The significance of c.690G>T polymorphism (rs34529039) and expression of the CEBPA gene in ovarian cancer outcome

The CEBPA gene is known to be mutated or abnormally expressed in several cancers. This is the first study assessing the clinical impact of CEBPA gene status and expression on the ovarian cancer outcome. The CEBPA gene sequence was analyzed in 118 ovarian cancer patients (44 platinum/cyclophosphamide (PC)-treated and 74 taxane/platinum (TP)-treated), both in tumors and blood samples, and in blood from 236 healthy women, using PCR-Sanger sequencing and Real-Time quantitative PCR (qPCR)-based genotyping methods, respectively. The CEBPA mRNA level was examined with Reverse Transcription quantitative PCR (RT-qPCR). The results were correlated to different clinicopathological parameters. Thirty of 118 (25.4%) tumors harbored the CEBPA synonymous c.690G>T polymorphism (rs34529039), that we showed to be related to up-regulation of CEBPA mRNA levels (p=0.0059). The presence of the polymorphism was significantly associated with poor prognosis (p=0.005) and poor response to the PC chemotherapy regimen (p=0.024). In accordance, elevated CEBPA mRNA levels negatively affected patient survival (pT, p.(Thr230Thr) (rs34529039) polymorphism of the CEBPA gene, together with up-regulation of its mRNA expression, are negative factors worsening ovarian cancer outcome. Their adverse clinical effect depends on a therapeutic regimen used, which might make them potential prognostic and predictive biomarkers for response to DNA-damaging chemotherapy

Systems Genome:Coordinated Gene Activity Networks, Recurring Coordination Modules, and Genome Homeostasis in Developing Neurons

Simple Summary: A synchronized global genome is a flexible, homeostatic system that underwrites ontogenic development and deprograming in disease. Abstract: As human progenitor cells differentiate into neurons, the activities of many genes change; these changes are maintained within a narrow range, referred to as genome homeostasis. This process, which alters the synchronization of the entire expressed genome, is distorted in neurodevelopmental diseases such as schizophrenia. The coordinated gene activity networks formed by altering sets of genes comprise recurring coordination modules, governed by the entropy-controlling action of nuclear FGFR1, known to be associated with DNA topology. These modules can be modeled as energy-transferring circuits, revealing that genome homeostasis is maintained by reducing oscillations (noise) in gene activity while allowing gene activity changes to be transmitted across networks; this occurs more readily in neuronal committed cells than in neural progenitors. These findings advance a model of an “entangled” global genome acting as a flexible, coordinated homeostatic system that responds to developmental signals, is governed by nuclear FGFR1, and is reprogrammed in disease

"The Bayesian Objection" - Ch 4 of Seemings and Epistemic Justification

In this chapter I analyse an objection to phenomenal conservatism to the effect that phenomenal conservatism is unacceptable because it is incompatible with Bayesianism. I consider a few responses to it and dismiss them as misled or problematic. Then, I argue that this objection doesn’t go through because it rests on an implausible formalization of the notion of seeming-based justification. In the final part of the chapter, I investigate how seeming-based justification and justification based on one’s reflective belief that one has a seeming interact with one another

Conceivability and possibility : some dilemmas for Humeans

This research is published within the Project ‘The Logic of Conceivability’, funded by the European Research Council (ERC CoG), Grant Number 681404.The Humean view that conceivability entails possibility can be criticized via input from cognitive psychology. A mainstream view here has it that there are two candidate codings for mental representations (one of them being, according to some, reducible to the other): the linguistic and the pictorial, the difference between the two consisting in the degree of arbitrariness of the representation relation. If the conceivability of P at issue for Humeans involves the having of a linguistic mental representation, then it is easy to show that we can conceive the impossible, for impossibilities can be represented by meaningful bits of language. If the conceivability of P amounts to the pictorial imaginability of a situation verifying P, then the question is whether the imagination at issue works purely qualitatively, that is, only by phenomenological resemblance with the imagined scenario. If so, the range of situations imaginable in this way is too limited to have a significant role in modal epistemology. If not, imagination will involve some arbitrary labeling component, which turns out to be sufficient for imagining the impossible. And if the relevant imagination is neither linguistic nor pictorial, Humeans will appear to resort to some representational magic, until they come up with a theory of a ‘third code’ for mental representations.Publisher PDFPeer reviewe

Analysis of power losses during turning on pair of power transistors MOS-FET and IGBT working in resonant inverter

W niniejszym artykule przedstawiono topologię rezonansowego układu przekształtnikowego służącego do generacji bardzo krótkich impulsów o wysokiej mocy. Omówiono celowość równoległego łączenia ze sobą dwóch typów tranzystorów: MOS-FET i IGBT, pracujących jako klucze w przekształtnikach rezonansowych typu Kicker Power Supply (KPS). Przedstawiono wpływ niejednoczesności załączenia tranzystorów na sprawność przetwornicy oraz na straty mocy na tych tranzystorach. Zwrócono również uwagę na opóźnienia czasu załączania wprowadzane przez sterowniki tranzystorów mocy. Omówiono także wpływ wartości rezystancji łączącej sterownik z tranzystorem mocy na sprawność przetwornicy rezonansowej.Paper presents topology of resonant inverter which is used to generate very short, high-power pulses. Advisability of parallel connecting two kinds of transistors: MOS-FET and IGBT, working as keys in resonant inverters in Kicker Power Supply (KPS) were discussed. Influence of unsimultaneity of turning on transistors to efficiency of inverter and the power losses on these transistors was presented. Paper discussed also the delays added by the drivers of power transistors and the influence of value of resistance connecting driver with power transistor on efficiency of resonant inverter

The binary nature of relationships in two David Mamet duologues : A life in the theatre and Oleanna

Although David Mamet is one of the most frequently studied of the postmodern American playwrights, scholarly criticism has neglected to examine the dynamic that is unique to his two-person plays, or duologues. This study explores various aspects of that duologic dynamic, concentrating on two of Mamet's two-person plays, A Life in the Theatre and Oleanna. The relationships in both plays are sustained by the characters' desire for power. As is typical of a Mametian play, power is obtained through language and dialogue. The fact that there are two characters in each of the plays serves to intensify the conflict and to remind the audience of the binary nature inherent in drama.Thesis (M.A.)Department of Englis

The binary nature of relationships in two David Mamet duologues : A life in the theatre and Oleanna

Although David Mamet is one of the most frequently studied of the postmodern American playwrights, scholarly criticism has neglected to examine the dynamic that is unique to his two-person plays, or duologues. This study explores various aspects of that duologic dynamic, concentrating on two of Mamet's two-person plays, A Life in the Theatre and Oleanna. The relationships in both plays are sustained by the characters' desire for power. As is typical of a Mametian play, power is obtained through language and dialogue. The fact that there are two characters in each of the plays serves to intensify the conflict and to remind the audience of the binary nature inherent in drama.Department of EnglishThesis (M.A.

Outline history of electrification towns of Western Pomerania in the late XIX and early XX century

The article presents the first phase of electrification of the towns of Western Pomerania (according to the state for 1905.). Presented a local power plants with pistons steam engines and direct current generators with low voltage 110V, 2- or 3-wires. As the end of the first electrification period was the introduction of a alternating current 3-phase system.W artykule przedstawiono pierwszy etap elektryfikacji miast Pomorza Zachodniego (według stanu do 1905r.). Zaprezentowano lokalne elektrownie z maszynami parowymi tłokowymi i generatorami prądu stałego, niskiego napięcia 110V, 2- lub 3-przewodowymi. Cenzurą okresu pierwszej elektryfikacji było wprowadzenie systemu prądu przemiennego 3-fazowego