A comparative study of local cortisone administrations to that of systemic in buccal mucosa carcinogenesis

Thesis (M.Sc.D.)--Boston University School of Graduate Dentistry, 1972. (Oral surgery)Bibliography included.Sixty male golden Syrian hamsters (Lakeview Hamster Colony, Newfield, New Jersey), three months of age, were divided into five equal experimental groups and fed a standard laboratory diet. The animals of Group I (Control) received triweekly application of heavy mineral oil (USP) into the right buccal pouch with a No. 4 camel's hair brush for 16 weeks. The animals of Groups II, III, IV, and V received triweekly topical application of 7-12-dimethylbenzanthracene (DMBA) at a concentration of 0.5% w/v in heavy mineral oil (USP), according to the technic of Salley (J. Dent. Res., 33:253-262, 1954). In this manner about 0.2 ml. of solution was deposited in the pouch at each painting, containing 1 mg. of DMBA. Animals in Group III, in addition to the application of DMBA, received a triweekly S.C. , injection into the groin of 2.5 mg. of cortisone acetate (Premo Pharmaceutical Laboratory, Inc., Hackensack, New Jersey). [TRUNCATED