176 research outputs found
A Critical Study of Rickets with Special Reference to its Treatment by "Artificial Sunlight" in a Scottish Industrial Area
Counting Exceptional Instantons
We show how to obtain the instanton partition function of N=2 SYM with
exceptional gauge group EFG using blow-up recursion relations derived by
Nakajima and Yoshioka. We compute the two instanton contribution and match it
with the recent proposal for the superconformal index of rank 2 SCFTs with E6,
E7 global symmetry.Comment: 16 pages, references adde
Integrated multi-level quality control for proteomic profiling studies using mass spectrometry
BACKGROUND: Proteomic profiling using mass spectrometry (MS) is one of the most promising methods for the analysis of complex biological samples such as urine, serum and tissue for biomarker discovery. Such experiments are often conducted using MALDI-TOF (matrix-assisted laser desorption/ionisation time-of-flight) and SELDI-TOF (surface-enhanced laser desorption/ionisation time-of-flight) MS. Using such profiling methods it is possible to identify changes in protein expression that differentiate disease states and individual proteins or patterns that may be useful as potential biomarkers. However, the incorporation of quality control (QC) processes that allow the identification of low quality spectra reliably and hence allow the removal of such data before further analysis is often overlooked. In this paper we describe rigorous methods for the assessment of quality of spectral data. These procedures are presented in a user-friendly, web-based program. The data obtained post-QC is then examined using variance components analysis to quantify the amount of variance due to some of the factors in the experimental design. RESULTS: Using data from a SELDI profiling study of serum from patients with different levels of renal function, we show how the algorithms described in this paper may be used to detect systematic variability within and between sample replicates, pooled samples and SELDI chips and spots. Manual inspection of those spectral data that were identified as being of poor quality confirmed the efficacy of the algorithms. Variance components analysis demonstrated the relatively small amount of technical variance attributable to day of profile generation and experimental array. CONCLUSION: Using the techniques described in this paper it is possible to reliably detect poor quality data within proteomic profiling experiments undertaken by MS. The removal of these spectra at the initial stages of the analysis substantially improves the confidence of putative biomarker identification and allows inter-experimental comparisons to be carried out with greater confidence
Effective Field Theories in the Large Limit
Various effective field theories in four dimensions are shown to have exact
non-trivial solutions in the limit as the number of fields of some type
becomes large. These include extended versions of the U(N) Gross-Neveu model,
the non-linear O(N) -model, and the model. Although these
models are not renormalizable in the usual sense, the infinite number of
coupling types allows a complete cancellation of infinities. These models
provide qualitative predictions of the form of scattering amplitudes for
arbitrary momenta, but because of the infinite number of free parameters, it is
possible to derive quantitative predictions only in the limit of small momenta.
For small momenta the large- limit provides only a modest simplification,
removing at most a finite number of diagrams to each order in momenta, except
near phase transitions, where it reduces the infinite number of diagrams that
contribute for low momenta to a finite number.Comment: 48 pages, no figures. This is a plain LaTeX file. No special macros
are neede
Does owning a pet protect older people against loneliness?
This article has been made available through the Brunel Open Access Publishing Fund.Pet ownership is thought to make a positive contribution to health, health behaviours and the general well-being of older people. More specifically pet ownership is often proposed as a solution to the problem of loneliness in later life and specific 'pet based' interventions have been developed to combat loneliness. However the evidence to support this relationship is slim and it is assumed that pet ownership is a protection against loneliness rather than a response to loneliness. The aim of this paper is to examine the association between pet ownership and loneliness by exploring if pet ownership is a response to, or protection against, loneliness using Waves 0-5 from the English Longitudinal Study of Ageing (ELSA)
Potent Anti-Tumor Effect Generated by a Novel Human Papillomavirus (HPV) Antagonist Peptide Reactivating the pRb/E2F Pathway
Human papillomavirus type 16 (HPV16) E7 is a viral oncoprotein believed to play a major role in cervical cancer. In this study, an antagonist peptide against HPV16E7 protein was first identified from screening the c7c phage display peptide library. The binding specificity and affinity of the selected peptide to HPV16E7 were tested by competitive enzyme-linked immunosorbent assay (ELISA). The antagonist peptide showed obvious anti-tumor efficacy both in cell lines and animal tumor models. Significant cell proliferation inhibition with high specificity was noted when HPV16-positive cells were treated with the peptide. This anti-tumor efficacy was resulted from overriding the activities of HPV16E7 and reactivating the pRb/E2F pathway, as shown by a series of experiments. Flow cytometry analysis revealed that the selected peptide induced G1 arrest in a dose-dependent manner. Competitive ELISA, pull down, and Co-IP experiments indicated that the selected peptide disrupted the interaction between HPV16E7 and pRb proteins both in vitro and in vivo. Luciferase reporter assay verified that transcription activities of E2F were suppressed by the peptide through restoration of pRb. RT-PCR and Western blot revealed that it reduced cyclins A, D1, and E1 expression, and led to HPV16E7 protein degradation, but pRb protein stabilization. The current study suggests that this specific peptide may serve as a potential therapeutic agent for HPV16-positive cervical cancer
Subject specific demands of teaching: Implications for out-of-field teachers
This chapter provides a framework for thinking about the subject-specific nature of teaching in terms of the
knowledge, modes of inquiry and discursive practices that delineate one subject from another in the
traditional school curriculum. The chapter will explore how these disciplinary traits are translated into
teaching as curriculum, knowledge and pedagogy, and how this subject-specificity of teaching is
juxtaposed against the more generic aspects of teaching. The chapter explores the idea that if a teacher’s
expertise can be situated within a field, then they can also be positioned out-of-field. Implications for
teaching out-of-field are discussed in terms of the subject-specific knowledge, processes and skills, and the
difficulties associated with teacher practice. English and Australian illustrations of teacher practices from
in-field and out-of-field situations are provided, in particular highlighting the demands of moving across
subject boundaries. Cross-fertilisation is especially evident when subjects are integrated, therefore, the
issues associated with integrated curriculum are discussed where the traditional subject boundaries are
being challenged as schools are reorganised to integrate subjects through, for example, STEM teaching, or
holistic curriculum designs
Immigration Rates in Fragmented Landscapes – Empirical Evidence for the Importance of Habitat Amount for Species Persistence
BACKGROUND: The total amount of native vegetation is an important property of fragmented landscapes and is known to exert a strong influence on population and metapopulation dynamics. As the relationship between habitat loss and local patch and gap characteristics is strongly non-linear, theoretical models predict that immigration rates should decrease dramatically at low levels of remaining native vegetation cover, leading to patch-area effects and the existence of species extinction thresholds across fragmented landscapes with different proportions of remaining native vegetation. Although empirical patterns of species distribution and richness give support to these models, direct measurements of immigration rates across fragmented landscapes are still lacking. METHODOLOGY/PRINCIPAL FINDINGS: Using the Brazilian Atlantic forest marsupial Gray Slender Mouse Opossum (Marmosops incanus) as a model species and estimating demographic parameters of populations in patches situated in three landscapes differing in the total amount of remaining forest, we tested the hypotheses that patch-area effects on population density are apparent only at intermediate levels of forest cover, and that immigration rates into forest patches are defined primarily by landscape context surrounding patches. As expected, we observed a positive patch-area effect on M. incanus density only within the landscape with intermediate forest cover. Density was independent of patch size in the most forested landscape and the species was absent from the most deforested landscape. Specifically, the mean estimated numbers of immigrants into small patches were lower in the landscape with intermediate forest cover compared to the most forested landscape. CONCLUSIONS/SIGNIFICANCE: Our results reveal the crucial importance of the total amount of remaining native vegetation for species persistence in fragmented landscapes, and specifically as to the role of variable immigration rates in providing the underlying mechanism that drives both patch-area effects and species extinction thresholds
Phase transitions in quantum chromodynamics
The current understanding of finite temperature phase transitions in QCD is
reviewed. A critical discussion of refined phase transition criteria in
numerical lattice simulations and of analytical tools going beyond the
mean-field level in effective continuum models for QCD is presented.
Theoretical predictions about the order of the transitions are compared with
possible experimental manifestations in heavy-ion collisions. Various places in
phenomenological descriptions are pointed out, where more reliable data for
QCD's equation of state would help in selecting the most realistic scenario
among those proposed. Unanswered questions are raised about the relevance of
calculations which assume thermodynamic equilibrium. Promising new approaches
to implement nonequilibrium aspects in the thermodynamics of heavy-ion
collisions are described.Comment: 156 pages, RevTex. Tables II,VIII,IX and Fig.s 1-38 are not included
as postscript files. I would like to ask the requestors to copy the missing
tables and figures from the corresponding journal-referenc
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