Flukicidal effects of abietane diterpenoid derived analogues against the food borne pathogen Fasciola hepatica.

Control of liver fluke infections remains a significant challenge in the livestock sector due to widespread distribution of drug resistant parasite populations. In particular, increasing prevalence and economic losses due to infection with Fasciola hepatica is a direct result of drug resistance to the gold standard flukicide, triclabendazole. Sustainable control of this significant zoonotic pathogen, therefore, urgently requires the identification of new anthelmintics. Plants represent a source of molecules with potential flukicidal effects and, amongst their secondary metabolites, the diterpenoid abietic acids can be isolated in large quantities. In this study, nineteen (19) chemically modified abietic acid analogues (MC_X) were first evaluated for their anthelmintic activities against F. hepatica newly excysted juveniles (NEJs, from the laboratory-derived Italian strain); from this, 6 analogues were secondly evaluated for their anthelmintic activities against adult wild strain flukes. One analogue, MC010, was progressed further against 8-week immature- and 12-week mature Italian strain flukes. Here, MC010 demonstrated moderate activity against both of these intra-mammalian fluke stages (with an adult fluke EC50 = 12.97 µM at 72 h post culture). Overt mammalian cell toxicity of MC010 was inferred from the Madin-Darby bovine kidney (MDBK) cell line (CC50 = 17.52 µM at 24 h post culture) and demonstrated that medicinal chemistry improvements are necessary before abietic acid analogues could be considered as potential anthelmintics against liver fluke pathogen

Exploiting a fast neutron mutant genetic resource in Pisum sativum (pea) for functional genomics

A fast neutron mutagenised population was generated in Pisum sativum L. (pea) to enable the identification and isolation of genes underlying traits and processes. Studies of a number of phenotypic traits have clearly demonstrated the utility of the resource by associating gene deletions with phenotype followed by functional tests exploiting additional mutant sources, from both induced and natural variant germplasm. For forward genetic screens next generation sequencing methodologies provide an opportunity for identifying genes associated with deletions rapidly and systematically. The application of rapid reverse genetic screens of the fast neutron mutant pea population supports conclusions on the frequency of deletions based on phenotype alone. These studies further suggest that large deletions affecting one or more loci can be non-deleterious to the pea genome, yielding mutants that could not be obtained by other means. Deletion mutants affecting genes associated with seed metabolism and storage are providing unique opportunities to identify the products of complex and related gene families, and to study the downstream consequences of such deletion

African linguistics across the disciplines: Selected papers from the 48th Annual Conference on African Linguistics

Since the hiring of its first Africanist linguist Carleton Hodge in 1964, Indiana University’s Department of Linguistics has had a strong and continuing presence in the study of African languages and linguistics through the work of its faculty and of its graduates on the faculties of many other universities. Research on African linguistics at IU has covered some of the major language groups spoken on the African continent. Carleton Hodge’s work on Ancient Egyptian and Hausa, Paul Newman’s work on Hausa and Chadic languages, and Roxanna Ma Newman’s work on Hausa language structure and pedagogy have been some of the most important studies on Afro-Asiatic linguistics. With respect to Niger-Congo languages, the work of Charles Bird on Bambara and the Mande languages, Robert Botne’s work on Bantu structure (especially tense and aspect), Samuel Obeng and Colin Painter’s work on Ghanaian Languages (phonetics, phonology, and pragmatics), Robert Port’s studies on Swahili, and Erhard Voeltz's studies on Bantu linguistics are considered some of the most influential studies in the sub-field. On Nilo Saharan languages, the work of Tim Shopen on Songhay stands out. IU Linguistics has also forwarded theoretical work on African languages, such as John Goldsmith’s seminal research on tone in African languages. The African linguistics faculty at IU have either founded or edited important journals in African Studies, African languages, and African linguistics, including Africa Today, Studies in African Linguistics, and Journal of African Languages and Linguistics. In 1972, the Indiana University Department of Linguistics hosted the Third Annual Conference of African Linguistics. Proceedings of that conference were published by Indiana University Publications (African Series, vol. 7). In 1986, IU hosted the Seventeenth Annual Conference of African Linguistics with Paul Newman and Robert Botne editing the proceedings in a volume entitled Current Approaches to African Linguistics, vol. 5. In 2016, Indiana University hosted the 48th Annual Conference on African Linguistics with the theme African Linguistics Across the Disciplines. Proceedings of that meeting are published in this volume. The papers presented in this volume reflect the diversity of opportunities for language study in Africa. This collection of descriptive and theoretical work is the fruit of data gathering both in-country and abroad by researchers of languages spoken across the continent, from Sereer-sin in the west to Somali in the northeast to Ikalanga in the south. The range of topics in this volume is also broad, representative of the varied field work in country and abroad that inspires research in African linguistics. This collection of papers spans the disciplines of phonology (both segmental and suprasegmental), morphology (both morphophonological and morphosyntactic), syntax, semantics, and language policy. The data and analyses presented in this volume offer a cross-disciplinary view of linguistic topics from the many under-resourced languages of Africa

African linguistics across the disciplines: Selected papers from the 48th Annual Conference on African Linguistics

Since the hiring of its first Africanist linguist Carleton Hodge in 1964, Indiana University’s Department of Linguistics has had a strong and continuing presence in the study of African languages and linguistics through the work of its faculty and of its graduates on the faculties of many other universities. Research on African linguistics at IU has covered some of the major language groups spoken on the African continent. Carleton Hodge’s work on Ancient Egyptian and Hausa, Paul Newman’s work on Hausa and Chadic languages, and Roxanna Ma Newman’s work on Hausa language structure and pedagogy have been some of the most important studies on Afro-Asiatic linguistics. With respect to Niger-Congo languages, the work of Charles Bird on Bambara and the Mande languages, Robert Botne’s work on Bantu structure (especially tense and aspect), Samuel Obeng and Colin Painter’s work on Ghanaian Languages (phonetics, phonology, and pragmatics), Robert Port’s studies on Swahili, and Erhard Voeltz's studies on Bantu linguistics are considered some of the most influential studies in the sub-field. On Nilo Saharan languages, the work of Tim Shopen on Songhay stands out. IU Linguistics has also forwarded theoretical work on African languages, such as John Goldsmith’s seminal research on tone in African languages. The African linguistics faculty at IU have either founded or edited important journals in African Studies, African languages, and African linguistics, including Africa Today, Studies in African Linguistics, and Journal of African Languages and Linguistics. In 1972, the Indiana University Department of Linguistics hosted the Third Annual Conference of African Linguistics. Proceedings of that conference were published by Indiana University Publications (African Series, vol. 7). In 1986, IU hosted the Seventeenth Annual Conference of African Linguistics with Paul Newman and Robert Botne editing the proceedings in a volume entitled Current Approaches to African Linguistics, vol. 5. In 2016, Indiana University hosted the 48th Annual Conference on African Linguistics with the theme African Linguistics Across the Disciplines. Proceedings of that meeting are published in this volume. The papers presented in this volume reflect the diversity of opportunities for language study in Africa. This collection of descriptive and theoretical work is the fruit of data gathering both in-country and abroad by researchers of languages spoken across the continent, from Sereer-sin in the west to Somali in the northeast to Ikalanga in the south. The range of topics in this volume is also broad, representative of the varied field work in country and abroad that inspires research in African linguistics. This collection of papers spans the disciplines of phonology (both segmental and suprasegmental), morphology (both morphophonological and morphosyntactic), syntax, semantics, and language policy. The data and analyses presented in this volume offer a cross-disciplinary view of linguistic topics from the many under-resourced languages of Africa

African linguistics across the disciplines: Selected papers from the 48th Annual Conference on African Linguistics

Since the hiring of its first Africanist linguist Carleton Hodge in 1964, Indiana University’s Department of Linguistics has had a strong and continuing presence in the study of African languages and linguistics through the work of its faculty and of its graduates on the faculties of many other universities. Research on African linguistics at IU has covered some of the major language groups spoken on the African continent. Carleton Hodge’s work on Ancient Egyptian and Hausa, Paul Newman’s work on Hausa and Chadic languages, and Roxanna Ma Newman’s work on Hausa language structure and pedagogy have been some of the most important studies on Afro-Asiatic linguistics. With respect to Niger-Congo languages, the work of Charles Bird on Bambara and the Mande languages, Robert Botne’s work on Bantu structure (especially tense and aspect), Samuel Obeng and Colin Painter’s work on Ghanaian Languages (phonetics, phonology, and pragmatics), Robert Port’s studies on Swahili, and Erhard Voeltz's studies on Bantu linguistics are considered some of the most influential studies in the sub-field. On Nilo Saharan languages, the work of Tim Shopen on Songhay stands out. IU Linguistics has also forwarded theoretical work on African languages, such as John Goldsmith’s seminal research on tone in African languages. The African linguistics faculty at IU have either founded or edited important journals in African Studies, African languages, and African linguistics, including Africa Today, Studies in African Linguistics, and Journal of African Languages and Linguistics. In 1972, the Indiana University Department of Linguistics hosted the Third Annual Conference of African Linguistics. Proceedings of that conference were published by Indiana University Publications (African Series, vol. 7). In 1986, IU hosted the Seventeenth Annual Conference of African Linguistics with Paul Newman and Robert Botne editing the proceedings in a volume entitled Current Approaches to African Linguistics, vol. 5. In 2016, Indiana University hosted the 48th Annual Conference on African Linguistics with the theme African Linguistics Across the Disciplines. Proceedings of that meeting are published in this volume. The papers presented in this volume reflect the diversity of opportunities for language study in Africa. This collection of descriptive and theoretical work is the fruit of data gathering both in-country and abroad by researchers of languages spoken across the continent, from Sereer-sin in the west to Somali in the northeast to Ikalanga in the south. The range of topics in this volume is also broad, representative of the varied field work in country and abroad that inspires research in African linguistics. This collection of papers spans the disciplines of phonology (both segmental and suprasegmental), morphology (both morphophonological and morphosyntactic), syntax, semantics, and language policy. The data and analyses presented in this volume offer a cross-disciplinary view of linguistic topics from the many under-resourced languages of Africa

African linguistics across the disciplines: Selected papers from the 48th Annual Conference on African Linguistics

Since the hiring of its first Africanist linguist Carleton Hodge in 1964, Indiana University’s Department of Linguistics has had a strong and continuing presence in the study of African languages and linguistics through the work of its faculty and of its graduates on the faculties of many other universities. Research on African linguistics at IU has covered some of the major language groups spoken on the African continent. Carleton Hodge’s work on Ancient Egyptian and Hausa, Paul Newman’s work on Hausa and Chadic languages, and Roxanna Ma Newman’s work on Hausa language structure and pedagogy have been some of the most important studies on Afro-Asiatic linguistics. With respect to Niger-Congo languages, the work of Charles Bird on Bambara and the Mande languages, Robert Botne’s work on Bantu structure (especially tense and aspect), Samuel Obeng and Colin Painter’s work on Ghanaian Languages (phonetics, phonology, and pragmatics), Robert Port’s studies on Swahili, and Erhard Voeltz's studies on Bantu linguistics are considered some of the most influential studies in the sub-field. On Nilo Saharan languages, the work of Tim Shopen on Songhay stands out. IU Linguistics has also forwarded theoretical work on African languages, such as John Goldsmith’s seminal research on tone in African languages. The African linguistics faculty at IU have either founded or edited important journals in African Studies, African languages, and African linguistics, including Africa Today, Studies in African Linguistics, and Journal of African Languages and Linguistics. In 1972, the Indiana University Department of Linguistics hosted the Third Annual Conference of African Linguistics. Proceedings of that conference were published by Indiana University Publications (African Series, vol. 7). In 1986, IU hosted the Seventeenth Annual Conference of African Linguistics with Paul Newman and Robert Botne editing the proceedings in a volume entitled Current Approaches to African Linguistics, vol. 5. In 2016, Indiana University hosted the 48th Annual Conference on African Linguistics with the theme African Linguistics Across the Disciplines. Proceedings of that meeting are published in this volume. The papers presented in this volume reflect the diversity of opportunities for language study in Africa. This collection of descriptive and theoretical work is the fruit of data gathering both in-country and abroad by researchers of languages spoken across the continent, from Sereer-sin in the west to Somali in the northeast to Ikalanga in the south. The range of topics in this volume is also broad, representative of the varied field work in country and abroad that inspires research in African linguistics. This collection of papers spans the disciplines of phonology (both segmental and suprasegmental), morphology (both morphophonological and morphosyntactic), syntax, semantics, and language policy. The data and analyses presented in this volume offer a cross-disciplinary view of linguistic topics from the many under-resourced languages of Africa

African linguistics across the disciplines: Selected papers from the 48th Annual Conference on African Linguistics

Since the hiring of its first Africanist linguist Carleton Hodge in 1964, Indiana University’s Department of Linguistics has had a strong and continuing presence in the study of African languages and linguistics through the work of its faculty and of its graduates on the faculties of many other universities. Research on African linguistics at IU has covered some of the major language groups spoken on the African continent. Carleton Hodge’s work on Ancient Egyptian and Hausa, Paul Newman’s work on Hausa and Chadic languages, and Roxanna Ma Newman’s work on Hausa language structure and pedagogy have been some of the most important studies on Afro-Asiatic linguistics. With respect to Niger-Congo languages, the work of Charles Bird on Bambara and the Mande languages, Robert Botne’s work on Bantu structure (especially tense and aspect), Samuel Obeng and Colin Painter’s work on Ghanaian Languages (phonetics, phonology, and pragmatics), Robert Port’s studies on Swahili, and Erhard Voeltz's studies on Bantu linguistics are considered some of the most influential studies in the sub-field. On Nilo Saharan languages, the work of Tim Shopen on Songhay stands out. IU Linguistics has also forwarded theoretical work on African languages, such as John Goldsmith’s seminal research on tone in African languages. The African linguistics faculty at IU have either founded or edited important journals in African Studies, African languages, and African linguistics, including Africa Today, Studies in African Linguistics, and Journal of African Languages and Linguistics. In 1972, the Indiana University Department of Linguistics hosted the Third Annual Conference of African Linguistics. Proceedings of that conference were published by Indiana University Publications (African Series, vol. 7). In 1986, IU hosted the Seventeenth Annual Conference of African Linguistics with Paul Newman and Robert Botne editing the proceedings in a volume entitled Current Approaches to African Linguistics, vol. 5. In 2016, Indiana University hosted the 48th Annual Conference on African Linguistics with the theme African Linguistics Across the Disciplines. Proceedings of that meeting are published in this volume. The papers presented in this volume reflect the diversity of opportunities for language study in Africa. This collection of descriptive and theoretical work is the fruit of data gathering both in-country and abroad by researchers of languages spoken across the continent, from Sereer-sin in the west to Somali in the northeast to Ikalanga in the south. The range of topics in this volume is also broad, representative of the varied field work in country and abroad that inspires research in African linguistics. This collection of papers spans the disciplines of phonology (both segmental and suprasegmental), morphology (both morphophonological and morphosyntactic), syntax, semantics, and language policy. The data and analyses presented in this volume offer a cross-disciplinary view of linguistic topics from the many under-resourced languages of Africa

African linguistics across the disciplines: Selected papers from the 48th Annual Conference on African Linguistics

Since the hiring of its first Africanist linguist Carleton Hodge in 1964, Indiana University’s Department of Linguistics has had a strong and continuing presence in the study of African languages and linguistics through the work of its faculty and of its graduates on the faculties of many other universities. Research on African linguistics at IU has covered some of the major language groups spoken on the African continent. Carleton Hodge’s work on Ancient Egyptian and Hausa, Paul Newman’s work on Hausa and Chadic languages, and Roxanna Ma Newman’s work on Hausa language structure and pedagogy have been some of the most important studies on Afro-Asiatic linguistics. With respect to Niger-Congo languages, the work of Charles Bird on Bambara and the Mande languages, Robert Botne’s work on Bantu structure (especially tense and aspect), Samuel Obeng and Colin Painter’s work on Ghanaian Languages (phonetics, phonology, and pragmatics), Robert Port’s studies on Swahili, and Erhard Voeltz's studies on Bantu linguistics are considered some of the most influential studies in the sub-field. On Nilo Saharan languages, the work of Tim Shopen on Songhay stands out. IU Linguistics has also forwarded theoretical work on African languages, such as John Goldsmith’s seminal research on tone in African languages. The African linguistics faculty at IU have either founded or edited important journals in African Studies, African languages, and African linguistics, including Africa Today, Studies in African Linguistics, and Journal of African Languages and Linguistics. In 1972, the Indiana University Department of Linguistics hosted the Third Annual Conference of African Linguistics. Proceedings of that conference were published by Indiana University Publications (African Series, vol. 7). In 1986, IU hosted the Seventeenth Annual Conference of African Linguistics with Paul Newman and Robert Botne editing the proceedings in a volume entitled Current Approaches to African Linguistics, vol. 5. In 2016, Indiana University hosted the 48th Annual Conference on African Linguistics with the theme African Linguistics Across the Disciplines. Proceedings of that meeting are published in this volume. The papers presented in this volume reflect the diversity of opportunities for language study in Africa. This collection of descriptive and theoretical work is the fruit of data gathering both in-country and abroad by researchers of languages spoken across the continent, from Sereer-sin in the west to Somali in the northeast to Ikalanga in the south. The range of topics in this volume is also broad, representative of the varied field work in country and abroad that inspires research in African linguistics. This collection of papers spans the disciplines of phonology (both segmental and suprasegmental), morphology (both morphophonological and morphosyntactic), syntax, semantics, and language policy. The data and analyses presented in this volume offer a cross-disciplinary view of linguistic topics from the many under-resourced languages of Africa

African linguistics across the disciplines: Selected papers from the 48th Annual Conference on African Linguistics

Since the hiring of its first Africanist linguist Carleton Hodge in 1964, Indiana University’s Department of Linguistics has had a strong and continuing presence in the study of African languages and linguistics through the work of its faculty and of its graduates on the faculties of many other universities. Research on African linguistics at IU has covered some of the major language groups spoken on the African continent. Carleton Hodge’s work on Ancient Egyptian and Hausa, Paul Newman’s work on Hausa and Chadic languages, and Roxanna Ma Newman’s work on Hausa language structure and pedagogy have been some of the most important studies on Afro-Asiatic linguistics. With respect to Niger-Congo languages, the work of Charles Bird on Bambara and the Mande languages, Robert Botne’s work on Bantu structure (especially tense and aspect), Samuel Obeng and Colin Painter’s work on Ghanaian Languages (phonetics, phonology, and pragmatics), Robert Port’s studies on Swahili, and Erhard Voeltz's studies on Bantu linguistics are considered some of the most influential studies in the sub-field. On Nilo Saharan languages, the work of Tim Shopen on Songhay stands out. IU Linguistics has also forwarded theoretical work on African languages, such as John Goldsmith’s seminal research on tone in African languages. The African linguistics faculty at IU have either founded or edited important journals in African Studies, African languages, and African linguistics, including Africa Today, Studies in African Linguistics, and Journal of African Languages and Linguistics. In 1972, the Indiana University Department of Linguistics hosted the Third Annual Conference of African Linguistics. Proceedings of that conference were published by Indiana University Publications (African Series, vol. 7). In 1986, IU hosted the Seventeenth Annual Conference of African Linguistics with Paul Newman and Robert Botne editing the proceedings in a volume entitled Current Approaches to African Linguistics, vol. 5. In 2016, Indiana University hosted the 48th Annual Conference on African Linguistics with the theme African Linguistics Across the Disciplines. Proceedings of that meeting are published in this volume. The papers presented in this volume reflect the diversity of opportunities for language study in Africa. This collection of descriptive and theoretical work is the fruit of data gathering both in-country and abroad by researchers of languages spoken across the continent, from Sereer-sin in the west to Somali in the northeast to Ikalanga in the south. The range of topics in this volume is also broad, representative of the varied field work in country and abroad that inspires research in African linguistics. This collection of papers spans the disciplines of phonology (both segmental and suprasegmental), morphology (both morphophonological and morphosyntactic), syntax, semantics, and language policy. The data and analyses presented in this volume offer a cross-disciplinary view of linguistic topics from the many under-resourced languages of Africa

African linguistics across the disciplines: Selected papers from the 48th Annual Conference on African Linguistics

Since the hiring of its first Africanist linguist Carleton Hodge in 1964, Indiana University’s Department of Linguistics has had a strong and continuing presence in the study of African languages and linguistics through the work of its faculty and of its graduates on the faculties of many other universities. Research on African linguistics at IU has covered some of the major language groups spoken on the African continent. Carleton Hodge’s work on Ancient Egyptian and Hausa, Paul Newman’s work on Hausa and Chadic languages, and Roxanna Ma Newman’s work on Hausa language structure and pedagogy have been some of the most important studies on Afro-Asiatic linguistics. With respect to Niger-Congo languages, the work of Charles Bird on Bambara and the Mande languages, Robert Botne’s work on Bantu structure (especially tense and aspect), Samuel Obeng and Colin Painter’s work on Ghanaian Languages (phonetics, phonology, and pragmatics), Robert Port’s studies on Swahili, and Erhard Voeltz's studies on Bantu linguistics are considered some of the most influential studies in the sub-field. On Nilo Saharan languages, the work of Tim Shopen on Songhay stands out. IU Linguistics has also forwarded theoretical work on African languages, such as John Goldsmith’s seminal research on tone in African languages. The African linguistics faculty at IU have either founded or edited important journals in African Studies, African languages, and African linguistics, including Africa Today, Studies in African Linguistics, and Journal of African Languages and Linguistics. In 1972, the Indiana University Department of Linguistics hosted the Third Annual Conference of African Linguistics. Proceedings of that conference were published by Indiana University Publications (African Series, vol. 7). In 1986, IU hosted the Seventeenth Annual Conference of African Linguistics with Paul Newman and Robert Botne editing the proceedings in a volume entitled Current Approaches to African Linguistics, vol. 5. In 2016, Indiana University hosted the 48th Annual Conference on African Linguistics with the theme African Linguistics Across the Disciplines. Proceedings of that meeting are published in this volume. The papers presented in this volume reflect the diversity of opportunities for language study in Africa. This collection of descriptive and theoretical work is the fruit of data gathering both in-country and abroad by researchers of languages spoken across the continent, from Sereer-sin in the west to Somali in the northeast to Ikalanga in the south. The range of topics in this volume is also broad, representative of the varied field work in country and abroad that inspires research in African linguistics. This collection of papers spans the disciplines of phonology (both segmental and suprasegmental), morphology (both morphophonological and morphosyntactic), syntax, semantics, and language policy. The data and analyses presented in this volume offer a cross-disciplinary view of linguistic topics from the many under-resourced languages of Africa