Criminal Law Revision in Delaware and Hawaii

Criminal law revision has not been limited to the largest states, which have greater resources and legal facilities, but has also occurred in Delaware and Hawaii, states which have relatively small numbers of legal practitioners, no local school of law, and relatively small populations. In both states, criminal law revision efforts were quite similar, in that an early decision was made to rely heavily on published revised codes of other jurisdictions and on the Model Penal Code, rather than undertaking an extensive initial study and preparing a unique code. The following article will compare the criminal law revision projects in both states, with particular attention to the organization used in each jurisdiction to effectuate reform and the sources used for particular provisions

Criminal Law Revision in Delaware and Hawaii

Criminal law revision has not been limited to the largest states, which have greater resources and legal facilities, but has also occurred in Delaware and Hawaii, states which have relatively small numbers of legal practitioners, no local school of law, and relatively small populations. In both states, criminal law revision efforts were quite similar, in that an early decision was made to rely heavily on published revised codes of other jurisdictions and on the Model Penal Code, rather than undertaking an extensive initial study and preparing a unique code. The following article will compare the criminal law revision projects in both states, with particular attention to the organization used in each jurisdiction to effectuate reform and the sources used for particular provisions

Characteristics of the National Applicant Pool for Clinical Informatics Fellowships (2018-2020).

In a prior survey, we found that applicants for 2017 ACGME-accredited clinical informatics fellowship positions were only 24% female and only 3% were members of underrepresented minorities (URM, consisting of American Indian or Alaska Native, Black or African American, Hispanic, Latino, or Spanish Origin, or Native Hawaiian or Other Pacific Islander). Since 2018, applications for clinical informatics fellowships have been accepted through the AAMC's Electronic Residency Application Service (ERAS). We analyzed national data from ERAS on applicants to clinical informatics fellowship programs for 2018 to 2020 positions. We also obtained applicants' subsequent success in starting clinical informatics fellowship training from the AAMC's GME Track survey. Over these 3 years, we found that the fellowship applicant pool grew from 63 to 74 (17%) and the number of positions offered grew from 34 to 41 (17%). The proportion of women applicants grew to 34% by 2020 and the proportion of underrepresented minorities grew to 12% by 2020. By comparison, medical students 7 years earlier (2013) were 47% female (P=.01) and 16% URM (P>.20), and applicants to many other subspecialties were similar. Applicants' sex and URM membership were not associated with success in starting fellowship training. We conclude that the underrepresentation of women and URM members in clinical informatics fellowships has improved but not resolved. Urgent efforts are needed to increase the both the numbers and the diversity of clinical informatics applicants by promoting the field among medical students and residents, particularly among women and URM members

Study of the Effects of Single Concept Loop Films upon Laboratory Techniques When Used for Pre-laboratory Instruction in the Introductory Organic Chemistry Laboratory

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Accelerated creep(ing): A 'buy & forget' mentality for Chinese homes

Accelerated creep(ing): A 'buy & forget' mentality for Chinese home

Maintenance of Constitutive I B Kinase Activity by Glycogen Synthase Kinase-3 / in Pancreatic Cancer

Constitutive NF-κB activation is among the many deregulated signaling pathways that are proposed to drive pancreatic cancer cell growth and survival. Recent reports suggest that glycogen synthase kinase-3β (GSK-3β) plays a key role in maintaining basal NF-κB target gene expression and cell survival in pancreatic cancer cell lines. However, the mechanism by which GSK-3β facilitates constitutive NF-κB signaling in pancreatic cancer remains unclear. In this report, we analyze the contributions of both GSK-3 isoforms (GSK-3α, GSK-3β) in regulating NF-κB activation and cell proliferation in pancreatic cancer cell lines (Panc-1 and MiaPaCa-2). We demonstrate that GSK-3 isoforms are differentially required to maintain basal NF-κB DNA binding activity, transcriptional activity, and cell proliferation in Panc-1 and MiaPaCa-2 cells. Our data also indicate that IKK subunits are not equally required to regulate pancreatic cancer-associated NF-κB activity and cell growth. Importantly, we provide the first evidence that GSK-3 maintains constitutive NF-κB signaling in pancreatic cancer by regulating IKK activity. These data provide new insight into GSK-3-dependent NF-κB regulation, and further establishes GSK-3 and IKK as potential therapeutic targets for pancreatic cancer

Transplacental induction of membranous nephropathy in a neonate

We report a case of renal failure in a newborn infant due to membranous glomerulonephritis. The patient was anuric in the first 3 weeks of life, after which renal function recovered. The serum of the mother contained IgG antibodies which reacted with tubular brush borders and glomeruli of adult and fetal human kidneys. Reactivity with renal epithelium from human kidneys was detected. We suggest that a transplacental, passive Heymann nephritis-like mechanism was the pathogenesis of the neonate's symptoms, although the antigen(s) involved was shown not to be gp 330 or any of the renal antigens known to be involved in experimental nephropathies

Factors affecting the transfer of learning to the workplace

Training aims to respond to the needs of development of individuals and organizations (Grohmann & Kauffeld, 2013). Based on Holton model, we carried out a study seeking to identify and understand the factors involved in the process of learning transfer to the workplace from two different training actions on the design and skills. The study took place at a Portuguese organization and involved 98 participants. Former students were interviewed with the purpose to explore the factors that facilitated or hindered the learning transfer, and the Inventory of the Portuguese version of the Learning Transfer System (Holton, Bates, Seyler & Carvalho, 1997; Velada & Caetano, 2009) was applied. The results suggest that the Holton model (2005) shows that the trainees have identified important issues for learning transfer and that there are differences in relation to the transfer factor pursuant to the type of training.info:eu-repo/semantics/publishedVersio

Chromosomal localization of the genes encoding the p50/p105 subunits of NF-κB (NFKB2) and the IκB/MAD-3 (NFKBI) inhibitor of NF-κB to 4q24 and 14q13, respectively

The regulation of expression of a variety of genes involved in immune function, inflammation, and cellular growth control, as well as control of expression of certain viruses such as the human immunodeficiency virus (HIV), is dependent on the transcription factor NF-κB. In many cells, NF-κB is found in the cytoplasm where it is associated with an inhibitor protein known as IκB. Recently the genes encoding the p50 and p65 subunits of NF-κB, as well as one form of IκB/MAD-3 (NFKBI), have been cloned. As part of our goal to determine the chromosomal organization of members of the REL/NFKB family, as well as their inhibitors, we localized the NFKBp50/p105 (NFKB2) and IκB/MAD-3 (NFKBI) genes to human chromosome bands 4q24 and 14q13, respectively