17 research outputs found
Characterization of adult onset growth hormone deficiency syndrome in patients with hypothalamopituitary diseases: Asian Indian data
Background: Hardly any data is available on Adult onset growth hormone
deficiency (AOGHD) in Patients with hypothalamopituitary diseases in
India. Aims: To characterize Asian Indian AOGHD syndrome in
hypothalamopituitary diseases. Settings and Design: Cross-sectional
analysis of data from a tertiary care hospital. Materials and Methods:
Thirty patients with AOGHD were compared with 30 age-, sex-, body mass
index-matched controls with respect to endocrine evaluation,
biochemistry, body composition (BC), bone mineral density (BMD),
cardiovascular risk profile and quality of life (QoL). Statistical
Analysis Used: Comparisons were performed using two-tailed
Student′s test (SPSS Software version 10.0). Results: Most of the
patients had abnormal BC with central obesity [Truncal FM (%): males
{33.9±4.4 (patient) vs. 29.31±6.2 (control); P -0.027};
females {39.87±5.93 (patient) vs. 35.76±3.16 (control); P -
0.025}] and poor QoL. Patients aged over 45 years did not show low bone
mass or lipid abnormalities as compared to controls. Low BMD and
abnormal lipid profile {Triglycerides [mg/dl]:170.55±72.5
(patient) vs101.24±31.0 (control); P -0.038}; {very low density
lipoprotein cholesterol [mg/dl]: 33.54±14.9 (patient) vs.
20.25±6.18 (control); P - 0.05} was seen in female patients less
than 45 years of age. Conclusions: Male and female (more than 45 years)
AOGHD patients have increased cardiovascular risk factors and poor QoL
while BMD is unaffected. Females less than 45 years of age have the
major characteristics of AOGHD and would be the group to benefit
maximally with recombinant human Growth Hormone treatment, which is
similar to that in the western literature