Systematic Review Of The Published Literature On Success And Failure Rates Of Nonsurgical Endodontic Treatment

Purpose: The aim of this study was to conduct a systematic review of the literature on treatment results in non-surgical Endodontic therapy. This included researching and defining inclusion and exclusion criteria and applying these criteria to identified relevant publications. The overall goal was to analyze the available literature and synthesize these results in an effort to inform the profession on the success and failure rates in non-surgical root canal therapy. Materials and Methods: Inclusion and exclusion criteria were established in an effort to systemically review and formulate an evidence-based understanding of treatment results in non-surgical root canal therapy. A comprehensive literature search was conducted using using PubMed and the Cochrane database using the search terms root canal therapy, apical periodontitis, success, failure, and treatment outcome and was restricted to January 2009 through December 2011. Articles were reviewed and analyzed according to the inclusion/exclusion criteria. Results: A review of the abstracts for these 330 publications resulted in 51 publications articles to be examined more closely for relevance and inclusion. From this, no publication met all defined inclusion/exclusion criteria. Discussion: Defining a set of criteria for how success is defined in practice is vital to the field of Endodontics. It is important to define, establish and incorporate a standardized methodology in the way research is conducted on Endodontic treatment results. This is necessary for the application of research to the practice of evidence-based Endodontics

Hydra: software for tailored processing of H/D exchange data from MS or tandem MS analyses

<p>Abstract</p> <p>Background</p> <p>Hydrogen/deuterium exchange mass spectrometry (H/DX-MS) experiments implemented to characterize protein interaction and protein folding generate large quantities of data. Organizing, processing and visualizing data requires an automated solution, particularly when accommodating new tandem mass spectrometry modes for H/DX measurement. We sought to develop software that offers flexibility in defining workflows so as to support exploratory treatments of H/DX-MS data, with a particular focus on the analysis of very large protein systems and the mining of tandem mass spectrometry data.</p> <p>Results</p> <p>We present a software package ("Hydra") that supports both traditional and exploratory treatments of H/DX-MS data. Hydra's software architecture tolerates flexible data analysis procedures by allowing the addition of new algorithms without significant change to the underlying code base. Convenient user interfaces ease the organization of raw data files and input of peptide data. After executing a user-defined workflow, extracted deuterium incorporation values can be visualized in tabular and graphical formats. Hydra also automates the extraction and visualization of deuterium distribution values. Manual validation and assessment of results is aided by an interface that aligns extracted ion chromatograms and mass spectra, while providing a means of rapidly reprocessing the data following manual adjustment. A unique feature of Hydra is the automated processing of tandem mass spectrometry data, demonstrated on a large test data set in which 40,000 deuterium incorporation values were extracted from replicate analysis of approximately 1000 fragment ions in one hour using a typical PC.</p> <p>Conclusion</p> <p>The customizable workflows and user-friendly interfaces of Hydra removes a significant bottleneck in processing and visualizing H/DX-MS data and helps the researcher spend more time executing new experiments and interpreting results. This increased efficiency will encourage the analysis of larger protein systems. The ability to accommodate the tandem MS dimension supports alternative data collection and analysis strategies, as well as higher resolution localization of deuteration where permitted by the fragmentation mechanism.</p

Global Cicada Sound Collection I: Recordings from South Africa and Malawi by BW Price and MH Villet and harvesting of BioAcoustica data by GBIF

Sound collections for singing insects provide important repositories that underpin existing research (eg Price et al. 2007 at http://bio. acousti. ca/node/11801; Price et al. 2010) and make bioacoustic collections available for future work, including insect communication (Ordish 1992), systematics (eg David et al. 2003), and automated identification (Bennett et al. 2015). The BioAcoustica platform (Baker et al. 2015) is both a repository and analysis platform for bioacoustic collections: allowing collections to be available in perpetuity, and also facilitating complex analyses using the BioVeL cloud infrastructure (Vicario et al. 2011). The Global Cicada Sound Collection is a project to make recordings of the world's cicadas (Hemiptera: Cicadidae) available using open licences to maximise their potential for study and reuse. This first component of the Global Cicada Sound Collection comprises recordings made between 2006 and 2008 of Cicadidae in South Africa and Malawi