EXPEDITIOUS GREEN SYNTHESIS OF VERSATILE ORGANIC COMPOUNDS BY DIVERSE METHODS

Synthesis of organic compounds requires organic solvents and reagents to promote them. Very often, toxic solvents are used for this purpose. Many organic reactions require molar proportion of reactants and reagents to accomplish the goal. Some reactions require longer reaction times and produce products without control of stereochemistry. Therefore, development of facile and effective organic reactions under environmentally friendly conditions is necessary. In this perspective, several reactions are discussed that are performed by microwave-induced reactions, catalytic procedures, in the absence of any solvents, one-pot method and in water. Important reactions are chosen to investigate the feasibility of conducting these reactions under green chemistry conditions

Bismuth nitrate-induced microwave-assisted expeditious synthesis of vanillin from curcumin

Background: Curcumin and vanillin are the two useful compounds in food and medicine. Bismuth nitrate pentahydrate is an economical and ecofriendly reagent. Method: Bismuth nitrate pentahydrate impregnated montmorillonite KSF clay and curcumin were subjected to microwave irradiation. Results: Microwave-induced bismuth nitrate-promoted synthesis of vanillin from curcumin has been accomplished in good yield under solvent-free condition. Twenty-five different reaction conditions have been studied to optimize the process. Conclusion: The present procedure for the synthesis of vanillin may find useful application in the area of industrial process development

MICROWAVE-INDUCED PAAL-KNORR REACTION WITH AMMONIUM CHLORIDE: SYNTHESIS OF PYRROLES

An expeditious microwave-induced synthesis of pyrroles using commercially available 2,5- dimethoxytetrahydrofuran and primary amines in the presence of ammonium chloride has been achieved in excellent yield

SYTHESIS OF GLUCOSE PERACETATE VIA BISMUTH NITRATE-INDUCED REACTION

Simple synthesis peracetylated glucose has been achieved starting from glucose and acetic anhydride in the absence of solvent via bismuth nitrate-catalyzed reaction. This method does not need large excess of acetic anhydride

MICROWAVE-INDUCED BISMUTH NITRATE-CATALYZED EXPEDITIOUS ENAMINATION OF β-DICARBONYL COMPOUNDS UNDER SOLVENT-FREE CONDITIONS

Bismuth nitrate-catalyzed, automated microwave-assisted expeditious synthesis of β- enaminones and β-enaminoesters has been carried out in an efficient manner under solvent-free condition. The reaction is general for primary, secondary (cyclic, heterocyclic and acyclic), benzylic as well as aromatic amines

A Highly Efficient Bismuth Salts-Catalyzed Route for the Synthesis of Alpha-Aminophosphonates

A convenient synthesis of different types of α-amino phosphonates via one-pot solvent-free three component reactions of aldehydes, amines and phosphites catalyzed by bismuth salts has been investigated. Bismuth triflate is found to be the most effective catalyst for this reaction

Microwave-Assisted Ruthenium Trichloride-Catalyzed Synthesis of Pyrrole Fused With Indole System in Water

A simple and efficient microwave-induced ruthenium trichloride-catalyzed synthesis of pyrrole fused with indole system in water is developed by reacting commercially available isatin and 4-hydroxyproline

CARBON DIOXIDE-MEDIATED SYNTHESIS OF PYRROLES IN WATER

A novel carbon dioxide-mediated synthesis of diverse pyrroles using 2,5- dimethoxytetrahydrofuran and primary amines has been achieved in excellent yield. Despite the importance of pyrroles, no study has been performed using carbon dioxide as a reagent to accomplish Paal-Knorr reaction

CARBON DIOXIDE-MEDIATED PREPARATION OF PYRROLES IN WATER FOLLOWING PAAL KNORR METHOD

Carbon dioxide-mediated new reaction of 2,5-hexanedione and primary amino compounds in water-THF produced N-substituted pyrroles in excellent yield. This method for the preparation of pyrroles is novel, simple, and efficient

Highly Stereoselective B-Lactam Synthesis via the Staudinger Reaction Using Poly Aromatic Imines

Highly stereoselective synthesis of a few trans 3-phthalimido substituted B-lactams has been achieved following Staudinger reaction