627 research outputs found
The Secular Trend in the Incidence of Hemorrhagic Stroke in the Region of Osijek, Eastern Croatia in the Period 1988ā2000 ā A Hospital Based Study
The purpose of the study was to establish the possible environmental influences in
the observed peculiar rising and falling oscillations in the numbers of hemorrhagic
stroke (HS) in Eastern Croatia (region of Osijek) during the last thirteen-yearsā period
(1988ā2000). In this period 1,222 HS were registered and treated. A constant increase in
the incidence of HS was observed, from 60 (in 1988) to 139 (in 1998), with an average
annual proportion of 16.5% of all stroke cases. A sharp increase in proportion of HS in
total stroke incidence was recorded during the war in Croatia (1991ā1995), with a peak
incidence of 27.4% in 1993. Typical hypertensive intracerebral hemorrhage (ICH) was
the most common (57.1%), atypical ICH occurred in 26.4%, subarachnoid hemorrhage
(SAH) in 16.5%. Analysis of the annual number of hypertensive-ICH and SAH disclosed
peculiar rising and falling oscillations. These variations were in correlation with heavy
living conditions. During the war-period the SAH incidence sharply rose. Immediately
after the war it suddenly decreased. The authors named this phenomenon a Ā»pool depletion
Ā«, supposing the relatively stable proportion of the bearers of aneurysms in population.
The observed variations seem to be the consequence of the war stress and other negative
psychosocial and economic factors in post-war period, which increases the risk for
SAH and typical hypertensive-ICH through complex pathophysiological mechanisms
The Secular Trend in the Incidence of Hemorrhagic Stroke in the Region of Osijek, Eastern Croatia in the Period 1988ā2000 ā A Hospital Based Study
The purpose of the study was to establish the possible environmental influences in
the observed peculiar rising and falling oscillations in the numbers of hemorrhagic
stroke (HS) in Eastern Croatia (region of Osijek) during the last thirteen-yearsā period
(1988ā2000). In this period 1,222 HS were registered and treated. A constant increase in
the incidence of HS was observed, from 60 (in 1988) to 139 (in 1998), with an average
annual proportion of 16.5% of all stroke cases. A sharp increase in proportion of HS in
total stroke incidence was recorded during the war in Croatia (1991ā1995), with a peak
incidence of 27.4% in 1993. Typical hypertensive intracerebral hemorrhage (ICH) was
the most common (57.1%), atypical ICH occurred in 26.4%, subarachnoid hemorrhage
(SAH) in 16.5%. Analysis of the annual number of hypertensive-ICH and SAH disclosed
peculiar rising and falling oscillations. These variations were in correlation with heavy
living conditions. During the war-period the SAH incidence sharply rose. Immediately
after the war it suddenly decreased. The authors named this phenomenon a Ā»pool depletion
Ā«, supposing the relatively stable proportion of the bearers of aneurysms in population.
The observed variations seem to be the consequence of the war stress and other negative
psychosocial and economic factors in post-war period, which increases the risk for
SAH and typical hypertensive-ICH through complex pathophysiological mechanisms
ZnaÄaj atestiranja ureÄaja za aplikaciju sredstava za zaÅ”titu bilja
In Serbia, since 1999, the Law on providing services in the field of plant
protection which regulates mandatory inspection of sprayers and mist blowers in use.
Plant protection law is to regulate the field of pesticide application. Pass laws are
harmonized with the EU directive 91/414/EEC, and shall also include the article on
mandatory inspection of sprayers and mist blowers. The main aim of the work is to
inform and prepare the machines for users of plant protection products and control of
the equipment and devices to pass the required control of technical accuracy of
machines. The ways are given, organization and the results of mandatory inspection of
sprayers in the developed European countriesU Srbiji od 1999 godine Zakonom o pružanju usluga u oblasti zaŔtite bilja
predviÄa se obavezna provera prskalica i oroÅ”ivaÄa kao i Zakonom o zaÅ”titi bilja oblast
primene pesticida se detaljnije reguliÅ”e. Doneti zakoni su usklaÄeni sa EU 91/414EEZ, i
odnose se na obaveznu kontrolu prskalica i oroÅ”ivaÄa. Cilj rada je da informiÅ”e i
pripremi korisnike maÅ”ina za zaÅ”titu bilja, na obaveznu kontrolu tehniÄke ispravnosti.
Navedeni su naÄini organizacije i neki rezultati obaveznog pregleda prskalica u
razvijenim evropskim zemljama
Upfront dexrazoxane for the reduction of anthracycline-induced cardiotoxicity in adults with preexisting cardiomyopathy and cancer: a consecutive case series
Abstract
Background
Cardiotoxicity associated with anthracycline-based chemotherapies has limited their use in patients with preexisting cardiomyopathy or heart failure. Dexrazoxane protects against the cardiotoxic effects of anthracyclines, but in the USA and some European countries, its use had been restricted to adults with advanced breast cancer receiving a cumulative doxorubicin (an anthracycline) dose >ā300āmg/m2. We evaluated the off-label use of dexrazoxane as a cardioprotectant in adult patients with preexisting cardiomyopathy, undergoing anthracycline chemotherapy.
Methods
Between July 2015 and June 2017, five consecutive patients, with preexisting, asymptomatic, systolic left ventricular (LV) dysfunction who required anthracycline-based chemotherapy, were concomitantly treated with off-label dexrazoxane, administered 30āmin before each anthracycline dose, regardless of cancer type or stage. Demographic, cardiovascular, and cancer-related outcomes were compared to those of three consecutive patients with asymptomatic cardiomyopathy treated earlier at the same hospital without dexrazoxane.
Results
Mean age of the five dexrazoxane-treated patients and three patients treated without dexrazoxane was 70.6 and 72.6āyears, respectively. All five dexrazoxane-treated patients successfully completed their planned chemotherapy (doxorubicin, 280 to 300āmg/m2). With dexrazoxane therapy, changes in LV systolic function were minimal with mean left ventricular ejection fraction (LVEF) decreasing from 39% at baseline to 34% after chemotherapy. None of the dexrazoxane-treated patients experienced symptomatic heart failure or elevated biomarkers (cardiac troponin I or brain natriuretic peptide). Of the three patients treated without dexrazoxane, two received doxorubicin (mean dose, 210āmg/m2), and one received daunorubicin (540āmg/m2). Anthracycline therapy resulted in a marked reduction in LVEF from 42.5% at baseline to 18%. All three developed symptomatic heart failure requiring hospitalization and intravenous diuretic therapy. Two of them died from cardiogenic shock and multi-organ failure.
Conclusion
The concomitant administration of dexrazoxane in patients with preexisting cardiomyopathy permitted successful delivery of anthracycline-based chemotherapy without cardiac decompensation. Larger prospective trials are warranted to examine the use of dexrazoxane as a cardioprotectant in patients with preexisting cardiomyopathy who require anthracyclines.https://deepblue.lib.umich.edu/bitstream/2027.42/147463/1/40959_2019_Article_36.pd
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