A comparison of DA white dwarf temperatures and gravities from Lyman and Balmer line studies

We present measurements of the effective temperatures and surface gravities for a sample of hot DA white dwarfs, using the Lyman line data available from the HUT, ORFEUS and FUSE far-UV space missions. Comparing the results with those from the standard Balmer line technique, we find that there is a general good overall agreement between the two methods. However, significant differences are found for a number of stars, but not always of a consistent nature in that sometimes the Balmer temperature exceeds that derived from the Lyman lines and in other instances is lower. We conclude that, with the latest model atmosphere calculations, these discrepancies probably do not arise from an inadequate theoretical treatment of the Lyman lines but rather from systematic effects in the observation and data reduction processes, which dominate the statistical errors in these spectra. If these systematic data reduction effects can be adequately controlled, the Lyman line temperature and gravity measurements are consistent with those obtained from the Balmer lines when allowance is made for reasonable observational uncertainties.Comment: Accepted for publication in Monthly Notices of the Royal Astronomical Society 14 pages, 13 figure

A serendipitous all sky survey for bright objects in the outer solar system

We use seven yearʼs worth of observations from the Catalina Sky Survey and the Siding Spring Survey covering most of the northern and southern hemisphere at galactic latitudes higher than 20° to search for serendipitously imaged moving objects in the outer solar system. These slowly moving objects would appear as stationary transients in these fast cadence asteroids surveys, so we develop methods to discover objects in the outer solar system using individual observations spaced by months, rather than spaced by hours, as is typically done. While we independently discover eight known bright objects in the outer solar system, the faintest having $V=19.8\pm 0.1,$ no new objects are discovered. We find that the survey is nearly 100% efficient at detecting objects beyond 25 AU for $V\lesssim 19.1$ ($V\lesssim 18.6$ in the southern hemisphere) and that the probability that there is one or more remaining outer solar system object of this brightness left to be discovered in the unsurveyed regions of the galactic plane is approximately 32%

Dynamic protein methylation in chromatin biology

Post-translational modification of chromatin is emerging as an increasingly important regulator of chromosomal processes. In particular, histone lysine and arginine methylation play important roles in regulating transcription, maintaining genomic integrity, and contributing to epigenetic memory. Recently, the use of new approaches to analyse histone methylation, the generation of genetic model systems, and the ability to interrogate genome wide histone modification profiles has aided in defining how histone methylation contributes to these processes. Here we focus on the recent advances in our understanding of the histone methylation system and examine how dynamic histone methylation contributes to normal cellular function in mammals

Factors Associated with Revision Surgery after Internal Fixation of Hip Fractures

Background: Femoral neck fractures are associated with high rates of revision surgery after management with internal fixation. Using data from the Fixation using Alternative Implants for the Treatment of Hip fractures (FAITH) trial evaluating methods of internal fixation in patients with femoral neck fractures, we investigated associations between baseline and surgical factors and the need for revision surgery to promote healing, relieve pain, treat infection or improve function over 24 months postsurgery. Additionally, we investigated factors associated with (1) hardware removal and (2) implant exchange from cancellous screws (CS) or sliding hip screw (SHS) to total hip arthroplasty, hemiarthroplasty, or another internal fixation device. Methods: We identified 15 potential factors a priori that may be associated with revision surgery, 7 with hardware removal, and 14 with implant exchange. We used multivariable Cox proportional hazards analyses in our investigation. Results: Factors associated with increased risk of revision surgery included: female sex, [hazard ratio (HR) 1.79, 95% confidence interval (CI) 1.25-2.50; P = 0.001], higher body mass index (fo

Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial

Background: Many patients with COVID-19 have been treated with plasma containing anti-SARS-CoV-2 antibodies. We aimed to evaluate the safety and efficacy of convalescent plasma therapy in patients admitted to hospital with COVID-19. Methods: This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]) is assessing several possible treatments in patients hospitalised with COVID-19 in the UK. The trial is underway at 177 NHS hospitals from across the UK. Eligible and consenting patients were randomly assigned (1:1) to receive either usual care alone (usual care group) or usual care plus high-titre convalescent plasma (convalescent plasma group). The primary outcome was 28-day mortality, analysed on an intention-to-treat basis. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936. Findings: Between May 28, 2020, and Jan 15, 2021, 11558 (71%) of 16287 patients enrolled in RECOVERY were eligible to receive convalescent plasma and were assigned to either the convalescent plasma group or the usual care group. There was no significant difference in 28-day mortality between the two groups: 1399 (24%) of 5795 patients in the convalescent plasma group and 1408 (24%) of 5763 patients in the usual care group died within 28 days (rate ratio 1·00, 95% CI 0·93–1·07; p=0·95). The 28-day mortality rate ratio was similar in all prespecified subgroups of patients, including in those patients without detectable SARS-CoV-2 antibodies at randomisation. Allocation to convalescent plasma had no significant effect on the proportion of patients discharged from hospital within 28 days (3832 [66%] patients in the convalescent plasma group vs 3822 [66%] patients in the usual care group; rate ratio 0·99, 95% CI 0·94–1·03; p=0·57). Among those not on invasive mechanical ventilation at randomisation, there was no significant difference in the proportion of patients meeting the composite endpoint of progression to invasive mechanical ventilation or death (1568 [29%] of 5493 patients in the convalescent plasma group vs 1568 [29%] of 5448 patients in the usual care group; rate ratio 0·99, 95% CI 0·93–1·05; p=0·79). Interpretation: In patients hospitalised with COVID-19, high-titre convalescent plasma did not improve survival or other prespecified clinical outcomes. Funding: UK Research and Innovation (Medical Research Council) and National Institute of Health Research