55 research outputs found

    India and the Crisis in Kashmir

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    With the end of the Cold War, regional security problems have become paradigmatic. Whereas they were once seen primarily as functions of-or in some cases even epiphenomenal to-superpower rivalry, they are now central. International security is largely regional security in the absence of a global strategic conflict. As a result, attention has shifted from consideration of the global strategic balance to local conflict. Broadly, these local conflicts are a function of two factors: regional distributions of power but also animosities rooted in ethnic, religious, territorial, and irredentist contestation. The problem for policy is that the latter factors are more intractable than the former; distributions of power are more amenable to management than are animosities based on, or evocative of seemingly old quarrels and fears. This article focuses on one of the most costly and dangerous of these animosities, namely, the Indian and Pakistani contest over the divided state of Kashmir

    Therapeutic potential of new B cell-targeted agents in the treatment of elderly and unfit patients with chronic lymphocytic leukemia

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    Chronic lymphocytic leukemia (CLL), the most common adult leukemia in the Western world, is primarily a disease of the elderly, with most patients ≥65 years of age and having at least one major comorbidity. Aggressive chemoimmunotherapy regimens recommended to achieve remission and improve survival in young, fit patients are often poorly tolerated in elderly and/or less physiologically fit (“unfit”) patients, necessitating alternative treatment options. Although patient age, fitness, and comorbidities are key considerations in the selection of a treatment regimen, historically, clinical trials have been limited to young, fit patients by virtue of the ethical concerns associated with potential end organ toxic effects that could worsen comorbidities. However, the availability of new therapies promises a shift to a research paradigm that encompasses the identification of optimal treatments for elderly and unfit patients. Anti-CD20 monoclonal antibody therapy, which overall has improved response rates and survival in patients with CLL, has only recently been evaluated elderly and unfit patients. B cell-targeted agents such as the Bruton’s tyrosine kinase inhibitor ibrutinib and the phosphatidylinositol 3-kinase inhibitor idelalisib are the first of a new generation of oral agents for CLL. Available clinical data suggest that these therapies have the potential to address the unmet need in elderly and unfit patients with CLL and result in clinical remission, and not merely symptom palliation and improved quality of life, which, by themselves, are also a reasonable goal

    Indian Higher Education: Privatization, Dignified Spaces, and Curricular Reform

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    The Future of Indian Universities167-19

    An inquiry into colonial disengagement : the cabinet delegation to India, March to June, 1946

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    This thesis is about colonial disengagement, a term signifying the process of decolonisation from the decision to end colonial rule to the final withdrawal of imperial officials and armed personnel. Specifically, this thesis is about British colonial disengagement as revealed in a vital case—India during the period March 1946 to August 1947. The focus is on the role of the British Government in that process, which, in the Indian case, involved the transfer of political authority—that is of ultimate responsibility for government— from imperial to nationalist hands. This occurred in two phases: the first, during the Cabinet Delegation's mission to India from March to June 1946; and the second, during Mountbatten's mission from March to August 1947. In analysing the role of the British Government, the inquiry will deal with the former phase, of which a detailed first-hand account is available in "The Transfer of Power" archival documents recently released by the British Government pertaining to the period 1942-1947. The documents are used extensively in the analysis. The attempt is made to explain the role of the British Government in terms of the interaction and impact of five factors: (i) British interests; (ii) British obligations; (iii) the desire for a peaceful and orderly transfer of authority; (iv) the momentum of constitutional change; and (v) declining British power in the face of the increasingly powerful and polarised nationalist movement. On the basis of the evidence collected primarily, from the documents, but also from important secondary sources, it is argued that while each of these factors had an impact on how Britain disengaged, three factors in particular were most significant: British strategic interests, the desire for a peaceful and orderly transfer of authority and the lack of British power in relation to the nationalist movement. These three factors, it is further argued, interacted to cause the government to pursue a disengagement plan that would elicit the agreement of the two major nationalist parties—the Indian National Congress and the Muslim League—and that this pursuit, in turn, seriously limited its room for manoeuvre in the process of transferring authority. It is shown, finally, that the lack of room for manoeuvre was partly inherent in the Indian political situation and partly in British objectives, and that the Congress and the League were equally constrained by similar factors. Thus, in the end, it is concluded that to the extent that the Indian case is paradigmatic of British disengagements generally a more pessimistic view of what accommodations and political arrangements the departing imperial administrations and nationalist movements can or cannot make during the process of transferring authority may be necessary.Arts, Faculty ofPolitical Science, Department ofGraduat

    Introduction: Explaining Cooperation and Rivalry in China-India Relations

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    Journal of Contemporary China32141353-36

    Between informality and formality

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    Great Power Multilateralism and the Prevention of War195-20
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