1 research outputs found
Differences Between Essential Tremor Developing Parkinson's Disease and Essential Tremor
ĂZET Amaç: Esansiel tremor (ET) en yaygâșn ekstrapiramidal hastalâșktâșr ve bazâș ET hastalarâș sonradan Parkinson Hastalâș€âș (PH) gelifltirebilirler. Ancak bugĂŒne kadar kesin bir birliktelik tanâșmlanmamâșfltâșr. Biz ET ve PH arasâșndaki iliflkiyi anlamak için, ET ile ET sonrasâș PH gelifltiren hastalar arasâșndaki farklâșlâșklarâș demografik ve klinik açâșdan arafltâșrdâșk. Yöntemler: YĂŒz kâșrk dört ET ve 336 PH hastasâș retrospektif olarak klinik kayâștla-râșndan de€erlendirildi ve yafl, cinsiyet, ET bafllama yaflâș, ailede ET öykĂŒsĂŒ, asimetrik veya simetrik tremor REM-uyku davranâșfl bozuklu€u (REM-SBD) öykĂŒsĂŒ kaydedildi. Bulgular: Otuz ĂŒĂ§ PH öncesi ET'si olan hasta önceki klinik kayâștlarâșna dayanarak ETPD hastasâș olarak de€erlendirildi. ET'den PH'e dönme sĂŒresi ortalama 12±11.4 yâșl idi (1-47). Gruplar arasâșnda cinsiyet farklâșlâș€âș yoktu. ET hastalarâșnda ETPD hastalarâș ile karflâșlafltâșrâșldâș€âșnda ortalama yafl, ET bafllama yaflâș, asimetrik tremor ve REM-SBD öykĂŒsĂŒ anlamlâș olarak daha azdâș. ET hastalarâșnda ailede ET öykĂŒsĂŒ ve bafl tremoru ETPD'den daha fazla idi. Sonuç: Bizim sonuçlarâșmâșz asimetrik tremor, geç bafllangâșçlâș ET ve REM-SBD öykĂŒsĂŒ olan ET hastalarâșnâșn sonradan PH gelifltirebilece€ine dikkati çekmifltir. ABSTRACT Objective: Essential tremor (ET) is the most prevalent extrapyramidal disorder and some ET patients may later develop Parkinson's disease (PD). However, up to date, precise association was not determined. To understand the relationship between ET and PD, we investigated differences between patients with ET and ET developing PD (ETPD) in terms of demographic and clinical characteristics. Methods: One hundred forty-four patients with ET and 336 PD patients were retrospectively assessed from their clinical charts, and their current age, gender, onset age of ET, family history of ET, asymmetrical or symmetrical tremor and history of REM-Sleep Behavior Disorders (REM-SBD) were recorded. Results: Thirty-three patients who had ET prior to PD were evaluated as ETPD patients based on previous clinical records. The mean duration from ET to PD was 12±11.4 years (range: 1-47). There was no difference in gender between the groups. The mean age, the mean age at ET onset, asymmetrical tremor and REM-SBD history were significantly lower in ET patients compared to ETPD patients. The family history of ET and head tremor was more frequent in ET patients than in ETPD. Conclusions: Our results point out that some patients with ET, having asymmetrical tremor, late onset and REM-SBD history may develop PD