Barley Crop Survey: A Report on the 1977 and 1978 Six-Row Malting Barley Crops

The 1977 and 1978 six-row malting barley crops grown in the prim growing areas of North Dakota, South Dakota and Minnesota were surveyed by the Department of Cereal Chemistry and Technology. The more than 800 samples collected each year were assayed for protein content, moisture, kernel plumpness and brightness and test weight. The 1978 crop was lower in protein content, moisture, plumpness and test weight and showed greater kernel brightness than the 1977 crop. It is estimated that about 65% of the total crop will fall below 13.5% protein and will be suitable for malting purposes

Bayesian uncertainty assessment of flood predictions in ungauged urban basins for conceptual rainfall-runoff models

Urbanization and the resulting land-use change strongly affect the water cycle and runoff-processes in watersheds. Unfortunately, small urban watersheds, which are most affected by urban sprawl, are mostly ungauged. This makes it intrinsically difficult to assess the consequences of urbanization. Most of all, it is unclear how to reliably assess the predictive uncertainty given the structural deficits of the applied models. In this study, we therefore investigate the uncertainty of flood predictions in ungauged urban basins from structurally uncertain rainfall-runoff models. To this end, we suggest a procedure to explicitly account for input uncertainty and model structure deficits using Bayesian statistics with a continuous-time autoregressive error model. In addition, we propose a concise procedure to derive prior parameter distributions from base data and successfully apply the methodology to an urban catchment in Warsaw, Poland. Based on our results, we are able to demonstrate that the autoregressive error model greatly helps to meet the statistical assumptions and to compute reliable prediction intervals. In our study, we found that predicted peak flows were up to 7 times higher than observations. This was reduced to 5 times with Bayesian updating, using only few discharge measurements. In addition, our analysis suggests that imprecise rainfall information and model structure deficits contribute mostly to the total prediction uncertainty. In the future, flood predictions in ungauged basins will become more important due to ongoing urbanization as well as anthropogenic and climatic changes. Thus, providing reliable measures of uncertainty is crucial to support decision making

Inhibition of poly(ADP-ribose) polymerase-1 attenuates the toxicity of carbon tetrachloride

Carbon tetrachloride (CCl4) is routinely used as a model compound for eliciting centrilobular hepatotoxicity. It can be bioactivated to the trichloromethyl radical, which causes extensive lipid peroxidation and ultimately cell death by necrosis. Overactivation of poly(ADP-ribose) polymerase-1 (PARP-1) can rapidly reduce the levels of (β-nicotinamide adenine dinucleotide and adenosine triphosphate and ultimately promote necrosis. The aim of this study was to determine whether inhibition of PARP-1 could decrease CCl4-induced hepatotoxicity, as measured by degree of poly(ADP-ribosyl)ation, serum levels of lactate dehydrogenase (LDH), lipid peroxidation,and oxidative DNA damage. For this purpose, male ICR mice were administered intraperitoneally a hepatotoxic dose of CCl4 with or without 6(5H)-phenanthridinone, a potent inhibitor of PARP-1. Animals treated with CCl4 exhibited extensive poly(ADP-ribosyl)ation in centrilobular hepatocytes, elevated serum levels of LDH, and increased lipid peroxidation. In contrast, animals treated concomitantly with CCl4 and 6(5H)-phenanthridinone showed significantly lower levels of poly(ADP-ribosyl) ation, serum LDH, and lipid peroxidation. No changes were observed in the levels of oxidative DNA damage regardless of treatment. These results demonstrated that the hepatotoxicity of CCl4is dependent on the overactivation of PARP-1 and that inhibition of this enzyme attenuates the hepatotoxicity of CCl4

Outcome of Endometrial Cancer Stage IIIA with Adnexa or Serosal Involvement Only

Objective. The aim of this study is to look at possible differences in outcome between serosa and adnexal involvement stage IIIA endometrial carcinoma. Methods. 67 patients with stage IIIA endometrial carcinoma were included, 46 with adnexal involvement and 21 with serosa. A central histopathological review was performed. Results. The 7-year locoregional failure rate was (LRFR) 2.2% for adnexal involvement and 16.0% for involvement of the serosa (P = .0522). The 7-year distant metastasis-free survival was 72.7% for adnexal involvement and 58.7% for serosa (P = .3994). The 7-year disease-specific survival (DSS) was 71.8% for patients with adnexal involvement and 75.4% for patients with serosa. Conclusion. Endometrial carcinoma stage IIIA with involvement of the adnexa or serosa showed to have a comparable disease-specific survival. Locoregional control was worse for serosa involvement compared to adnexa