Bulletin of the Texas Archeological Society, Volume 71 (2000), Austin, Paper.

This annual bulletin of the Texas Archeological Society is a unique contribution specifically focused upon the history of Texas archaeology in a format that no others have done previously. The volume contains 150 pages, the majority of which consists of interviews (146 pages) conducted by the first State Archaeologist of Texas, Curtis Tunnell. In 1968 Tunnell conceived of the idea of obtaining personal interviews from individuals whom he considered his heroes for their pioneering efforts in Texas archeology. This volume entails the first publication of such information, but more will certainly follow. The remaining four pages comprise two different reviews of other publications important in their own right to those interested in Southern Plains archeology of Texas. These two reviews by Timothy K Pertulla and David T. Hughes, respectively, are of The Coronado Expedition to Tierra Nueva: The 1540·1542 Route Across the Southwest by Richard Flint and Shirley Cushing flint, and GaffCreek: Artifact Collection Strategy and Occupation Prehistory on the Southern High Plains, Texas County. Oklahoma. The section by Tunnell titled "In Their Own Words: Stories from Some Pioneer Texas Archeologists" contains numerous previously unpublished photographs of people, sites and artifacts referred to the texts

MDAN-21: A Bivalent Opioid Ligand Containing mu-Agonist and Delta-Antagonist Pharmacophores and Its Effects in Rhesus Monkeys

MDAN-21, , a bivalent opioid ligand containing a mu-opioid receptor agonist (derived from oxymorphone) linked to the delta-opioid receptor antagonist (related to naltrindole) by a spacer of 21 atoms, was reported to have potent analgesic properties in mice. Tolerance, physical dependence, and conditioned place preference were not evident in that species. The finding that bivalent ligands in this series, with spacers 19 atoms or greater, were devoid of tolerance and dependence led to the proposal that MDAN-21 targets heteromeric mu-delta-opioid receptors. The present study focused on its effects in nonhuman primates (Macaca mulatta), a species with a physiology and behavioral repertoire not unlike humans. With regard to opioids, this species usually better predicts clinical outcomes. MDAN-21 substituted for morphine in morphine-dependent monkeys in the remarkably low dose range 0.006–0.032 mg/kg, subcutaneously. Although MDAN-21 failed to produce reliable thermal analgesia in the dose range 0.0032–0.032 mg/kg, intramuscularly, it was active in the same dose range and by the same route of administration, in the capsaicin-induced thermal allodynia assay. The results suggest that MDAN-21 may be useful in the treatment of opioid dependence and allodynia. The data provide additional evidence that opioid withdrawal is associated with sensitized pain

Phases of Dense Quarks at Large N_c

In the limit of a large number of colors, N_c, we suggest that gauge theories can exhibit several distinct phases at nonzero temperature and quark density. Two are familiar: a cold, dilute phase of confined hadrons, where the pressure is ~ 1, and a hot phase of deconfined quarks and gluons, with pressure ~ N_c^2. When the quark chemical potential mu ~ 1, the deconfining transition temperature, T_d, is independent of mu. For T < T_d, as mu increases above the mass threshold, baryons quickly form a dense phase where the pressure is ~ N_c. As illustrated by a Skyrme crystal, chiral symmetry can be both spontaneously broken, and then restored, in the dense phase. While the pressure is ~ N_c, like that of (non-ideal) quarks, the dense phase is still confined, with interactions near the Fermi surface those of baryons, and not of quarks. Thus in the chirally symmetric region, baryons near the Fermi surface are parity doubled. We suggest possible implications for the phase diagram of QCD.Comment: 23 pages, 2 figures, uses entcs macro. Minor changes in wordin

Interweaving Chiral Spirals

We elaborate how to construct interweaving chiral spirals in (2+1) dimensions, defined as a superposition of chiral spirals oriented in different directions. We divide a two-dimensional Fermi sea into distinct wedges, characterized by the opening angle 2Theta and depth Q ~ pF, where pF is the Fermi momentum. In each wedge, the energy is lowered by forming a single chiral spiral. The optimal values for Theta and Q are chosen by balancing this gain in energy versus the cost of deforming the Fermi surface (which dominates at large Theta) and patch-patch interactions (dominant at small Theta). Using a non-local four-Fermi interaction model, we estimate the gain and cost in energy by expanding in terms of 1/Nc (where Nc is the number of colors), lqcd/Q, and Theta. Due to a form factor in our non-local model, at small 1/Nc the mass gap (chiral condensate) is large, and the interaction among quarks and the condensate local in momentum space. Consequently, interactions between different patches are localized near their boundaries, and it is simple to embed many chiral spirals. We identify the dominant and subdominant terms at high density and categorize formulate an expansion in terms of lqcd/Q or Theta. The kinetic term in the transverse directions is subdominant, so that techniques from (1+1)-dimensional systems can be utilized. To leading order in 1/Nc and lqcd/Q, the total gain in energy is ~ pF lqcd^2 with Theta ~ (lqcd/pF)^{3/5}. Since Theta decreases with increasing pF, there should be phase transitions associated with the change in the wedge number. We also argue the effects of subdominant terms at lower density where the large-Nc approximation is more reliable.Comment: 54 pages, 21 figures, published versio

Pediatric DXA: clinical applications

Normal bone mineral accrual requires adequate dietary intake of calcium, vitamin D and other nutrients; hepatic and renal activation of vitamin D; normal hormone levels (thyroid, parathyroid, reproductive and growth hormones); and neuromuscular functioning with sufficient stress upon the skeleton to induce bone deposition. The presence of genetic or acquired diseases and the therapies that are used to treat them can also impact bone health. Since the introduction of clinical DXA in pediatrics in the early 1990s, there has been considerable investigation into the causes of low bone mineral density (BMD) in children. Pediatricians have also become aware of the role adequate bone mass accrual in childhood has in preventing osteoporotic fractures in late adulthood. Additionally, the availability of medications to improve BMD has increased with the development of bisphosphonates. These factors have led to the increased utilization of DXA in pediatrics. This review summarizes much of the previous research regarding BMD in children and is meant to assist radiologists and clinicians with DXA utilization and interpretation

The James Webb Space Telescope Mission

Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least $4m$. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the $6.5m$ James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 years, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space Telescope Overview, 29 pages, 4 figure

The Science Performance of JWST as Characterized in Commissioning

This paper characterizes the actual science performance of the James Webb Space Telescope (JWST), as determined from the six month commissioning period. We summarize the performance of the spacecraft, telescope, science instruments, and ground system, with an emphasis on differences from pre-launch expectations. Commissioning has made clear that JWST is fully capable of achieving the discoveries for which it was built. Moreover, almost across the board, the science performance of JWST is better than expected; in most cases, JWST will go deeper faster than expected. The telescope and instrument suite have demonstrated the sensitivity, stability, image quality, and spectral range that are necessary to transform our understanding of the cosmos through observations spanning from near-earth asteroids to the most distant galaxies.Comment: 5th version as accepted to PASP; 31 pages, 18 figures; https://iopscience.iop.org/article/10.1088/1538-3873/acb29

Methyl methacrylate and respiratory sensitization: A Critical review

Methyl methacrylate (MMA) is a respiratory irritant and dermal sensitizer that has been associated with occupational asthma in a small number of case reports. Those reports have raised concern that it might be a respiratory sensitizer. To better understand that possibility, we reviewed the in silico, in chemico, in vitro, and in vivo toxicology literature, and also epidemiologic and occupational medicine reports related to the respiratory effects of MMA. Numerous in silico and in chemico studies indicate that MMA is unlikely to be a respiratory sensitizer. The few in vitro studies suggest that MMA has generally weak effects. In vivo studies have documented contact skin sensitization, nonspecific cytotoxicity, and weakly positive responses on local lymph node assay; guinea pig and mouse inhalation sensitization tests have not been performed. Cohort and cross-sectional worker studies reported irritation of eyes, nose, and upper respiratory tract associated with short-term peaks exposures, but little evidence for respiratory sensitization or asthma. Nineteen case reports described asthma, laryngitis, or hypersensitivity pneumonitis in MMA-exposed workers; however, exposures were either not well described or involved mixtures containing more reactive respiratory sensitizers and irritants.The weight of evidence, both experimental and observational, argues that MMA is not a respiratory sensitizer