Model validation for a noninvasive arterial stenosis detection problem

Copyright @ 2013 American Institute of Mathematical SciencesA current thrust in medical research is the development of a non-invasive method for detection, localization, and characterization of an arterial stenosis (a blockage or partial blockage in an artery). A method has been proposed to detect shear waves in the chest cavity which have been generated by disturbances in the blood flow resulting from a stenosis. In order to develop this methodology further, we use both one-dimensional pressure and shear wave experimental data from novel acoustic phantoms to validate corresponding viscoelastic mathematical models, which were developed in a concept paper [8] and refined herein. We estimate model parameters which give a good fit (in a sense to be precisely defined) to the experimental data, and use asymptotic error theory to provide confidence intervals for parameter estimates. Finally, since a robust error model is necessary for accurate parameter estimates and confidence analysis, we include a comparison of absolute and relative models for measurement error.The National Institute of Allergy and Infectious Diseases, the Air Force Office of Scientific Research, the Deopartment of Education and the Engineering and Physical Sciences Research Council (EPSRC)

Parameter identification in continuum models

Approximation techniques for use in numerical schemes for estimating spatially varying coefficients in continuum models such as those for Euler-Bernoulli beams are discussed. The techniques are based on quintic spline state approximations and cubic spline parameter approximations. Both theoretical and numerical results are presented

A differential calculus for multifunctions

Mathematical analysis of multifunction

Open String on Symmetric Product

We develop some basic properties of the open string on the symmetric product which is supposed to describe the open string field theory in discrete lightcone quantization (DLCQ). After preparing the consistency conditions of the twisted boundary conditions for Annulus/M\"obius/Klein Bottle amplitudes in generic non-abelian orbifold, we classify the most general solutions of the constraints when the discrete group is $S_N$. We calculate the corresponding orbifold amplitudes from two viewpoints -- from the boundary state formalism and from the trace over the open string Hilbert space. It is shown that the topology of the world sheet for the short string and that of the long string in general do not coincide. For example the annulus sector for the short string contains all the sectors (torus, annulus, Klein bottle, M\"obius strip) of the long strings. The boundary/cross-cap states of the short strings are classified into three categories in terms of the long string, the ordinary boundary and the cross-cap states, and the ``joint'' state which describes the connection of two short strings. We show that the sum of the all possible boundary conditions is equal to the exponential of the sum of the irreducible amplitude -- one body amplitude of long open (closed) strings. This is typical structure of DLCQ partition function. We examined that the tadpole cancellation condition in our language and derived the well-known gauge group $SO(2^{13})$.Comment: 56 pages, 11 figures, Late

Information Content in Data Sets for a Nucleated-Polymerization Model

We illustrate the use of tools (asymptotic theories of standard error quantification using appropriate statistical models, bootstrapping, model comparison techniques) in addition to sensitivity that may be employed to determine the information content in data sets. We do this in the context of recent models [23] for nucleated polymerization in proteins, about which very little is known regarding the underlying mechanisms; thus the methodology we develop here may be of great help to experimentalists

The synthesis of optimal controls for linear problems with retarded controls

Synthesis of optimal controls for linear systems with retarded control

Asymptotic Search for Ground States of SU(2) Matrix Theory

We introduce a complete set of gauge-invariant variables and a generalized Born-Oppenheimer formulation to search for normalizable zero-energy asymptotic solutions of the Schrodinger equation of SU(2) matrix theory. The asymptotic method gives only ground state candidates, which must be further tested for global stability. Our results include a set of such ground state candidates, including one state which is a singlet under spin(9).Comment: 51 page

Methods for the identification of material parameters in distributed models for flexible structures

Theoretical and numerical results are presented for inverse problems involving estimation of spatially varying parameters such as stiffness and damping in distributed models for elastic structures such as Euler-Bernoulli beams. An outline of algorithms used and a summary of computational experiences are presented

New Angle on the Strong CP and Chiral Symmetry Problems from a Rotating Mass Matrix

It is shown that when the mass matrix changes in orientation (rotates) in generation space for changing energy scale, then the masses of the lower generations are not given just by its eigenvalues. In particular, these masses need not be zero even when the eigenvalues are zero. In that case, the strong CP problem can be avoided by removing the unwanted $\theta$ term by a chiral transformation in no contradiction with the nonvanishing quark masses experimentally observed. Similarly, a rotating mass matrix may shed new light on the problem of chiral symmetry breaking. That the fermion mass matrix may so rotate with scale has been suggested before as a possible explanation for up-down fermion mixing and fermion mass hierarchy, giving results in good agreement with experiment.Comment: 14 page

Dynamic characteristics and processing of fillers in polyurethane elastomers for vibration damping applications

Polyurethane elastomers have the potential of being used to reduce vibrational noise in many engineering applications. The performance of the elastomer is directly related to matching the nature of the mechanical loss characteristics to the frequency and temperature dependence of the source of the vibration. Materials with a broad frequency response and good mechanical properties are desirable for situations were load bearing and isolation becomes an issue. Because automobile, and other related vehicles operate over a broad temperature range, it is desirable for the damping characteristics of the elastomer to ideally be independent of temperature and frequency. In practice, this is not possible and the creation of materials with a broad spectrum response is desirable. In this paper, the effects of various fillers on the breadth and temperature dependence of the vibration damping characteristics of a filled and crosslinked polyurethane elastomer are explored. The fillers studied are wollastonite, barium sulphate and talc. These materials have different shapes, sizes and surface chemistry and undergo different types of interaction with the matrix. The vibration damping characteristics were further varied by the use of a crosslinking agent. Data presented on the rheological characteristics indicate the strength of the filler-polyol interactions. Dielectric relaxation and dynamic mechanical thermal analysis demonstrate the way in which changes in the type of filler, concentration and amount of crosslinker lead to changes in the location and breadth of the energy dissipation process in these elastomers. The vibration damping characteristics of a selected material are presented to demonstrate the potential of these materials