The role of AmtB, GlnK and glutamine synthetase in regulation of transcription factor tnra in bacillus subtilis

The nitrogen is a macroelement for all alive cells, from bacteria to animals. Although NH3/NH4 are highly toxic to animal, they are the preferred source of nitrogen for the most microorganisms and are assimilated by glutamine synthetase in the GOGAT cycle. The nitrogen limitation triggers a number of regulatory processes and activates many genes, providing the utilizing of alternative nitrogen sources. In Bacillus subtilis the genes of nitrogen metabolism are regulated by the transcription factor TnrA. In a cells it is bound to AmtB-GlnK proteins, the interaction with Glutamine synthetase (GS) represses its DNA-binding activity. Here we show the lack of AmtB leads to the nitrogen deficiency in a cell and, consequently, the increased expression of TnrA-de-pendent genes. In the lack of GlnK the transcription factor TnrA is constitutive bound to GS, the TnrA activity is repressed even under nitrogen limit conditions. Apparently, the TnrA activity is subjected to permanent repression by GS. In the absence of GS, the TnrA activity is strongly higher in compare to control, even under nitrogen limitation, when GS is active. These data allow to suggest that TnrA activity is regulated by the competitive binding to GlnK and GS

Indices for Superconformal Field Theories in 3,5 and 6 Dimensions

We present a trace formula for a Witten type Index for superconformal field theories in d=3,5 and 6 dimensions, generalizing a similar recent construction in d=4. We perform a detailed study of the decomposition of long representations into sums of short representations at the unitarity bound to demonstrate that our trace formula yields the most general index (i.e. quantity that is guaranteed to be protected by superconformal symmetry alone) for the corresponding superalgebras. Using the dual gravitational description, we compute our index for the theory on the world volume of N M2 and M5 branes in the large N limit. We also compute our index for recently constructed Chern Simons theories in three dimensions in the large N limit, and find that, in certain cases, this index undergoes a large N phase transition as a function of chemical potentials.Comment: a small typo corrected, 46 page

Significant delay of lethal outcome in cancer patients due to peroral administration of Bacillus oligonitrophilus KU-1.

Treatment of cancer patients remains a serious medical problem and the development of alternative treatment strategies is therefore of great importance. In this connection, we developed a new bacterial-based, anticancer method. Ten cancer patients (three males, seven females) were involved in this study. Bacterial suspension of stationary phase Bacillus oligonitrophilus KU-1 was used as a remedy for peroral administration. In five patients, side effects (sicchasia, slight blood, and intracranial pressure gain) were detected, but all patients showed significant delay of lethal outcome without serious side effects. In conclusion, the suggested method was, in our opinion, a good alternative to conventional chemo- and radiotherapy techniques. In order to evaluate its efficiency for various tumors, a double-blind, placebo-controlled, multicenter study is needed

Explicit Character Formulae for Positive Energy UIRs of D=4 Conformal Supersymmetry

This paper continues the project of constructing the character formulae for the positive energy unitary irreducible representations of the N-extended D=4 conformal superalgebras su(2,2/N). In the first paper we gave the bare characters which represent the defining odd entries of the characters. Now we give the full explicit character formulae for N=1 and for several important examples for N=2 and N=4.Comment: 48 pages, TeX with Harvmac, overlap in preliminaries with arXiv:hep-th/0406154; some comments and references adde

Deformed Oscillator Algebras and Higher-Spin Gauge Interactions of Matter Fields in 2+1 Dimensions

We formulate a non-linear system of equations which describe higher-spin gauge interactions of massive matter fields in 2+1 dimensional space-time and explain some properties of the deformed oscillator algebra which underlies this formulation. In particular we show that the parameter of mass $M$ of matter fields is related to the deformation parameter in this algebra.Comment: LaTex, 12 pages, no figures; Invited talk at the International Seminar Supersymmetry and Quantum Field Theory dedicated to the memory of Dmitrij V. Volkov; Kharkov, January 1997; to appear in the proceeding

String Theoretic Bounds on Lorentz-Violating Warped Compactification

We consider warped compactifications that solve the 10 dimensional supergravity equations of motion at a point, stabilize the position of a D3-brane world, and admit a warp factor that violates Lorentz invariance along the brane. This gives a string embedding of ``asymmetrically warped'' models which we use to calculate stringy (\alpha') corrections to standard model dispersion relations, paying attention to the maximum speeds for different particles. We find, from the dispersion relations, limits on gravitational Lorentz violation in these models, improving on current limits on the speed of graviton propagation, including those derived from field theoretic loops. We comment on the viability of models that use asymmetric warping for self-tuning of the brane cosmological constant.Comment: 20pg, JHEP3; v2 additional references, slight change to intro; v3. added referenc

Antitumor features of Bacillus oligonitrophilus KU-1 strain

Chemotherapy and radiotherapy remain mostly palliative methods for metastatic cancer treatment. Limitations in efficacy and safety of established treatments continue to underline the need for improved treatments for malignancy. Results with some probiotics with antitumor activity have been promising. Here, we report that oral reception of Bacillus oligonitrophilus KU-1 resulted in the prolongation of lives in cancer patients with terminal prognosis and stabilization of cancer growth. The theoretical basis for the phenomena observed is discussed

Partition Functions for Higher-Spin theories in AdS

We calculate the one-loop partition function for a massless arbitrary-spin field on quotients of a general dimensional AdS background using the results of arXiv:1103.3627. We use these results to compute the one-loop partition function for a Vasiliev theory in AdS_5. An interesting form of the answer, suggestive of a vacuum character of an enhanced symmetry algebra is obtained. We also observe a close connection between the partition function for this Vasiliev theory and the d-dimensional MacMahon function.Comment: 14 pages, preprint number and acknowledgement adde

Characters of the Positive Energy UIRs of D=4 Conformal Supersymmetry

We give character formulae for the positive energy unitary irreducible representations of the N-extended D=4 conformal superalgebras su(2,2/N). Using these we also derive decompositions of long superfields as they descend to the unitarity threshold. These results are also applicable to irreps of the complex Lie superalgebras sl(4/N). Our derivations use results from the representation theory of su(2,2/N) developed already in the 80s.Comment: 81 pages, input files: harvmac, amssym.def, amssym.tex; corrected presentation on odd reflection