Evaluation the helicobacter pylori infection in asthmatic children compared to control group

Background: Asthma is a highly prevalent chronic respiratory disease in children. Moreover, the underlying causes of asthma exacerbation are important because they are effective in controlling and preventing asthma. The aim of this study was to evaluate the helicobacter pylori infection in controlled and uncontrolled asthmatic children compared to healthy children. Methods: This case- control study was done on 120 children aged 6-14 years with moderate to severe asthma. Diagnosis of asthma was performed according to GINA criteria with respect to the history and clinical examination. In addition, 120 healthy children without asthma were considered as the control group. Helicobacter pylori stool antigen test was evaluated for all patients. In addition to the above information, age, sex, duration of asthma and gastrointestinal symptoms were also recorded for each patient. Data were analyzed using SPSS15, Chi-square and Fisher's exact test and T-test. Results: The mean age of children in the asthmatic and healthy children was 8.3±2 and 8.5±2.3, respectively (p=0.479). Totally, 57.5% and 58.3% of children were boys in the control group, and in asthmatic group, respectively. Thirty percent of children in the control group and 8.3% of children with asthma were H. pylori positive (p=0.000). Mean duration of asthma in children with H. pylori positive (3.3±1.55) and H. pylori negative (3.33±1.56) stool antigen showed no significant difference (p=0.944). Conclusions: The results of this study indicated that there was an inverse relation between helicobacter pylori infection and asthma

HBS Ag seroclearance and seroconversion time in patients with chronic hepatitis B infection

Background: Hepatitis B Surface antigen (HBsAg) seroclearance and seroconversion (development of antibodies against HBsAg) can increases the survival of Chronic hepatitis B (CHB) patients. The aim of this study was to determine the percentage and timing of HBsAg seroclearance and seroconversion in patients with chronic hepatitis B infection. Methods: 1026 patients with CHB infection who referred to a private clinic were included. These patients had been followed-up for an average of 15 years. The patients whose HBs Ag was cleared from the blood and remained negative until the end of follow-up were designated as HBs Ag serocleared and the patients whose HBs Ab was positive during follow-upwas designated as HBs Ag seroconverted. The time of seroclearance and seroconversion of patients was recorded. Liver function tests, alpha-fetoprotein (AFP) and Hepatitis B early antigen (HBe Ag) status were extracted from the patients’ medical records. Data were analysis with SPSS 17. Results: The duration of follow-up was from 2 to 410 months and most patients were males (58.2). The survival rate of HBs Ag positivity after 5, 10 and 15 years were 95.6, 89.4 and 80.7, and 98, 93.5 and 84.9 of patients had not yet developed anti-HBs antibodies after 5, 10 and 15 years, respectively. Age, gender and taking medication had no effect on HBs Ag clearance from the blood or anti-HBs production Conclusion: The HBs Ag seroconversion is a rare occurrence, but the incidence of this may increase with time, age and drug consumption. Though there was no relationship in our patients &#160

The prevalence of allergic rhinitis in Iranian children: A systematic review and descriptive meta-analysis

Allergic rhinitis is a very common disorder that affects children. To determine the national prevalence of allergic rhinitis symptoms in Iranian children, we conducted a systematic review and meta-analysis. We conducted a literature search by using the Google Scholar from 1992 until 2012. The search terms were included: Allergic rhinitis, ISAAC and Iran. All the selected studies on children were performed by the International Study of Asthma and Allergies in Childhood protocol. By following the criteria, we gathered 436 articles. The required information from each study includes the authors, date, city, number of children in age groups 6-7 and 13-14. The information was recorded on particularly designed sheets. The data were analyzed by STATA 11. In this study, we analyzed 13 studies. 20668 children were in 6-7 years age group and 22920 were in 13-14 years age group. The pooled prevalence of allergic rhinitis in children 6-7 years of age was 11.9% and in children aged 13-14 was 21.2%. The result shows that the prevalence of allergic rhinitis in Iranian children is high. This information can be used to help allergic rhinitis control. Normal 0 false false false EN-US X-NONE FA /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal" mso-tstyle-rowband-size:0 mso-tstyle-colband-size:0 mso-style-noshow:yes mso-style-priority:99 mso-style-parent:"" mso-padding-alt:0cm 5.4pt 0cm 5.4pt mso-para-margin-top:0cm mso-para-margin-right:0cm mso-para-margin-bottom:10.0pt mso-para-margin-left:0cm line-height:115% mso-pagination:widow-orphan font-size:11.0pt font-family:"Times New Roman","serif" mso-ascii-font-family:"Times New Roman" mso-ascii-theme-font:minor-latin mso-hansi-font-family:"Times New Roman" mso-hansi-theme-font:minor-latin mso-bidi-font-family:"Times New Roman" mso-bidi-theme-font:minor-bidi mso-fareast-language:EN-US

Study the incidence of complications of BCG vaccine in infants of Babol, Mazandaran (2011-2013)

Background: BCG vaccination which is administered to prevent tuberculosis is sometimes associated with serious complications. This study aimed to determine the incidence of complications of BCG vaccination in Babol. Methods: All infants who received BCG vaccination between 2011-2013 in health centers of Babol entered the study. Data regarding complications of vaccine were extracted according to the National Inventory of babies. All complicated cases were confirmed by the Academic Committee to review the adverse consequences of the vaccine. Results: Among the 15984 vaccinated neonates, 150 (0.93%) cases presented lymphadenitis. 46.5% were females and 53.5% were males 43% were rural residents and 57% were urban residents. No cases of lymphadenitis including 1% of lymphadenitis with abscess formation were recovered without treatment. Disseminated infection occurred in 3 cases of immune deficient patients who responded to the treatment. Most complications occurred during 4 months after vaccination. Conclusion: According to the results of this study, the prevalence of lymphadenitis in Babol was higher than the standard of WHO. This may be attributed to type and vaccine storage and injection technique. These findings justify further training of health-center workers

The Prevalence of Asthma, Allergic Rhinitis and Eczema in North of Iran: the International Study of Asthma and Allergies in Childhood (ISAAC)

Objective: Asthma, allergic rhinitis and eczema as a common chronic disorder in childhood, has many epidemiologic variations in different geographic areas. Uniform and standard epidemiologic researches are able to clear and modify scientific questions in this field. We carried out this study to determine the prevalence and intensity of pediatric allergic disease in our region. Material & Methods: This analytical-cross sectional study was performed on 2 groups of children; the first group aged 6-7 years (n=3240) and the second group aged 12-14 years (n=3254) during 2002-03. According to ISAAC programming, sample size consisted of 3000 children in each group. From all students 99.3% of primary students and 88.8% of guidance students entered into study. Data was gathered by ISAAC first phase questionnaire and analyzed by SPSS 10 and Chi square test. Findings: The 12-month prevalence rates of symptoms were as follow: wheezing 16.8% and 21.7%, allergic rhinitis symptoms 14.5% and 19.9% and atopic dermatitis symptoms 4.5% and 8.2%, for younger and older age group, respectively. The prevalence of wheezing and current wheeze did not show differences according to sex (P>0.05) but it was significantly higher in students of guidance school (P<0.05). The prevalence of previous history of asthma, speech disorders, wheezing after physical exercises and dry cough at night, rhinoconjuntivitis, recurrent rhinitis, eczema with pruritus, recurrent lesions and history of eczema was significantly higher in boys and in students of guidance school (P<0.05). The prevalence of flexor lesion did not show a significant difference according to age (P>0.05) but in boys it was higher than in the girls (P<0.05). Conclusion: According to our findings asthma, allergic rhinitis and eczema have a moderate prevalence in this region of our countr