡΡΠ»Π΅Π½ΠΈΡ: ΠΎΡΠΊΡΡΡΠΎΡΡΡ, ΠΏΠ»Π°ΡΡΠΈΡΠ½ΠΎΡΡΡ, ΡΠ΅Π»Π΅ΠΎΡΠΈΠ΅Π½ΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΡΡΡ, ΡΠ°ΠΌΠΎΡΠ΅ΡΠ»Π΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΈ ΡΠ°ΠΌΠΎΡΠΊΠ΅ΠΏΡΠΈΡΠΈΠ·ΠΌ. ΠΡΠΎΠ΄Π΅ΠΌΠΎΠ½ΡΡΡΠΈΡΠΎΠ²Π°Π½Π° Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎΡΡΡ ΡΠ°ΠΊΠΈΡ
ΡΠ»Π΅ΠΌΠ΅Π½ΡΠΎΠ² ΠΊΡΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΡΡΠ»Π΅Π½ΠΈΡ, ΠΊΠ°ΠΊ Π³ΠΈΠΏΠΎΡΠ΅Π·ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΈ Π²ΠΎΠΏΡΠΎΡΠ°Π½ΠΈΠ΅
ΠΡΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΌΡΡΠ»Π΅Π½ΠΈΠ΅ ΠΈ Π΅Π³ΠΎ Π½Π΅ΠΎΠ±Ρ ΠΎΠ΄ΠΈΠΌΠΎΡΡΡ Π΄Π»Ρ ΡΠΈΡΡΠ΅ΠΌΡ Π²ΡΡΡΠ΅Π³ΠΎ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ
Introduction. In modern literature on philosophy, pedagogy, psychology, the need for critical thinking for a person living in modern society, and for a graduate of a higher educational institution, is affirmed.Problem statement. The purpose of the article is to specify the reasons for the need for critical thinking. To achieve the goal at the first stage, the author analyzed the English-language review articles on various aspects of critical thinking.Methodology of the study. At the second step, based on the results of the first one, the most significant features of understanding critical thinking in philosophy (ideal, abstract carrier of critical thinking, emphasis on formal logical thought procedures), psychology (attention to thinking in specific situations, determining the connection between critical thinking and types of behavior, analysis of critical thinking skills in certain situations), pedagogy (orientation to the educational practice , reliance on empirical research).Outcomes. Based on the analysis of the review articles, the most significant coherent characteristics of critical thinking as a process were identified: the ability to fix a problem and to put forward hypotheses for its solution, reasoned analysis of hypotheses, comparison with other options, ability to refuse a preliminary solution to the problem, and others. It was also revealed that βintellectual virtuesβ are necessary for the implementation of critical thinking: the desire for education, responsible reasoning, mental flexibility, rejection of prejudices and intellectual egocentrism.Findings. The analysis of the documents of the World Economic Forum (2016, 2018) showed that critical thinking is included in the list of the main skills of students and professionals.ΠΠ²Π΅Π΄Π΅Π½ΠΈΠ΅. Π ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΉ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΠ΅ ΠΏΠΎ ΡΠΈΠ»ΠΎΡΠΎΡΠΈΠΈ, ΠΏΠ΅Π΄Π°Π³ΠΎΠ³ΠΈΠΊΠ΅, ΠΏΡΠΈΡ
ΠΎΠ»ΠΎΠ³ΠΈΠΈ ΡΡΠ²Π΅ΡΠΆΠ΄Π°Π΅ΡΡΡ Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎΡΡΡ ΠΊΡΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΡΡΠ»Π΅Π½ΠΈΡ Π΄Π»Ρ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°, ΠΆΠΈΠ²ΡΡΠ΅Π³ΠΎ Π² ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΌ ΠΎΠ±ΡΠ΅ΡΡΠ²Π΅, ΠΈ Π΄Π»Ρ Π²ΡΠΏΡΡΠΊΠ½ΠΈΠΊΠ° Π²ΡΡΡΠ΅Π³ΠΎ ΡΡΠ΅Π±Π½ΠΎΠ³ΠΎ Π·Π°Π²Π΅Π΄Π΅Π½ΠΈΡ.ΠΠΎΡΡΠ°Π½ΠΎΠ²ΠΊΠ° Π·Π°Π΄Π°ΡΠΈ. Π¦Π΅Π»Ρ ΡΡΠ°ΡΡΠΈ β ΠΊΠΎΠ½ΠΊΡΠ΅ΡΠΈΠ·Π°ΡΠΈΡ ΠΏΡΠΈΡΠΈΠ½ Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎΡΡΠΈ ΠΊΡΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΡΡΠ»Π΅Π½ΠΈΡ.ΠΠ΅ΡΠΎΠ΄ΠΈΠΊΠ° ΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ»ΠΎΠ³ΠΈΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ. ΠΠ»Ρ Π΄ΠΎΡΡΠΈΠΆΠ΅Π½ΠΈΡ ΡΠ΅Π»ΠΈ Π½Π° ΠΏΠ΅ΡΠ²ΠΎΠΌ ΡΡΠ°ΠΏΠ΅ Π°Π²ΡΠΎΡΠΎΠΌ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ Π°Π½Π°Π»ΠΈΠ· Π°Π½Π³Π»ΠΎΡΠ·ΡΡΠ½ΡΡ
ΡΡΠ°ΡΠ΅ΠΉ-ΠΎΠ±Π·ΠΎΡΠΎΠ², ΠΏΠΎΡΠ²ΡΡΠ΅Π½Π½ΡΡ
ΡΠ°Π·Π»ΠΈΡΠ½ΡΠΌ Π°ΡΠΏΠ΅ΠΊΡΠ°ΠΌ ΠΊΡΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΡΡΠ»Π΅Π½ΠΈΡ. ΠΠ° Π²ΡΠΎΡΠΎΠΌ ΡΠ°Π³Π΅ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² ΠΏΠ΅ΡΠ²ΠΎΠ³ΠΎ Π²ΡΡΠ²Π»Π΅Π½Ρ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ Π·Π½Π°ΡΠΈΠΌΡΠ΅ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΠΏΠΎΠ½ΠΈΠΌΠ°Π½ΠΈΡ ΠΊΡΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΡΡΠ»Π΅Π½ΠΈΡ Π² ΡΠΈΠ»ΠΎΡΠΎΡΠΈΠΈ (ΠΈΠ΄Π΅Π°Π»ΡΠ½ΡΠΉ, Π°Π±ΡΡΡΠ°ΠΊΡΠ½ΡΠΉ Π½ΠΎΡΠΈΡΠ΅Π»Ρ ΠΊΡΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΡΡΠ»Π΅Π½ΠΈΡ, Π°ΠΊΡΠ΅Π½Ρ Π½Π° ΡΠΎΡΠΌΠ°Π»ΡΠ½ΠΎ-Π»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΌΡΡΠ»ΠΈΡΠ΅Π»ΡΠ½ΡΡ
ΠΏΡΠΎΡΠ΅Π΄ΡΡΠ°Ρ
), ΠΏΡΠΈΡ
ΠΎΠ»ΠΎΠ³ΠΈΠΈ (Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅ ΠΊ ΠΌΡΡΠ»Π΅Π½ΠΈΡ Π² ΠΊΠΎΠ½ΠΊΡΠ΅ΡΠ½ΡΡ
ΡΠΈΡΡΠ°ΡΠΈΡΡ
, ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΡΠ²ΡΠ·ΠΈ ΠΊΡΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΡΡΠ»Π΅Π½ΠΈΡ Ρ ΡΠΈΠΏΠ°ΠΌΠΈ ΠΏΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ, Π°Π½Π°Π»ΠΈΠ· Π½Π°Π²ΡΠΊΠΎΠ² ΠΊΡΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΡΡΠ»Π΅Π½ΠΈΡ Π² ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Π½ΡΡ
ΡΠΈΡΡΠ°ΡΠΈΡΡ
), ΠΏΠ΅Π΄Π°Π³ΠΎΠ³ΠΈΠΊΠ΅ (ΠΎΡΠΈΠ΅Π½ΡΠ°ΡΠΈΡ Π½Π° ΠΏΡΠ°ΠΊΡΠΈΠΊΡ ΠΎΠ±ΡΡΠ΅Π½ΠΈΡ, ΠΎΠΏΠΎΡΠ° Π½Π° ΡΠΌΠΏΠΈΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ).Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΠ° ΠΎΡΠ½ΠΎΠ²Π΅ Π°Π½Π°Π»ΠΈΠ·Π° ΡΡΠ°ΡΠ΅ΠΉ-ΠΎΠ±Π·ΠΎΡΠΎΠ² Π²ΡΡΠ²Π»Π΅Π½Ρ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ Π·Π½Π°ΡΠΈΠΌΡΠ΅ Π½Π΅ΠΏΡΠΎΡΠΈΠ²ΠΎΡΠ΅ΡΠΈΠ²ΡΠ΅ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠΈ ΠΊΡΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΡΡΠ»Π΅Π½ΠΈΡ ΠΊΠ°ΠΊ ΠΏΡΠΎΡΠ΅ΡΡΠ°: ΡΠΌΠ΅Π½ΠΈΠ΅ ΡΠΈΠΊΡΠΈΡΠΎΠ²Π°ΡΡ ΠΏΡΠΎΠ±Π»Π΅ΠΌΡ, Π²ΡΠ΄Π²ΠΈΠΆΠ΅Π½ΠΈΠ΅ Π³ΠΈΠΏΠΎΡΠ΅Π· Π΄Π»Ρ Π΅Π΅ ΡΠ΅ΡΠ΅Π½ΠΈΡ, Π°ΡΠ³ΡΠΌΠ΅Π½ΡΠΈΡΠΎΠ²Π°Π½Π½ΡΠΉ Π°Π½Π°Π»ΠΈΠ· Π³ΠΈΠΏΠΎΡΠ΅Π·, ΡΡΠ°Π²Π½Π΅Π½ΠΈΠ΅ Ρ Π΄ΡΡΠ³ΠΈΠΌΠΈ Π²Π°ΡΠΈΠ°Π½ΡΠ°ΠΌΠΈ, Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ ΠΎΡΠΊΠ°Π·Π°ΡΡΡΡ ΠΎΡ ΠΏΡΠ΅Π΄Π²Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠ΅ΡΠ΅Π½ΠΈΡ ΠΏΡΠΎΠ±Π»Π΅ΠΌΡ ΠΈ Π΄Ρ. ΠΡΠΎΠΌΠ΅ ΡΠΎΠ³ΠΎ, ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΎ, ΡΡΠΎ Π΄Π»Ρ ΡΠ΅Π°Π»ΠΈΠ·Π°ΡΠΈΠΈ ΠΊΡΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΡΡΠ»Π΅Π½ΠΈΡ Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΡ Β«ΠΈΠ½ΡΠ΅Π»Π»Π΅ΠΊΡΡΠ°Π»ΡΠ½ΡΠ΅ Π΄ΠΎΠ±ΡΠΎΠ΄Π΅ΡΠ΅Π»ΠΈΒ»: ΡΡΡΠ΅ΠΌΠ»Π΅Π½ΠΈΠ΅ ΠΊ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½Π½ΠΎΡΡΠΈ, ΠΎΡΠ²Π΅ΡΡΡΠ²Π΅Π½Π½ΡΠ΅ ΡΠ°ΡΡΡΠΆΠ΄Π΅Π½ΠΈΡ, ΠΏΠ»Π°ΡΡΠΈΡΠ½ΠΎΡΡΡ, ΠΎΡΠΊΠ°Π· ΠΎΡ ΠΏΡΠ΅Π΄ΡΠ°ΡΡΡΠ΄ΠΊΠΎΠ² ΠΈ ΠΈΠ½ΡΠ΅Π»Π»Π΅ΠΊΡΡΠ°Π»ΡΠ½ΠΎΠΉ ΡΠ³ΠΎΡΠ΅Π½ΡΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΡΡΠΈ.ΠΡΠ²ΠΎΠ΄Ρ. ΠΠ½Π°Π»ΠΈΠ· Π΄ΠΎΠΊΡΠΌΠ΅Π½ΡΠΎΠ² ΠΡΠ΅ΠΌΠΈΡΠ½ΠΎΠ³ΠΎ ΡΠΊΠΎΠ½ΠΎΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠΎΡΡΠΌΠ° (2016, 2018 Π³.) ΠΏΠΎΠΊΠ°Π·Π°Π», ΡΡΠΎ ΠΊΡΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΌΡΡΠ»Π΅Π½ΠΈΠ΅ Π²Ρ
ΠΎΠ΄ΠΈΡ Π² ΠΏΠ΅ΡΠ΅ΡΠ΅Π½Ρ ΠΎΡΠ½ΠΎΠ²Π½ΡΡ
Π½Π°Π²ΡΠΊΠΎΠ² ΠΎΠ±ΡΡΠ°ΡΡΠΈΡ
ΡΡ ΠΈ ΠΏΡΠΎΡΠ΅ΡΡΠΈΠΎΠ½Π°Π»ΠΎΠ²
Detection of 1p19q Deletion by Real-Time Comparative Quantitative PCR
1p/19q (1p and/or 19q) deletions are prognostic factors in oligodendroglial tumors (OT) and predict better survival after both chemotherapy and radiotherapy. While studying 1p/19q status as a potential variable within multivariate prognosis models for OT, we have frequently encountered unknown 1p/19q status within our glioma sample database due to lack of paired blood samples for loss of heterozygosity (LOH) assay and/or failure to perform fluorescence in situ hybridization (FISH). We realized that a 1p and 19q deletion assay that could be reliably performed solely on tumor DNA samples would allow us to fill in these molecular biology data βholesβ. We built recombinant DNA with fragments of the selected βmarkerβ genes in 1p (E2F2, NOTCH2), and 19q (PLAUR) and βreferenceβ genes (ERC2, SPOCK1, and SPAG16 ) and used it as quantification standard in real-time PCR to gain absolute ratios of marker/reference gene copy numbers in tumor DNA samples, thus called comparative quantitative PCR (CQ-PCR). Using CQ-PCR, we identified 1p and/ or 19q deletions in majority of pure low-grade oligodenroglioma (OG) tumors (17/21, 81%), a large portion of anaplastic oligodendroglioma (AO) tumors (6/15, 47%), but rarely found in mixed oligoastrcytomas (OA) tumors (1/8, 13%). These data are consistent with results of LOH and FISH assays generally reported for these tumor types. In addition, 15 out 18 samples showed concordant results between FISH and CQ-PCR. We conclude that CQ-PCR is a potential means to gain 1p/19q deletion information, which prognostic and predictive values of CQ-PCR-derived 1p/19q status will be determined in a future study
ΠΠΈΡΡΠ°Π½ΡΠΈΠΎΠ½Π½ΠΎΠ΅/ΡΠ»Π΅ΠΊΡΡΠΎΠ½Π½ΠΎΠ΅ ΠΎΠ±ΡΡΠ΅Π½ΠΈΠ΅: ΠΌΠΈΠ½ΠΈΠΌΠΈΠ·Π°ΡΠΈΡ ΡΠ»ΠΎΠΆΠ½ΠΎΡΡΠ΅ΠΉ
Having passed a long way of development, distance learning from the category of innovation is going to the one of common sight. The gap in space and (until modern phase) in time has been the intact sign of each stage of its development. Distance learning is also characterized by the presence of technology, dialogue between the learner and the trainer, a high proportion of self-study, formal organization. As it is demonstrated by our study, distance learning in higher education, has a number of problems. To solve them, we proposed the subject-centered approach, since there are always people behind all economic, political, legal, pedagogical, psychological problems of distance learning. After identifying the main difficulties, the ways to minimize them were proposed: permanent two-way communication between teachers and students, instructors and students, teachers and instructors; encouragement and support of communication between students, conducting face-to-face meetings between students and teachers; duplication of academic and organizational information; interaction of students with students-tutors.ΠΡΠΎΠΉΠ΄Ρ Π΄ΠΎΠ»Π³ΠΈΠΉ ΠΏΡΡΡ ΡΠ°Π·Π²ΠΈΡΠΈΡ, Π΄ΠΈΡΡΠ°Π½ΡΠΈΠΎΠ½Π½ΠΎΠ΅ ΠΎΠ±ΡΡΠ΅Π½ΠΈΠ΅ ΠΈΠ· ΡΠ°Π·ΡΡΠ΄Π° ΠΈΠ½Π½ΠΎΠ²Π°ΡΠΈΠΉ ΡΡΠ°Π½ΠΎΠ²ΠΈΡΡΡ ΠΎΠ±ΡΠ΄Π΅Π½Π½ΡΠΌ ΠΈ ΠΏΡΠΈΠ²ΡΡΠ½ΡΠΌ. ΠΠ΅ΠΈΠ·ΠΌΠ΅Π½Π½ΡΠΌ ΠΏΡΠΈΠ·Π½Π°ΠΊΠΎΠΌ ΠΊΠ°ΠΆΠ΄ΠΎΠ³ΠΎ ΠΈΠ· ΡΡΠ°ΠΏΠΎΠ² Π΅Π³ΠΎ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠ°Π·ΡΡΠ² Π² ΠΏΡΠΎΡΡΡΠ°Π½ΡΡΠ²Π΅ ΠΈ (Π΄ΠΎ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠ³ΠΎ ΡΡΠ°ΠΏΠ°) Π²ΠΎ Π²ΡΠ΅ΠΌΠ΅Π½ΠΈ. ΠΠΈΡΡΠ°Π½ΡΠΈΠΎΠ½Π½ΠΎΠ΅ ΠΎΠ±ΡΡΠ΅Π½ΠΈΠ΅ ΡΠ°ΠΊΠΆΠ΅ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΠ΅ΡΡΡ Π½Π°Π»ΠΈΡΠΈΠ΅ΠΌ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΉ, Π΄ΠΈΠ°Π»ΠΎΠ³ΠΎΠΌ ΠΌΠ΅ΠΆΠ΄Ρ ΠΎΠ±ΡΡΠ°Π΅ΠΌΡΠΌ ΠΈ ΠΎΠ±ΡΡΠ°ΡΡΠΈΠΌ, Π²ΡΡΠΎΠΊΠΎΠΉ Π΄ΠΎΠ»Π΅ΠΉ ΡΠ°ΠΌΠΎΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ, ΠΎΡΠΈΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΎΠ²Π°Π½Π½ΠΎΡΡΡΡ. ΠΠ°ΠΊ ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΎ Π½Π°ΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅, Π΄ΠΈΡΡΠ°Π½ΡΠΈΠΎΠ½Π½ΠΎΠ΅ ΠΎΠ±ΡΡΠ΅Π½ΠΈΠ΅ Π² ΡΠΈΡΡΠ΅ΠΌΠ΅ Π²ΡΡΡΠ΅Π³ΠΎ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ ΠΈΠΌΠ΅Π΅Ρ ΡΡΠ΄ ΠΏΡΠΎΠ±Π»Π΅ΠΌ. ΠΠ»Ρ ΠΈΡ
ΡΠ΅ΡΠ΅Π½ΠΈΡ Π½Π°ΠΌΠΈ ΠΏΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½ ΡΡΠ±ΡΠ΅ΠΊΡ-ΡΠ΅Π½ΡΡΠΈΡΠΎΠ²Π°Π½Π½ΡΠΉ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄, ΠΏΠΎΡΠΊΠΎΠ»ΡΠΊΡ Π·Π° Π²ΡΠ΅ΠΌΠΈ ΡΠΊΠΎΠ½ΠΎΠΌΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ, ΠΏΠΎΠ»ΠΈΡΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ, ΠΏΡΠ°Π²ΠΎΠ²ΡΠΌΠΈ, ΠΏΠ΅Π΄Π°Π³ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ, ΠΏΡΠΈΡ
ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΠΏΡΠΎΠ±Π»Π΅ΠΌΠ°ΠΌΠΈ Π΄ΠΈΡΡΠ°Π½ΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΠΎΠ±ΡΡΠ΅Π½ΠΈΡ Π² ΠΈΡΠΎΠ³Π΅ Π²ΡΠ΅Π³Π΄Π° ΡΡΠΎΡΡ Π»ΡΠ΄ΠΈ. ΠΠΎΡΠ»Π΅ Π²ΡΡΠ²Π»Π΅Π½ΠΈΡ ΠΎΡΠ½ΠΎΠ²Π½ΡΡ
ΠΏΡΠΎΠ±Π»Π΅ΠΌ ΠΏΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½Ρ ΡΠΏΠΎΡΠΎΠ±Ρ ΠΈΡ
ΠΌΠΈΠ½ΠΈΠΌΠΈΠ·Π°ΡΠΈΠΈ: ΠΏΠΎΡΡΠΎΡΠ½Π½Π°Ρ Π΄Π²ΡΡΡΠΎΡΠΎΠ½Π½ΡΡ ΡΠ²ΡΠ·Ρ ΠΌΠ΅ΠΆΠ΄Ρ ΠΏΡΠ΅ΠΏΠΎΠ΄Π°Π²Π°ΡΠ΅Π»ΡΠΌΠΈ ΠΈ ΡΡΡΠ΄Π΅Π½ΡΠ°ΠΌΠΈ, ΠΈΠ½ΡΡΡΡΠΊΡΠΎΡΠ°ΠΌΠΈ ΠΈ ΡΡΡΠ΄Π΅Π½ΡΠ°ΠΌΠΈ, ΠΏΡΠ΅ΠΏΠΎΠ΄Π°Π²Π°ΡΠ΅Π»ΡΠΌΠΈ ΠΈ ΠΈΠ½ΡΡΡΡΠΊΡΠΎΡΠ°ΠΌΠΈ; ΡΡΠΈΠΌΡΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΈ ΠΏΠΎΠ΄Π΄Π΅ΡΠΆΠΊΠ° ΠΎΠ±ΡΠ΅Π½ΠΈΡ ΠΌΠ΅ΠΆΠ΄Ρ ΡΡΡΠ΄Π΅Π½ΡΠ°ΠΌΠΈ, ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ ΠΎΡΠ½ΡΡ
Π²ΡΡΡΠ΅Ρ ΡΡΡΠ΄Π΅Π½ΡΠΎΠ² ΠΈ ΠΏΡΠ΅ΠΏΠΎΠ΄Π°Π²Π°ΡΠ΅Π»Π΅ΠΉ; Π΄ΡΠ±Π»ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΡΡΠ΅Π±Π½ΠΎΠΉ ΠΈ ΠΎΡΠ³Π°Π½ΠΈΠ·Π°ΡΠΈΠΎΠ½Π½ΠΎΠΉ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΈ; Π°ΠΊΡΠΈΠ²Π½ΠΎΠ΅ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ ΠΎΠ±ΡΡΠ°ΡΡΠΈΡ
ΡΡ ΡΠΎ ΡΡΡΠ΄Π΅Π½ΡΠ°ΠΌΠΈ-ΡΡΡΡΠΎΡΠ°ΠΌΠΈ
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