A REVIEW OF NUCLEAR RECEPTOR GENE ACTIVATION THROUGH COFACTOR PROTEIN INTERACTIONS

Humans are faced with a vast number of pathological conditions. Some the most prevalent and deadly disease states include cancer, obesity, and diabetes. A large amount of scientific research and development has gone into determining the underlying cause of these pathologies. Certain aspects of the aforementioned diseases have been linked to the aberrant expression and activity of selected gene-expression-programs. Gene expression is regulated by proteins known as transcription factors. One of the largest transcription factor families is the nuclear receptor (NR) superfamily. The ability of NRs to drive gene activation is directed by specific interacting proteins called cofactors. This review will highlight new discoveries regarding the mechanistic role of NRs and their associated protein cofactors in regulating gene activation and in the progression of cancer, diabetes, and obesity

Advanced Launch System Multi-Path Redundant Avionics Architecture Analysis and Characterization

The objective of the Multi-Path Redundant Avionics Suite (MPRAS) program is the development of a set of avionic architectural modules which will be applicable to the family of launch vehicles required to support the Advanced Launch System (ALS). To enable ALS cost/performance requirements to be met, the MPRAS must support autonomy, maintenance, and testability capabilities which exceed those present in conventional launch vehicles. The multi-path redundant or fault tolerance characteristics of the MPRAS are necessary to offset a reduction in avionics reliability due to the increased complexity needed to support these new cost reduction and performance capabilities and to meet avionics reliability requirements which will provide cost-effective reductions in overall ALS recurring costs. A complex, real-time distributed computing system is needed to meet the ALS avionics system requirements. General Dynamics, Boeing Aerospace, and C.S. Draper Laboratory have proposed system architectures as candidates for the ALS MPRAS. The purpose of this document is to report the results of independent performance and reliability characterization and assessment analyses of each proposed candidate architecture and qualitative assessments of testability, maintainability, and fault tolerance mechanisms. These independent analyses were conducted as part of the MPRAS Part 2 program and were carried under NASA Langley Research Contract NAS1-17964, Task Assignment 28

Feasibility analysis of using microcircuit technology in logistics applications/radio frequency (MITLA/RF) to support equipment maintenance management

This thesis presents the background, criteria, and baseline recommendations for a Microcircuit Technology in Logistics Application/Radio Frequency (MITLA/RF) proposal to support developing maintenance management doctrine. Its main thrust is a preliminary feasibility analysis of MITLA/RF to identify key issues with regard to maintenance operations within emerging Operational Maneuver From The Sea (OMFTS) concepts. This thesis surveys current requirements, information systems initiatives, test/evaluation results, implementation issues, and technology tradeoffs. It offers alternatives to reliance on manual record keeping and frameworks for enhancing horizontal/ vertical information flows, explores several near real-time interactive decision making tools, and suggests doctrinal improvements through a fusion of procedural and high-tech approaches. This study is an outline for melding policy change with the state-of-the-art technology required to successfully support emerging Combat Service Support (CSS) operations.http://archive.org/details/feasibilitynalys1094539655Major, United States Marine CorpsCaptain, United States Marine Corps.Approved for public release; distribution is unlimited

Merger, Akusisi dan Konsolidasi dalam Perspektif Hukum Persaingan Usaha

Mergers, acquisitions and consolidation is a business strategy that is commonly used in the business world to be able to build competitive advantage company, which in time can enhance shareholder value while maximizing the prosperity of the company owners or shareholders. To achieve the above objective normative, policy-makers need a plan and steps of strategic and accurate information to avoid the risk of failure. However, the strategy of merger, acquisition and consolidation of certain potentially inhibit fair competition conditions, thus becoming one of the objects that need to be regulated in Law no. 5 Year 1999 concerning Prohibition of Monopolistic Practices and Unfair Business Competition. Market impact of mergers, acquisitions and consolidation is important for analysis because it can have significant legal consequences for businesses, so that the research method used is the juridical normative and empirical approaches. In practice of mergers, acquisitions and consolidation intersect with regulation in other sectors, especially banking and capital markets. That is, there should be equality of perception and interpretation among the institutions that issued the policy

Fly-By-Light/Power-By-Wire Requirements and Technology Workshop

The results of the Fly-By-Light/Power-By-Wire (FBL/PBW) Workshop held on March 17-19, 1992, at the NASA Langley Research Center are presented. The FBL/PBW program is a joint NASA LeRC/LaRC effort to develop the technology base for confident application of integrated FBL/PBW systems to transport aircraft. The objectives of the workshop were to ascertain the FBL/PBW program technical requirements and satisfy the requirements and needs from the industry viewpoint, provide a forum for presenting and documenting alternative technical approaches which satisfy the requirements, and assess the plan adequacy in accomplishing plan objectives, aims, and technology transfer. Areas addressed were: optical sensor systems, power-by-wire systems, FBL/PBW fault-tolerant architectures, electromagnetic environment assessment, and system integration and demonstration. The workshop consisted of an introductory meeting, a 'keynote' presentation, a series of individual panel sessions covering the above areas, with midway presentations by the panel chairpersons, followed by a final summarizing/integrating session by the individual panels, and a closing plenary session summarizing the results of the workshop

Persistence of Problematic Sexual Behaviors in Children

The purpose of this study was to identify personal and family predictors and correlates of persistence of problematic sexual behaviors (PSB) in children. Participants were the families of 49 children (ages 4–11 years) referred by Child Protective Services in 4 administrative districts of Quebec. Caregivers completed interviews and questionnaires twice at a 1-year interval. Results showed that 43% of children persisted with PSB. When age was controlled, greater exposure to sexualized behaviors in the family proved both a correlate and a predictor of PSB persistence in children 12 months later.\ud Externalizing problems and somatic complaints emerged as correlates of PSB as well. Maltreatment subtypes did not predict PSB persistence