Condición de la producción vocal de los profesores de Instituciones Educativas Públicas de Lima Metropolitana

La presente tesis tuvo como objetivo describir las características de la producción vocal de los profesores de Instituciones Educativas Públicas de Lima Metropolitana. El tipo y diseño de la presente investigación fue básica no experimental, ya que se analizó las características de la producción vocal de los profesores. Constó de una muestra de 400 docentes de educación inicial, primaria, secundaria y superior de Instituciones Educativas Públicas de Lima Metropolitana, la cual se obtuvo por medio de un muestreo no probabilístico. Para el análisis de la producción vocal, se utilizó la técnica de la encuesta, cuyo instrumento es el siguiente, “Condición de la producción vocal del profesor” los autores son Ghirardi ACA, Ferreira LP, Giannini SPP, Latorre MRDO, conformado por 47 preguntas de opción múltiple y con respuestas cortas. En referencia a las conclusiones que hallamos, es que el 32% dicta hasta 10 horas por semana. Asimismo, el 54% señaló nunca haber recibido orientación sobre el cuidado de su voz. Por otro lado, el 93% indicó haberse ausentado de su centro laboral de 1 a 5 días por problemas de voz. Por último, los síntomas más frecuentes de problemas de voz que presenta un docente son los siguientes: carraspera, ronquera y tos seca.The objective of the following thesis was to describe the characteristics of the vocal output of the teachers of Public Educational Institutions of Metropolitan Lima. The type and design of this research was basic not experimental, since it analyzed the characteristics of the teachers’ vocal production were analyzed. It consisted of a sample of 400 teachers in the levels of initial, primary, secondary and higher education of Public Educational Institutions of Metropolitan Lima, which was obtained by a non-probability sampling. For the analysis of vocal production, we used the survey technique, whose instrument is the following, "Condition of the teacher’s vocal production" the authors are Ghirardi ACA, Ferreira LP, Giannini SPP, Latorre MRDO, formed by 47 multiple choice questions and short answers. In reference to the conclusions, we registered that up to 32% of the teachers dictate up to 10 hours per week. In addition, 54% said they had never received guidance on how to care for their voice. On the other hand, 93% indicated that they had been absent from their workplace for 1 to 5 days due to voice problems. Finally, the most common symptoms of voice problems in a teacher are the following: throat thing, hoarseness, and dry cough

Energetics of formation and stability in high pressure steam of barium lanthanide cobaltite double perovskites

[EN] This study concerns energetics of formation and the stability in high water partial pressure of BaLnCo(2)O(6-delta), (Ln = La, Pr, Nd, and Gd) (BLnC) and BaGd1-xLaxCo2O6-delta, where x = 0.2, 0.5, and 0.7 (BGLC) double perovskite cobaltites. Those materials are extensively studied due to their potential applications as a positrode in electrochemical devices. Therefore, their stability under such conditions is a key issue. All investigated materials are thermodynamically stable relative to binary oxides and exhibit strongly exothermic enthalpies of formation. Moreover, BaGd0.3La0.7Co2O6-delta and BaGd0.8La0.2Co2O6-delta remain the main perovskite structure up to 3 bars of water vapor at 400 degrees C. At higher steam pressure, reaching 10 bar at 300 degrees C, the partial decomposition to constituent oxides and hydroxides was observed. The BGLC compounds exhibit higher negative formation enthalpies in comparison to single-Ln compositions, which does not translate into higher chemical stability under high steam pressures since the BLnC series retained the main perovskite structure at higher temperatures as well as in higher water vapor pressures.The research has been supported by the National Science Centre Poland (2016/22/Z/ST5/00691), the Spanish Ministry of Science and Innovation (PCIN-2017-125, RTI2018-102161, and IJCI-2017-34110), and the Research Council of Norway (grant no. 272797 "GoPHy MiCO") through the M-ERA.NET Joint Call 2016. We also acknowledge Solaris National Radiation Centre Poland for access to the PIRX (XAS/PEEM) beamline time (proposal no 201036). Dr Chiu C. Tang at beamline I11 at Diamond Light Source, Didcot, UK is gratefully acknowledged SR-PXD measurements. The calorimetry at Arizona State University received financial support from the U.S. Department of Energy, Office of Basic Energy Sciences, grant DE-SC0021987.Mielewczyk-Gryn, A.; Yang, S.; Balaguer Ramirez, M.; Strandbakke, R.; Sorby, MH.; Szpunar, I.; Witkowska, A.... (2023). Energetics of formation and stability in high pressure steam of barium lanthanide cobaltite double perovskites. Dalton Transactions. 52(17):5771-5779. https://doi.org/10.1039/d2dt03989c57715779521

Amphiphilic Polymeric Nanoparticles Modified with a Protease-Resistant Peptide Shuttle for the Delivery of SN-38 in Diffuse Intrinsic Pontine Glioma

Diffuse intrinsic pontine glioma (DIPG) is a chemo-resistant, incurable pediatric tumor of the central nervous system (CNS). The blood–brain barrier (BBB) remains intact in the course of the disease, preventing drugs from entering the brain and resulting in therapeutic failure. The topoisomerase I inhibitor SN-38 shows strong anticancer activity in a patient-derived DIPG cell line in vitro, though a low CNS bioavailability and anti-DIPG efficacy in vivo. In this work, we produced SN-38-loaded polymeric nanoparticles of an amphiphilic chitosan (CS)-g-poly(methyl methacrylate)-poly(acrylic acid) copolymer that were surface-modified with a peptide shuttle that improves transport across the BBB. Drug-loaded nanoparticles displayed a size of ∼200 nm (intensity distribution) and a ζ-potential of +16 mV. The cytocompatibility and endocytosis assayed in DIPG cells (both attached and in suspension) indicated that the nanoparticles are compatible and mainly internalized by clathrin-mediated endocytosis and that the anticancer activity of SN-38 is preserved after nanoencapsulation. In addition, a tandem permeability/anticancer activity study utilizing a coculture model of BBB endothelial cells and DIPG cell spheroids demonstrated that the modified nanoparticles cross a BBB endothelial cell monolayer to a higher extent than the unmodified counterparts and are taken up by DIPG cells. After 72 h of exposure, both SN-38-loaded nanoparticles killed ∼84-88% of the DIPG cells in suspension, indicating that they reach a concentration above the inhibitory concentration 50 of the drug. Finally, the brain accumulation of the drug-loaded nanoparticles upon intravenous injection to Hsd:ICR mice was preliminarily characterized by light sheet fluorescence microscopy. As opposed to unmodified SN-38-loaded nanoparticles, the modified counterparts bind the brain blood vessels and accumulate in the cerebral parenchyma to a large extent. These results confirm the potential of this nanotechnology platform to deliver anticancer agents to the brain in DIPG and other brain tumors with fully conserved BBB.This work was funded by the Ministry of Health of Israel andthe 7th Framework Programme-European Commission (Proj-ect EuroNanoMed II Cure2DIPG), the Israel ScienceFoundation (Grant#269/15), and the Generalitat deCatalunya (XRB and 2017SGR0998). A.M.C. was supportedby grants from ISCIII-FEDER (CP13/00189 and CPII18/00009). IRB Barcelona is the recipient of a Severo OchoaAward of Excellence from MINECO (Government of Spain)and is supported by the CERCA Programme of the CatalanGovernment. The partial support of the Russell BerrieNanotechnology Institute (RBNI, Technion-Israel Instituteof Technology) is acknowledged. We thank Efrat Barak andNitzan Dahan (Life Sciences and Engineering InfrastructureCenter, Lorry I. Lokey Center, Technion-Israel Institute ofTechnology) for technical assistance with CLSM, LSFM, andimagingflow cytometryPeer reviewe

Risk of cancer in family members of patients with lynch-like syndrome

Lynch syndrome (LS) is a common cause of hereditary colorectal cancer (CRC). Some CRC patients develop mismatch repair deficiency without germline pathogenic mutation, known as Lynch-like syndrome (LLS). We compared the risk of CRC in first-degree relatives (FDRs) in LLS and LS patients. LLS was diagnosed when tumors showed immunohistochemical loss of MSH2, MSH6, and PMS2; or loss of MLH1 with BRAF wild type; and/or no MLH1 methylation and absence of pathogenic mutation in these genes. CRC and other LS-related neoplasms were followed in patients diagnosed with LS and LLS and among their FDRs. Standardized incidence ratios (SIRs) were calculated for CRC and other neoplasms associated with LS among FDRs of LS and LLS patients. In total, 205 LS (1205 FDRs) and 131 LLS families (698 FDRs) had complete pedigrees. FDRs of patients with LLS had a high incidence of CRC (SIR, 2.08; 95% confidence interval (CI), 1.56-2.71), which was significantly lower than that in FDRs of patients with LS (SIR, 4.25; 95% CI, 3.67-4.90; p < 0.001). The risk of developing other neoplasms associated with LS also increased among FDR of LLS patients (SIR, 2.04; 95% CI, 1.44-2.80) but was lower than that among FDR of patients with LS (SIR, 5.01, 95% CI, 4.26-5.84; p < 0.001). FDRs with LLS have an increased risk of developing CRC as well as LS-related neoplasms, although this risk is lower than that of families with LS. Thus, their management should take into account this increased risk

Clinical and Pathological Characterization of Lynch-Like Syndrome

Background & aims: Lynch syndrome is characterized by DNA mismatch repair (MMR) deficiency. Some patients with suspected Lynch syndrome have DNA MMR deficiencies but no detectable mutations in genes that encode MMR proteins-this is called Lynch-like syndrome (LLS). There is no consensus on management of patients with LLS. We collected data from a large series of patients with LLS to identify clinical and pathology features. Methods: We collected data from a nationwide-registry of patients with colorectal cancer (CRC) in Spain. We identified patients whose colorectal tumors had loss of MSH2, MSH6, PMS2, or MLH1 (based on immunohistochemistry), without the mutation encoding V600E in BRAF (detected by real-time PCR), and/or no methylation at MLH1 (determined by methylation-specific multiplex ligation-dependent probe amplification), and no pathogenic mutations in MMR genes, BRAF, or EPCAM (determined by DNA sequencing). These patients were considered to have LLS. We collected data on demographic, clinical, and pathology features and family history of neoplasms. The χ2 test was used to analyze the association between qualitative variables, followed by the Fisher exact test and the Student t test or the Mann-Whitney test for quantitative variables. Results: We identified 160 patients with LLS; their mean age at diagnosis of CRC was 55 years and 66 patients were female (41%). The Amsterdam I and II criteria for Lynch syndrome were fulfilled by 11% of cases and the revised Bethesda guideline criteria by 65% of cases. Of the patients with LLS, 24% were identified in universal screening. There were no proportional differences in sex, indication for colonoscopy, immunohistochemistry, pathology findings, or personal history of CRC or other Lynch syndrome-related tumors between patients who met the Amsterdam and/or Bethesda criteria for Lynch syndrome and patients identified in universal screening for Lynch syndrome, without a family history of CRC. Conclusions: Patients with LLS have homogeneous clinical, demographic, and pathology characteristics, regardless of family history of CRC

25th annual computational neuroscience meeting: CNS-2016

The same neuron may play different functional roles in the neural circuits to which it belongs. For example, neurons in the Tritonia pedal ganglia may participate in variable phases of the swim motor rhythms [1]. While such neuronal functional variability is likely to play a major role the delivery of the functionality of neural systems, it is difficult to study it in most nervous systems. We work on the pyloric rhythm network of the crustacean stomatogastric ganglion (STG) [2]. Typically network models of the STG treat neurons of the same functional type as a single model neuron (e.g. PD neurons), assuming the same conductance parameters for these neurons and implying their synchronous firing [3, 4]. However, simultaneous recording of PD neurons shows differences between the timings of spikes of these neurons. This may indicate functional variability of these neurons. Here we modelled separately the two PD neurons of the STG in a multi-neuron model of the pyloric network. Our neuron models comply with known correlations between conductance parameters of ionic currents. Our results reproduce the experimental finding of increasing spike time distance between spikes originating from the two model PD neurons during their synchronised burst phase. The PD neuron with the larger calcium conductance generates its spikes before the other PD neuron. Larger potassium conductance values in the follower neuron imply longer delays between spikes, see Fig. 17.Neuromodulators change the conductance parameters of neurons and maintain the ratios of these parameters [5]. Our results show that such changes may shift the individual contribution of two PD neurons to the PD-phase of the pyloric rhythm altering their functionality within this rhythm. Our work paves the way towards an accessible experimental and computational framework for the analysis of the mechanisms and impact of functional variability of neurons within the neural circuits to which they belong

Modelling human choices: MADeM and decision‑making

Research supported by FAPESP 2015/50122-0 and DFG-GRTK 1740/2. RP and AR are also part of the Research, Innovation and Dissemination Center for Neuromathematics FAPESP grant (2013/07699-0). RP is supported by a FAPESP scholarship (2013/25667-8). ACR is partially supported by a CNPq fellowship (grant 306251/2014-0)

Un modelo interactivo ubícuo aplicado al patrimonio natural y cultural del área del Montsec

En este artículo presentamos un entorno multimedia móvil y sensible al contexto, aplicado al patrimonio natural y cultural del área del Montsec. Se trata de una propuesta basada en una arquitectura ubícua, uno de los paradigmas de interacción emergentes hoy en día, y que Alan Kay denomina ¿Tercer Paradigma de computación¿. Las sierras del Montsec se sitúan en el sector más occidental del prepirineo catalán (Lleida). Se trata de un paraje con una extraordinaria riqueza geológica, histórica, paleontológica y paisajística, que cuenta con un patrimonio natural y cultural de gran importancia. Es por ello que esta zona se considera un verdadero laboratorio natural muy apreciado. La aplicación del modelo que se presenta aquí al entorno del Montsec ayudará a preservar y difundir los bienes y recursos naturales y culturales del parque, obteniendo en el área un verdadero "espacio interactivo". La disponibilidad de un terminal por parte de cualquier visitante del parque permitirá identificar al usuario y ofrecerle todo tipo de información adaptada a sus necesidades de consulta y guía interactiva personalizada según el perfil, posicionamiento geográfico e historial del usuario. Esto convierte nuestro sistema de información en un valioso material multimedia itinerante que cumple con las características de un sistema ubícuo

Nana. Ni de aquí ni de allá.Cortometraje

Treball Final de Grau en Comunicació Audiovisual. Modalitat A. Codi: CA0932. Curs acadèmic 2021-2022Este dossier muestra al público toda aquella información relacionada con la elaboración del trabajo de final de grado, el cual ha sido ejecutado por Daniela Alvear Ocampo, Paula Gayubas Balaguer, Ainoa Sánchez Herrero y Dayana Alexandra Zambrano Acosta. Este trabajo cuenta con la realización de un documento escrito y un cortometraje de 15 minutos, en el que además se encontrará todo el trabajo de preproducción, producción, postproducción e investigación sobre el tema abordado. En este caso, el proyecto se centra en la imigración latinoamericana, el racismo que muchos latinos viven al exiliarse de sus tierras natales y el sentimiento de no pertenencia, ya que muchos niños latinoamericanos no se sienten al completo del país en el que nacieron, ni del país al que migraron. Con este cortometraje se busca mostrar una realidad existente y unos sentimientos latentes en el corazón de muchas personas migrantes, que no se ven acogidas y respaldadas en el país en el que residen.This dossier shows the public all that information related to the preparation of the final degree work, which has been executed by Daniela Alvear Ocampo, Paula Gayubas Balaguer, Ainoa Sánchez Herrero and Dayana Alexandra Zambrano Acosta. This work has the realization of a written document and a short film of 15 minutes, in which you will also find all the work of pre-production, production, post-production and research on the topic addressed. In this case, the project focuses on Latin American immigration, the racism that many Latinos live when exiled from their homeland and the feeling of non-belonging, since many Latin American children do not feel completely of the country in which they were born, or the country they migrated to. This short film seeks to show an existing reality and latent feelings in the hearts of many migrants, who are not welcomed and supported in the country in which they reside