Clinicopathological features of extranodal lymphomas: Kuwait experience

A total of 935 patients with extranodal non-Hodgkin lymphoma (NHL) diagnosed in the period between January 1985 and December 2000 in Kuwait Cancer Center, serving the whole population of Kuwait, were used to describe the clinicopathological and epidemiological features of extranodal lymphomas in Kuwait. Extranodal lymphomas accounted for 45% of all NHL observed during this time. All NHL cases from Kuwait Cancer registry were analyzed and pathologically reclassified using the latest WHO ( 2000) classification. The most common lymphoma observed was diffuse large B-cell lymphoma (58.60%) followed by Burkitt's lymphoma (BL) (3.80%). In the pediatric group, BL comprises more than two thirds of all patients (77.20%). The most common extranodal sites were stomach (19.70%) and skin (17.80%) in the adult group, large intestine (29.80%) and small intestine (19.30%) in the pediatric age group. The majority (73.40%) of adult extranodal lymphomas was in stage IE - IIE and had a very good prognosis. On the contrary, the majority of pediatric extranodal lymphomas were found to be in stage III and IV. Variations in treatment policies ( single agent or combined chemotherapy, radiotherapy, combined modality treatment) adopted and changed during the time period of 16 years of this retrospective study were documented. Copyright (C) 2004 S. Karger AG, Basel

Development of Non-Hodgkin's Lymphoma in a Child with Hyper-Ige Syndrome

This paper reports development of non-Hodgkin’s lymphoma in a 7'/2-year-old patient with hyper IgE syndrome. This rare primary immunodeficiency syndrome is characterized by markedly elevated serum IgE levels, chronic atypical dermatitis and serious recurrent infections. Laboratory features include exceptionally high levels of IgE, near normal levels of IgG, IgA, IgM, with pronounced eosinophilia

Role of microwaves in rapid processing of tissue for histopathology

Aim: The primary aim of the following study is to study the utility of microwave stimulated rapid processing of tissues for histopathology and the secondary aim is to compare the quality of the final product obtained after microwave stimulated rapid tissue processing with the conventional method. Materials and Methods: During the 3 years period of study, 150 cases were studied which were randomly selected from the tissues sent for histopathology. Tissues were processed by conventional method and by microwave assisted tissue processing. Results: Slides obtained by microwave and conventional tissue processing were statistically analyzed by using Chi-square test. The results obtained showed that the cellular and nuclear features of microwave processed tissues were comparable to conventionally processed tissue. Microwave assisted tissue processing reduced the total time for preparing tissue blocks to about an hour. Conclusion: Microwave stimulated processing provides an attractive alternative over traditional conventional processing

Histopathological Study of Primary Bone Tumours and Tumour-Like Lesions in a Medical Teaching Hospital

Objectives: Histopathological study of bone tumours to determine the spectrum of bone tumours at a Medical teaching Hospital and to correlate it with demographic features like age, sex of patients and anatomical site of tumours. Material and Methods: A retrospective and prospective study of all histopathologically diagnosed bone tumours over a period of 10 years was done. Patients were assessed by clinical examination, radiological investigations, histopathological examination and fine needle aspiration cytology (FNAC) whenever available. Results: A total of eighty-two cases of primary bone tumours were recorded, of which benign tumours were the most common 62 cases (75.61%) followed by malignant tumours with 13 cases (15.85%) and 7 cases (8.54%) of tumour-like lesions. FNAC diagnosis was available in 26 cases (31.71 %) with 68.96 % benign tumours, 17.24% malignant and 3.45% were tumour– like lesions. The concordance and discordance rate of histopathological diagnosis was 76.93% and 23.07 % respectively. On histopathological diagnosis, the most common benign tumour was osteochondroma 34.15% followed by Giant cell tumour 19.51%. Osteosarcoma was commonest malignant tumour 8.54%. Maximum number of bone tumours occurred in 11-20 years of age and the male to female ratio was 1.2:1. Conclusions: Bone tumours occurredpredominantly in the second decade of life with a male preponderance. Osteochondroma was the most common benign tumour followed by Giant cell tumour and Osteosarcoma was the most common malignant bone tumour

Role of direct immunofluorescence in the diagnosis of glomerulonephritis

Background: Immunofluorescence microscopy is a vital tool for the diagnosis of glomerular diseases. This study was carried out to study patterns of glomerulonephritis (GN) and to record the sensitivity of direct immunofluorescence (DIF) in renal lesions. The DIF findings were correlated with clinical and histopathology findings and discrepancies were analyzed. Materials and Methods: The cross-sectional analytical study was conducted during the period July 2011 to July 2013 at a tertiary care Hospital, Department of Pathology. A total of 75 renal biopsies were received for routine and immunofluorescence studies in which histopathology and clinical data were reviewed and analyzed. Results: The sensitivity of DIF was 87.9% and specificity was 70.5%. The maximum number of cases were seen in the age group 41-50 years. The pattern of GN by DIF was minimal change disease (MCD) in 24%, IgA nephropathy in 13%, focal segmental glomerulosclerosis in 9% and membranoproliferative glomerulonephritis in 8% of the cases. Twelve histopathologically proven cases of GN were negative on DIF. One case of MCD on histopathology was diagnosed as IgM nephropathy based on DIF. Conclusion: Direct immunofluorescence forms an important diagnostic tool in reaching the exact diagnosis in various types of GN presenting with overlapping clinical and histomorphological features